Primary administration of Lactobacillus johnsonii NCC533 in weaning period suppresses the elevation of proinflammatory cytokines and CD86 gene expressions in skin lesions in NC/Nga mice
The administration of probiotic lactic acid bacteria (LAB) has been studied for its potential to prevent atopic dermatitis (AD). The objective of this study was to assess the inhibitory mechanism of a skin lesion by LAB using an experimental model that we previously demonstrated in NC/Nga mice. Lact...
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| description | The administration of probiotic lactic acid bacteria (LAB) has been studied for its potential to prevent atopic dermatitis (AD). The objective of this study was to assess the inhibitory mechanism of a skin lesion by LAB using an experimental model that we previously demonstrated in NC/Nga mice. Lactobacillus johnsonii NCC533 (La1) was administered orally to the La1 group from 20 to 22 days after birth, while phosphate-buffered saline was given to the control group. After the induction of skin lesions in 6-week-old mice, the expression of genes supposedly involved in AD was evaluated. Gene expression of the proinflammatory cytokines [interleukin-8 (IL-8), IL-12 and IL-23] was significantly enhanced in the lesional skin of the control group by the induction of the lesion, whereas gene expression of those in the La1 group was not elevated. Interestingly, expression of the costimulatory molecule CD86 showed a pattern similar to the expression of the cytokines in the lesional skin. Moreover, the La1 group showed a significantly lower gene expression of CD86 in Peyer's patches and mesenteric lymph nodes than the control group. The suppression of proinflammatory cytokines and CD86 by primary administration of La1 may significantly contribute to the inhibitory effect on the skin lesion. |
| doi_str_mv | 10.1111/j.1574-695X.2007.00233.x |
| format | Article |
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The objective of this study was to assess the inhibitory mechanism of a skin lesion by LAB using an experimental model that we previously demonstrated in NC/Nga mice. Lactobacillus johnsonii NCC533 (La1) was administered orally to the La1 group from 20 to 22 days after birth, while phosphate-buffered saline was given to the control group. After the induction of skin lesions in 6-week-old mice, the expression of genes supposedly involved in AD was evaluated. Gene expression of the proinflammatory cytokines [interleukin-8 (IL-8), IL-12 and IL-23] was significantly enhanced in the lesional skin of the control group by the induction of the lesion, whereas gene expression of those in the La1 group was not elevated. Interestingly, expression of the costimulatory molecule CD86 showed a pattern similar to the expression of the cytokines in the lesional skin. Moreover, the La1 group showed a significantly lower gene expression of CD86 in Peyer's patches and mesenteric lymph nodes than the control group. The suppression of proinflammatory cytokines and CD86 by primary administration of La1 may significantly contribute to the inhibitory effect on the skin lesion.</description><identifier>ISSN: 0928-8244</identifier><identifier>EISSN: 1574-695X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1111/j.1574-695X.2007.00233.x</identifier><identifier>PMID: 17425659</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Allergic diseases ; Animals ; Antigens, CD - biosynthesis ; Antigens, CD - genetics ; Antigens, CD - immunology ; Antigens, Differentiation - biosynthesis ; Antigens, Differentiation - genetics ; Antigens, Differentiation - immunology ; Atopic dermatitis ; B7-1 Antigen - biosynthesis ; B7-1 Antigen - genetics ; B7-1 Antigen - immunology ; B7-2 Antigen - biosynthesis ; B7-2 Antigen - genetics ; B7-2 Antigen - immunology ; Bacteria ; Biological and medical sciences ; CD28 Antigens - biosynthesis ; CD28 Antigens - genetics ; CD28 Antigens - immunology ; CD86 ; CD86 antigen ; CTLA-4 Antigen ; Cytokines ; Cytokines - biosynthesis ; Cytokines - genetics ; Cytokines - immunology ; Dermatitis ; Dermatitis, Atopic - genetics ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - pathology ; Dermatitis, Atopic - prevention & control ; Eczema ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Immunity, Mucosal ; Immunopathology ; Inflammation ; inhibition of atopic dermatitis ; Interleukin 