Lung Fluid Immunoglobulin from HIV-Infected Subjects Has Impaired Opsonic Function against Pneumococci
Background. The incidence of pneumococcal pneumonia is greatly increased among human immunodeficiency virus (HIV)-infected subjects, compared with among non-HIV-infected subjects. Lung fluid levels of immunoglobulin G (IgG) specific for pneumococcal capsular polysaccharide are not reduced in HIV-inf...
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| Veröffentlicht in: | Clinical infectious diseases 2007-06, Vol.44 (12), p.1632-1638 |
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| creator | Eagan, Roger Twigg, Homer L. French, Neil Musaya, Janelisa Day, Richard B. Zijlstra, Eduard E. Tolmie, Helen Wyler, David Molyneux, Malcolm E. Gordon, Stephen B. |
| description | Background. The incidence of pneumococcal pneumonia is greatly increased among human immunodeficiency virus (HIV)-infected subjects, compared with among non-HIV-infected subjects. Lung fluid levels of immunoglobulin G (IgG) specific for pneumococcal capsular polysaccharide are not reduced in HIV-infected subjects; therefore, we examined immunoglobulin subtypes and compared lung fluid IgG opsonic function in HIV-infected subjects with that in healthy subjects. Methods. Bronchoalveolar lavage (BAL) fluid and serum samples were collected from 23 HIV-infected and 26 uninfected subjects. None of the subjects were receiving highly active antiretroviral therapy, and none had received pneumococcal vaccination. Pneumococcal capsule-specific IgG levels in serum and BAL fluid were measured by enzyme-linked immunosorbent assay, and IgG was concentrated from 40 mL of BAL fluid. Opsonization and opsonophagocytosis of pneumococci with serum, BAL fluid, and BAL IgG were compared between HIV-infected subjects and healthy subjects. Results. The effect of type 1 pneumococcal capsular polysaccharide-specific IgG in opsonizing of pneumococci was significantly less using both serum and BAL IgG from HIV-infected subjects, compared with serum and BAL IgG from healthy subjects (mean level, 8.9 fluorescence units [95% confidence interval, 8.1–9.7 fluorescence units] vs. 12.1 fluorescence units [95% confidence interval, 9.7–15.2 fluorescence units]; P = .002 for lung BAL IgG). The opsonophagocytosis of pneumococci observed using BAL IgG from HIV-infected subjects was significantly less than that observed using BAL IgG from healthy subjects (37 fluorescence units per ng of IgG [95% confidence interval, 25–53 fluorescence units per ng of IgG] vs. 127 fluorescence units per ng of IgG [95% confidence interval, 109–145 fluorescence units per ng of IgG]; P < .001). Conclusion. HIV infection is associated with decreased antipneumococcal opsonic function in BAL fluid and serum. |
| doi_str_mv | 10.1086/518133 |
| format | Article |
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The incidence of pneumococcal pneumonia is greatly increased among human immunodeficiency virus (HIV)-infected subjects, compared with among non-HIV-infected subjects. Lung fluid levels of immunoglobulin G (IgG) specific for pneumococcal capsular polysaccharide are not reduced in HIV-infected subjects; therefore, we examined immunoglobulin subtypes and compared lung fluid IgG opsonic function in HIV-infected subjects with that in healthy subjects. Methods. Bronchoalveolar lavage (BAL) fluid and serum samples were collected from 23 HIV-infected and 26 uninfected subjects. None of the subjects were receiving highly active antiretroviral therapy, and none had received pneumococcal vaccination. Pneumococcal capsule-specific IgG levels in serum and BAL fluid were measured by enzyme-linked immunosorbent assay, and IgG was concentrated from 40 mL of BAL fluid. Opsonization and opsonophagocytosis of pneumococci with serum, BAL fluid, and BAL IgG were compared between HIV-infected subjects and healthy subjects. Results. The effect of type 1 pneumococcal capsular polysaccharide-specific IgG in opsonizing of pneumococci was significantly less using both serum and BAL IgG from HIV-infected subjects, compared with serum and BAL IgG from healthy subjects (mean level, 8.9 fluorescence units [95% confidence interval, 8.1–9.7 fluorescence units] vs. 12.1 fluorescence units [95% confidence interval, 9.7–15.2 fluorescence units]; P = .002 for lung BAL IgG). The opsonophagocytosis of pneumococci observed using BAL IgG from HIV-infected subjects was significantly less than that observed using BAL IgG from healthy subjects (37 fluorescence units per ng of IgG [95% confidence interval, 25–53 fluorescence units per ng of IgG] vs. 127 fluorescence units per ng of IgG [95% confidence interval, 109–145 fluorescence units per ng of IgG]; P < .001). Conclusion. HIV infection is associated with decreased antipneumococcal opsonic function in BAL fluid and serum.