Bilateral intra‐oral, infra‐orbital nerve block for postoperative analgesia following cleft lip repair in paediatric patients: comparison of bupivacaine vs bupivacaine–pethidine combination
Summary This prospective, randomised, double blind study compared the efficacy of pethidine as an adjuvant to bupivacaine with the efficacy of bupivacaine alone for infra‐orbital nerve block in alleviating postoperative pain in children undergoing cleft lip repair. Forty paediatric patients aged bet...
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| Veröffentlicht in: | Anaesthesia 2007-06, Vol.62 (6), p.581-585 |
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| creator | Jonnavithula, N. Durga, P. Kulkarni, D. K. Ramachandran, G. |
| description | Summary
This prospective, randomised, double blind study compared the efficacy of pethidine as an adjuvant to bupivacaine with the efficacy of bupivacaine alone for infra‐orbital nerve block in alleviating postoperative pain in children undergoing cleft lip repair. Forty paediatric patients aged between 5 and 60 months undergoing cleft lip repair were randomly allocated to two groups of 20. After tracheal intubation, group B received bilateral intra‐oral, infra‐orbital nerve block with 1 ml of 0.25% bupivacaine on each side and group P received 1 ml of 0.25% bupivacaine along with 0.25 mg.kg−1 body weight pethidine. Sedation after recovery from anaesthesia was assessed using the University of Michigan Sedation Scale (UMSS) and pain was assessed postoperatively up to 36 h using the FLACC scale (Face, Legs, Activity, Cry, Consolability). The median (IQR) duration of analgesia from the time of administration of block in group B was 18 h (14.2–20) compared to 29.1 h (24–36) in group P (p = 0.001). Addition of pethidine as an adjunct to local anaesthetic significantly prolonged the duration of postoperative analgesia without any adverse effects. |
| doi_str_mv | 10.1111/j.1365-2044.2007.05028.x |
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This prospective, randomised, double blind study compared the efficacy of pethidine as an adjuvant to bupivacaine with the efficacy of bupivacaine alone for infra‐orbital nerve block in alleviating postoperative pain in children undergoing cleft lip repair. Forty paediatric patients aged between 5 and 60 months undergoing cleft lip repair were randomly allocated to two groups of 20. After tracheal intubation, group B received bilateral intra‐oral, infra‐orbital nerve block with 1 ml of 0.25% bupivacaine on each side and group P received 1 ml of 0.25% bupivacaine along with 0.25 mg.kg−1 body weight pethidine. Sedation after recovery from anaesthesia was assessed using the University of Michigan Sedation Scale (UMSS) and pain was assessed postoperatively up to 36 h using the FLACC scale (Face, Legs, Activity, Cry, Consolability). The median (IQR) duration of analgesia from the time of administration of block in group B was 18 h (14.2–20) compared to 29.1 h (24–36) in group P (p = 0.001). Addition of pethidine as an adjunct to local anaesthetic significantly prolonged the duration of postoperative analgesia without any adverse effects.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.2007.05028.x</identifier><identifier>PMID: 17506736</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject><![CDATA[Analgesics ; Analgesics, Opioid - administration & dosage ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthesiology ; Anesthetics, Combined - administration & dosage ; Anesthetics, Local - administration & dosage ; Biological and medical sciences ; Birth defects ; Bupivacaine - administration & dosage ; Child, Preschool ; Cleft Lip - surgery ; Clinical trials ; Comparative studies ; Double-Blind Method ; Female ; Humans ; Infant ; Male ; Medical sciences ; Meperidine - administration & dosage ; Nerve Block - methods ; Nervous system ; Pain ; Pain Measurement - methods ; Pain, Postoperative - prevention & control ; Pediatrics ; Prospective Studies ; Side effects]]></subject><ispartof>Anaesthesia, 2007-06, Vol.62 (6), p.581-585</ispartof><rights>2007 INIST-CNRS</rights><rights>2007 The Authors Journal compilation 2007 The Association of Anaesthetists of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5008-830d0ca8cc7b43f74d69863fa106828d5e49373f7c11d7d584a56fcab5fafa223</citedby><cites>FETCH-LOGICAL-c5008-830d0ca8cc7b43f74d69863fa106828d5e49373f7c11d7d584a56fcab5fafa223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.2007.05028.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.2007.05028.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18753737$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17506736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jonnavithula, N.</creatorcontrib><creatorcontrib>Durga, P.</creatorcontrib><creatorcontrib>Kulkarni, D. K.</creatorcontrib><creatorcontrib>Ramachandran, G.</creatorcontrib><title>Bilateral intra‐oral, infra‐orbital nerve block for postoperative analgesia following cleft lip repair in paediatric patients: comparison of bupivacaine vs bupivacaine–pethidine combination</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
