Clinicopathological roles of alterations of tumor suppressor gene p16 in papillary thyroid carcinoma

Alterations of the p16 gene are common in human cancers, but their roles in thyroid cancers have not been clearly defined. The aim of the present study was to investigate the clinicopathological roles of the p16 gene in papillary thyroid carcinoma (PTC). p16 gene alterations were investigated in 44...

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Veröffentlicht in:	Annals of surgical oncology 2007-05, Vol.14 (5), p.1772-1779
Hauptverfasser:	Lam, Alfred King Yin, Lo, Chung Yau, Leung, Pauline, Lang, Brian Hung Hin, Chan, Wai Fun, Luk, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Follicular - genetics Adenocarcinoma, Follicular - metabolism Adenocarcinoma, Follicular - pathology Adolescent Adult Aged Aged, 80 and over Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology Child Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism DNA Methylation DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Female Gene expression Humans Immunoenzyme Techniques Immunohistochemistry Lymph nodes Male Metastases Metastasis Middle Aged p16 Protein Papillary thyroid carcinoma Polymerase chain reaction Promoter Regions, Genetic Protein expression Proteins Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA-directed DNA polymerase Thyroid Thyroid cancer Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Tumor suppressor genes Tumors
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