Progress and prospects in mapping recent selection in the genome
One of the central goals of evolutionary biology is to understand the genetic basis of adaptive evolution. The availability of nearly complete genome sequences from a variety of organisms has facilitated the collection of data on naturally occurring genetic variation on the scale of hundreds of loci...
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| Veröffentlicht in: | Heredity 2007-06, Vol.98 (6), p.340-348 |
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| creator | Thornton, K R Jensen, J D Becquet, C Andolfatto, P |
| description | One of the central goals of evolutionary biology is to understand the genetic basis of adaptive evolution. The availability of nearly complete genome sequences from a variety of organisms has facilitated the collection of data on naturally occurring genetic variation on the scale of hundreds of loci to whole genomes. Such data have changed the focus of molecular population genetics from making inferences about adaptive evolution at single loci to identifying which loci, out of hundreds to thousands, have been recent targets of natural selection. A major challenge in this effort is distinguishing the effects of selection from those of the demographic history of populations. Here we review some current progress and remaining challenges in the field. |
| doi_str_mv | 10.1038/sj.hdy.6800967 |
| format | Article |
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| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biomedical and Life Sciences Biomedicine Chromosome Mapping - methods Chromosome Mapping - trends Cytogenetics Ecology Evolutionary Biology Gene Frequency Gene loci Genetic diversity Genetic Variation Genetics Genome, Human Genomics Heredity Human Genetics Humans Models, Genetic Plant Genetics and Genomics Population genetics Selection, Genetic short-review Time Factors |
| title | Progress and prospects in mapping recent selection in the genome |
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