This prospective, randomised, double blind study compared the efficacy of pethidine as an adjuvant to bupivacaine with the efficacy of bupivacaine alone for infra‐orbital nerve block in alleviating postoperative pain in children undergoing cleft lip repair. Forty paediatric patients aged between 5 and 60 months undergoing cleft lip repair were randomly allocated to two groups of 20. After tracheal intubation, group B received bilateral intra‐oral, infra‐orbital nerve block with 1 ml of 0.25% bupivacaine on each side and group P received 1 ml of 0.25% bupivacaine along with 0.25 mg.kg−1 body weight pethidine. Sedation after recovery from anaesthesia was assessed using the University of Michigan Sedation Scale (UMSS) and pain was assessed postoperatively up to 36 h using the FLACC scale (Face, Legs, Activity, Cry, Consolability). The median (IQR) duration of analgesia from the time of administration of block in group B was 18 h (14.2–20) compared to 29.1 h (24–36) in group P (p = 0.001). Addition of pethidine as an adjunct to local anaesthetic significantly prolonged the duration of postoperative analgesia without any adverse effects.</description><subject>Analgesics</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthesiology</subject><subject>Anesthetics, Combined - administration & dosage</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Birth defects</subject><subject>Bupivacaine - administration & dosage</subject><subject>Child, Preschool</subject><subject>Cleft Lip - surgery</subject><subject>Clinical trials</subject><subject>Comparative studies</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meperidine - administration & dosage</subject><subject>Nerve Block - methods</subject><subject>Nervous system</subject><subject>Pain</subject><subject>Pain Measurement - methods</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Side effects</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2OFCEUhStG47Sjr2CIia7sEoqioF2YtJPxJ5noRtfkFgUjLQ0l0D0zu3kEEx_JN5knkbIrjnElG-7lfOcGOFWFCK5JWS82NaEdWza4besGY15jhhtRX96pFn-Eu9UCY0yXTYtXR9WDlDYYk0YQcb86IpzhjtNuUf18bR1kHcEh63OEm-vvoTTPS2fmrre5qF7HvUa9C-orMiGiMaQcxmLMtpyDB3euk4WiORcurD9HymmTkbMjinoEG8tINIIeLORoVSmz1T6nl0iF7QjRpuBRMKjfjXYPCqzXaJ_-bm-uf4w6f7HDJBVTb32ZEfzD6p4Bl_SjeT-uPr85_XTybnn28e37k_XZUjGMxVJQPGAFQinet9TwduhWoqMGCO5EIwam2xXlRVCEDHxgogXWGQU9M2Cgaehx9ewwd4zh206nLLc2Ke0ceB12SXLMGtIyWsAn_4CbsIvli5IkK065aHlbIHGAVAwpRW3kGO0W4pUkWE4py42cwpRTmHJKWf5OWV4W6-N5_q7f6uHWOMdagKczAEmBK0l6ZdMtJzgrL-WFe3XgLqzTV_99Abn-sD6dSvoLa1jLSA</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Jonnavithula, N.</creator><creator>Durga, P.</creator><creator>Kulkarni, D. K.</creator><creator>Ramachandran, G.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Bilateral intra‐oral, infra‐orbital nerve block for postoperative analgesia following cleft lip repair in paediatric patients: comparison of bupivacaine vs bupivacaine–pethidine combination</title><author>Jonnavithula, N. ; Durga, P. ; Kulkarni, D. K. ; Ramachandran, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5008-830d0ca8cc7b43f74d69863fa106828d5e49373f7c11d7d584a56fcab5fafa223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analgesics</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthesiology</topic><topic>Anesthetics, Combined - administration & dosage</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Birth defects</topic><topic>Bupivacaine - administration & dosage</topic><topic>Child, Preschool</topic><topic>Cleft Lip - surgery</topic><topic>Clinical trials</topic><topic>Comparative studies</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meperidine - administration & dosage</topic><topic>Nerve Block - methods</topic><topic>Nervous system</topic><topic>Pain</topic><topic>Pain Measurement - methods</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Side effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jonnavithula, N.</creatorcontrib><creatorcontrib>Durga, P.</creatorcontrib><creatorcontrib>Kulkarni, D. K.</creatorcontrib><creatorcontrib>Ramachandran, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jonnavithula, N.</au><au>Durga, P.</au><au>Kulkarni, D. K.</au><au>Ramachandran, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bilateral intra‐oral, infra‐orbital nerve block for postoperative analgesia following cleft lip repair in paediatric patients: comparison of bupivacaine vs bupivacaine–pethidine combination</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2007-06</date><risdate>2007</risdate><volume>62</volume><issue>6</issue><spage>581</spage><epage>585</epage><pages>581-585</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
This prospective, randomised, double blind study compared the efficacy of pethidine as an adjuvant to bupivacaine with the efficacy of bupivacaine alone for infra‐orbital nerve block in alleviating postoperative pain in children undergoing cleft lip repair. Forty paediatric patients aged between 5 and 60 months undergoing cleft lip repair were randomly allocated to two groups of 20. After tracheal intubation, group B received bilateral intra‐oral, infra‐orbital nerve block with 1 ml of 0.25% bupivacaine on each side and group P received 1 ml of 0.25% bupivacaine along with 0.25 mg.kg−1 body weight pethidine. Sedation after recovery from anaesthesia was assessed using the University of Michigan Sedation Scale (UMSS) and pain was assessed postoperatively up to 36 h using the FLACC scale (Face, Legs, Activity, Cry, Consolability). The median (IQR) duration of analgesia from the time of administration of block in group B was 18 h (14.2–20) compared to 29.1 h (24–36) in group P (p = 0.001). Addition of pethidine as an adjunct to local anaesthetic significantly prolonged the duration of postoperative analgesia without any adverse effects.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17506736</pmid><doi>10.1111/j.1365-2044.2007.05028.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anaesthesia, 2007-06, Vol.62 (6), p.581-585 |
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| subjects | Analgesics Analgesics, Opioid - administration & dosage Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Anesthetics, Combined - administration & dosage Anesthetics, Local - administration & dosage Biological and medical sciences Birth defects Bupivacaine - administration & dosage Child, Preschool Cleft Lip - surgery Clinical trials Comparative studies Double-Blind Method Female Humans Infant Male Medical sciences Meperidine - administration & dosage Nerve Block - methods Nervous system Pain Pain Measurement - methods Pain, Postoperative - prevention & control Pediatrics Prospective Studies Side effects |
| title | Bilateral intra‐oral, infra‐orbital nerve block for postoperative analgesia following cleft lip repair in paediatric patients: comparison of bupivacaine vs bupivacaine–pethidine combination |
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