12 ; Interleukin 23 ; Interleukin 8 ; Interleukins - biosynthesis ; Interleukins - genetics ; Interleukins - immunology ; Lactic acid ; Lactic acid bacteria ; Lactobacillus - immunology ; Lactobacillus johnsonii ; Lesions ; Lymph nodes ; Lymphoid Tissue - immunology ; Lymphoid Tissue - pathology ; Medical sciences ; Mice ; Microbiology ; Mites - immunology ; NC/Nga mouse ; Oral administration ; Peyer's patches ; Pregnancy ; Probiotics ; proinflammatory cytokine ; Reverse Transcriptase Polymerase Chain Reaction - methods ; Skin allergic diseases. Stinging insect allergies ; Skin diseases ; Skin lesions ; Weaning</subject><ispartof>FEMS immunology and medical microbiology, 2007-06, Vol.50 (1), p.67-76</ispartof><rights>2007 Federation of European Microbiological Societies 2007</rights><rights>2007 INIST-CNRS</rights><rights>2007 Federation of European Microbiological Societies</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4923-96b9106aebcd2f3e07d256142880ea9567b9c324e16e980fb7fdbd759fbb586b3</citedby><cites>FETCH-LOGICAL-c4923-96b9106aebcd2f3e07d256142880ea9567b9c324e16e980fb7fdbd759fbb586b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1574-695X.2007.00233.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-695X.2007.00233.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18740243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17425659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Ryo</creatorcontrib><creatorcontrib>Otsuka, Mai</creatorcontrib><creatorcontrib>Nishio, Ayako</creatorcontrib><creatorcontrib>Ushida, Kazunari</creatorcontrib><title>Primary administration of Lactobacillus johnsonii NCC533 in weaning period suppresses the elevation of proinflammatory cytokines and CD86 gene expressions in skin lesions in NC/Nga mice</title><title>FEMS immunology and medical microbiology</title><addtitle>FEMS Immunol Med Microbiol</addtitle><description>The administration of probiotic lactic acid bacteria (LAB) has been studied for its potential to prevent atopic dermatitis (AD). The objective of this study was to assess the inhibitory mechanism of a skin lesion by LAB using an experimental model that we previously demonstrated in NC/Nga mice. Lactobacillus johnsonii NCC533 (La1) was administered orally to the La1 group from 20 to 22 days after birth, while phosphate-buffered saline was given to the control group. After the induction of skin lesions in 6-week-old mice, the expression of genes supposedly involved in AD was evaluated. Gene expression of the proinflammatory cytokines [interleukin-8 (IL-8), IL-12 and IL-23] was significantly enhanced in the lesional skin of the control group by the induction of the lesion, whereas gene expression of those in the La1 group was not elevated. Interestingly, expression of the costimulatory molecule CD86 showed a pattern similar to the expression of the cytokines in the lesional skin. Moreover, the La1 group showed a significantly lower gene expression of CD86 in Peyer's patches and mesenteric lymph nodes than the control group. The suppression of proinflammatory cytokines and CD86 by primary administration of La1 may significantly contribute to the inhibitory effect on the skin lesion.</description><subject>Administration, Oral</subject><subject>Allergic diseases</subject><subject>Animals</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, Differentiation - biosynthesis</subject><subject>Antigens, Differentiation - genetics</subject><subject>Antigens, Differentiation - immunology</subject><subject>Atopic dermatitis</subject><subject>B7-1 Antigen - biosynthesis</subject><subject>B7-1 Antigen - genetics</subject><subject>B7-1 Antigen - immunology</subject><subject>B7-2 Antigen - biosynthesis</subject><subject>B7-2 Antigen - genetics</subject><subject>B7-2 Antigen - immunology</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>CD28 Antigens - biosynthesis</subject><subject>CD28 Antigens - genetics</subject><subject>CD28 Antigens - immunology</subject><subject>CD86</subject><subject>CD86 antigen</subject><subject>CTLA-4 Antigen</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - genetics</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Atopic - pathology</subject><subject>Dermatitis, Atopic - prevention & control</subject><subject>Eczema</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Immunity, Mucosal</subject><subject>Immunopathology</subject><subject>Inflammation</subject><subject>inhibition