Chloroquine is therapeutic in murine experimental model of paracoccidioidomycosis

Chloroquine, due to its basic properties, has been shown to prevent the release of iron from holotransferrin, thereby interfering with normal iron metabolism in a variety of cell types. We have studied the effects of chloroquine on the evolution of experimental paracoccidioidomycosis by evaluating t...

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Veröffentlicht in:	FEMS immunology and medical microbiology 2007-06, Vol.50 (1), p.133-143
Hauptverfasser:	Dias-Melicio, Luciane Alarcão, Calvi, Sueli Aparecida, Bordon, Ana Paula, Golim, Marjorie A, Peraçoli, Maria Terezinha Serrão, Soares, Angela Maria Victoriano Campos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blastomycoses and paracoccidioidomycosis Chloroquine Chloroquine - pharmacology cytokines Disease Models, Animal Fundamental and applied biological sciences. Psychology Fungi Human mycoses Hydrogen peroxide Hydrogen Peroxide - metabolism Infectious diseases Interleukin 10 Interleukin 6 Interleukin-6 - metabolism Iron Iron - metabolism Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Male Medical sciences Metabolism Mice Mice, Inbred BALB C Microbiology Miscellaneous Mycology Mycoses nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - immunology Organs Paracoccidioides - isolation & purification Paracoccidioides brasiliensis Paracoccidioidomycosis - drug therapy Paracoccidioidomycosis - microbiology Peritoneum Receptors, Transferrin - biosynthesis Recovery South American blastomycosis Spleen Transferrin Transferrins Tropical mycoses Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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