of atopic dermatitis</subject><subject>Interleukin 12</subject><subject>Interleukin 23</subject><subject>Interleukin 8</subject><subject>Interleukins - biosynthesis</subject><subject>Interleukins - genetics</subject><subject>Interleukins - immunology</subject><subject>Lactic acid</subject><subject>Lactic acid bacteria</subject><subject>Lactobacillus - immunology</subject><subject>Lactobacillus johnsonii</subject><subject>Lesions</subject><subject>Lymph nodes</subject><subject>Lymphoid Tissue - immunology</subject><subject>Lymphoid Tissue - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Mites - immunology</subject><subject>NC/Nga mouse</subject><subject>Oral administration</subject><subject>Peyer's patches</subject><subject>Pregnancy</subject><subject>Probiotics</subject><subject>proinflammatory cytokine</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Skin diseases</subject><subject>Skin lesions</subject><subject>Weaning</subject><issn>0928-8244</issn><issn>1574-695X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd-K1DAUh4so7rr6ChoQvets_jVpwJulurowjoIueBfSNJ3N2CY1ad2ZR_PtzGyHWRAFc5OEfN85J_yyDCC4QGmdbxao4DRnovi2wBDyBYSYkMX2QXZ6fHiYnUKBy7zElJ5kT2LcQAipgPBxdoI4xQUrxGn263OwvQo7oJreOhvHoEbrHfAtWCo9-lpp23VTBBt_46J31oJVVRWEAOvArVHOujUYTLC-AXEahmBiNBGMNwaYzvw8FhuCt67tVN-r0ad2ejf679YlVLkGVG9LBtbGJWl7VyJZcd8hJgZ05nhfVeertQK91eZp9qhVXTTPDvtZdn357mv1IV9-en9VXSxzTQUmuWC1QJApU-sGt8RA3qSvI4rLEholCsZroQmmBjEjStjWvG3qhheireuiZDU5y17PddMXfkwmjrK3UZuuU874KUoOCyQYYgl8-Qe48VNwaTaJCWSYCc55osqZ0sHHGEwrhzkBiaDchys3cp-h3Gco9-HKu3DlNqnPDw2mujfNvXhIMwGvDoCKWnVtUE7beM-VnEJMSeLezNyt7czuvweQl1cf0yHpZNb9NPxDzv82_YvZapWXah3SYNdfMEQkQZxyxslv9MnbKg</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Inoue, Ryo</creator><creator>Otsuka, Mai</creator><creator>Nishio, Ayako</creator><creator>Ushida, Kazunari</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Primary administration of Lactobacillus johnsonii NCC533 in weaning period suppresses the elevation of proinflammatory cytokines and CD86 gene expressions in skin lesions in NC/Nga mice</title><author>Inoue, Ryo ; Otsuka, Mai ; Nishio, Ayako ; Ushida, Kazunari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4923-96b9106aebcd2f3e07d256142880ea9567b9c324e16e980fb7fdbd759fbb586b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Administration, Oral</topic><topic>Allergic diseases</topic><topic>Animals</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, Differentiation - biosynthesis</topic><topic>Antigens, Differentiation - genetics</topic><topic>Antigens, Differentiation - immunology</topic><topic>Atopic dermatitis</topic><topic>B7-1 Antigen - biosynthesis</topic><topic>B7-1 Antigen - genetics</topic><topic>B7-1 Antigen - immunology</topic><topic>B7-2 Antigen - biosynthesis</topic><topic>B7-2 Antigen - genetics</topic><topic>B7-2 Antigen - immunology</topic><topic>Bacteria</topic><topic>Biological and medical sciences</topic><topic>CD28 Antigens - biosynthesis</topic><topic>CD28 Antigens - genetics</topic><topic>CD28 Antigens - immunology</topic><topic>CD86</topic><topic>CD86 antigen</topic><topic>CTLA-4 Antigen</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - genetics</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dermatitis, Atopic - pathology</topic><topic>Dermatitis, Atopic - prevention & control</topic><topic>Eczema</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Immunity, Mucosal</topic><topic>Immunopathology</topic><topic>Inflammation</topic><topic>inhibition of atopic dermatitis</topic><topic>Interleukin 12</topic><topic>Interleukin 23</topic><topic>Interleukin 8</topic><topic>Interleukins - biosynthesis</topic><topic>Interleukins - genetics</topic><topic>Interleukins - immunology</topic><topic>Lactic acid</topic><topic>Lactic acid bacteria</topic><topic>Lactobacillus - immunology</topic><topic>Lactobacillus johnsonii</topic><topic>Lesions</topic><topic>Lymph nodes</topic><topic>Lymphoid Tissue - immunology</topic><topic>Lymphoid Tissue - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Mites - immunology</topic><topic>NC/Nga mouse</topic><topic>Oral administration</topic><topic>Peyer's patches</topic><topic>Pregnancy</topic><topic>Probiotics</topic><topic>proinflammatory cytokine</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Skin diseases</topic><topic>Skin lesions</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Ryo</creatorcontrib><creatorcontrib>Otsuka, Mai</creatorcontrib><creatorcontrib>Nishio, Ayako</creatorcontrib><creatorcontrib>Ushida, Kazunari</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS immunology and medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Ryo</au><au>Otsuka, Mai</au><au>Nishio, Ayako</au><au>Ushida, Kazunari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary administration of Lactobacillus johnsonii NCC533 in weaning period suppresses the elevation of proinflammatory cytokines and CD86 gene expressions in skin lesions in NC/Nga mice</atitle><jtitle>FEMS immunology and medical microbiology</jtitle><addtitle>FEMS Immunol Med Microbiol</addtitle><date>2007-06</date><risdate>2007</risdate><volume>50</volume><issue>1</issue><spage>67</spage><epage>76</epage><pages>67-76</pages><issn>0928-8244</issn><eissn>1574-695X</eissn><eissn>2049-632X</eissn><abstract>The administration of probiotic lactic acid bacteria (LAB) has been studied for its potential to prevent atopic dermatitis (AD). The objective of this study was to assess the inhibitory mechanism of a skin lesion by LAB using an experimental model that we previously demonstrated in NC/Nga mice. Lactobacillus johnsonii NCC533 (La1) was administered orally to the La1 group from 20 to 22 days after birth, while phosphate-buffered saline was given to the control group. After the induction of skin lesions in 6-week-old mice, the expression of genes supposedly involved in AD was evaluated. Gene expression of the proinflammatory cytokines [interleukin-8 (IL-8), IL-12 and IL-23] was significantly enhanced in the lesional skin of the control group by the induction of the lesion, whereas gene expression of those in the La1 group was not elevated. Interestingly, expression of the costimulatory molecule CD86 showed a pattern similar to the expression of the cytokines in the lesional skin. Moreover, the La1 group showed a significantly lower gene expression of CD86 in Peyer's patches and mesenteric lymph nodes than the control group. The suppression of proinflammatory cytokines and CD86 by primary administration of La1 may significantly contribute to the inhibitory effect on the skin lesion.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>17425659</pmid><doi>10.1111/j.1574-695X.2007.00233.x</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0928-8244 |
| ispartof | FEMS immunology and medical microbiology, 2007-06, Vol.50 (1), p.67-76 |
| issn | 0928-8244 1574-695X 2049-632X |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library All Journals |
| subjects | Administration, Oral Allergic diseases Animals Antigens, CD - biosynthesis Antigens, CD - genetics Antigens, CD - immunology Antigens, Differentiation - biosynthesis Antigens, Differentiation - genetics Antigens, Differentiation - immunology Atopic dermatitis B7-1 Antigen - biosynthesis B7-1 Antigen - genetics B7-1 Antigen - immunology B7-2 Antigen - biosynthesis B7-2 Antigen - genetics B7-2 Antigen - immunology Bacteria Biological and medical sciences CD28 Antigens - biosynthesis CD28 Antigens - genetics CD28 Antigens - immunology CD86 CD86 antigen CTLA-4 Antigen Cytokines Cytokines - biosynthesis Cytokines - genetics Cytokines - immunology Dermatitis Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Dermatitis, Atopic - pathology Dermatitis, Atopic - prevention & control Eczema Female Fundamental and applied biological sciences. Psychology Gene Expression Immunity, Mucosal Immunopathology Inflammation inhibition of atopic dermatitis Interleukin 12 Interleukin 23 Interleukin 8 Interleukins - biosynthesis Interleukins - genetics Interleukins - immunology Lactic acid Lactic acid bacteria Lactobacillus - immunology Lactobacillus johnsonii Lesions Lymph nodes Lymphoid Tissue - immunology Lymphoid Tissue - pathology Medical sciences Mice Microbiology Mites - immunology NC/Nga mouse Oral administration Peyer's patches Pregnancy Probiotics proinflammatory cytokine Reverse Transcriptase Polymerase Chain Reaction - methods Skin allergic diseases. Stinging insect allergies Skin diseases Skin lesions Weaning |
| title | Primary administration of Lactobacillus johnsonii NCC533 in weaning period suppresses the elevation of proinflammatory cytokines and CD86 gene expressions in skin lesions in NC/Nga mice |
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