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/518133</identifier><identifier>PMID: 17516409</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; Bacteria ; Bacterial Capsules - immunology ; Biological and medical sciences ; Body fluids ; Bronchoalveolar Lavage Fluid - immunology ; Case-Control Studies ; Clinical outcomes ; Female ; Fluorescence ; HIV ; HIV infections ; HIV Infections - immunology ; HIV Infections - microbiology ; HIV/AIDS ; Human immunodeficiency virus ; Human subjects ; Human viral diseases ; Humans ; Immunoassay ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulin G - analysis ; Immunoglobulin G - immunology ; Immunoglobulins ; Immunopathology ; Infections ; Infectious diseases ; Lungs ; Male ; Medical sciences ; Opsonin Proteins - analysis ; Opsonin Proteins - immunology ; Phagocytosis - immunology ; Pneumonia ; Polysaccharides ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Vaccination ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Clinical infectious diseases, 2007-06, Vol.44 (12), p.1632-1638</ispartof><rights>Copyright 2007 The Infectious Diseases Society of America</rights><rights>2007 Infectious Diseases Society of America 2007</rights><rights>2008 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jun 15, 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-1eff620848c071fa40965a523976907c3e097766ec049a57407fae8b7bb603723</citedby><cites>FETCH-LOGICAL-c513t-1eff620848c071fa40965a523976907c3e097766ec049a57407fae8b7bb603723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4485460$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4485460$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20291174$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17516409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eagan, Roger</creatorcontrib><creatorcontrib>Twigg, Homer L.</creatorcontrib><creatorcontrib>French, Neil</creatorcontrib><creatorcontrib>Musaya, Janelisa</creatorcontrib><creatorcontrib>Day, Richard B.</creatorcontrib><creatorcontrib>Zijlstra, Eduard E.</creatorcontrib><creatorcontrib>Tolmie, Helen</creatorcontrib><creatorcontrib>Wyler, David</creatorcontrib><creatorcontrib>Molyneux, Malcolm E.</creatorcontrib><creatorcontrib>Gordon, Stephen B.</creatorcontrib><title>Lung Fluid Immunoglobulin from HIV-Infected Subjects Has Impaired Opsonic Function against Pneumococci</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Background. The incidence of pneumococcal pneumonia is greatly increased among human immunodeficiency virus (HIV)-infected subjects, compared with among non-HIV-infected subjects. Lung fluid levels of immunoglobulin G (IgG) specific for pneumococcal capsular polysaccharide are not reduced in HIV-infected subjects; therefore, we examined immunoglobulin subtypes and compared lung fluid IgG opsonic function in HIV-infected subjects with that in healthy subjects. Methods. Bronchoalveolar lavage (BAL) fluid and serum samples were collected from 23 HIV-infected and 26 uninfected subjects. None of the subjects were receiving highly active antiretroviral therapy, and none had received pneumococcal vaccination. Pneumococcal capsule-specific IgG levels in serum and BAL fluid were measured by enzyme-linked immunosorbent assay, and IgG was concentrated from 40 mL of BAL fluid. Opsonization and opsonophagocytosis of pneumococci with serum, BAL fluid, and BAL IgG were compared between HIV-infected subjects and healthy subjects. Results. The effect of type 1 pneumococcal capsular polysaccharide-specific IgG in opsonizing of pneumococci was significantly less using both serum and BAL IgG from HIV-infected subjects, compared with serum and BAL IgG from healthy subjects (mean level, 8.9 fluorescence units [95% confidence interval, 8.1–9.7 fluorescence units] vs. 12.1 fluorescence units [95% confidence interval, 9.7–15.2 fluorescence units]; P = .002 for lung BAL IgG). The opsonophagocytosis of pneumococci observed using BAL IgG from HIV-infected subjects was significantly less than that observed using BAL IgG from healthy subjects (37 fluorescence units per ng of IgG [95% confidence interval, 25–53 fluorescence units per ng of IgG] vs. 127 fluorescence units per ng of IgG [95% confidence interval, 109–145 fluorescence units per ng of IgG]; P < .001). Conclusion. HIV infection is associated with decreased antipneumococcal opsonic function in BAL fluid and serum.</description><subject>Adult</subject><subject>AIDS</subject><subject>Bacteria</subject><subject>Bacterial Capsules - immunology</subject><subject>Biological and medical sciences</subject><subject>Body fluids</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Case-Control Studies</subject><subject>Clinical outcomes</subject><subject>Female</subject><subject>Fluorescence</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - microbiology</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus</subject><subject>Human subjects</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulins</subject><subject>Immunopathology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Opsonin Proteins - analysis</subject><subject>Opsonin Proteins - immunology</subject><subject>Phagocytosis - immunology</subject><subject>Pneumonia</subject><subject>Polysaccharides</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Vaccination</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V-L1DAQAPAgineu-glEqqBv1aT5_yiHaxcWztNTDl9Cmk2WrG1Skwb029ujyyqC3FOGzI_JTAaApwi-QVCwtxQJhPE9cI4o5jWjEt2fY0hFTQQWZ-BRzgcIERKQPgRniFPECJTnwG1L2FfrvvhdtRmGEuK-j13pfahcikPVbr7Wm-Csmeyu-ly6wxzlqtV51qP2ab69HHMM3lTrEszkY6j0XvuQp-pjsGWIJhrjH4MHTvfZPjmeK_Bl_f76oq23lx82F--2taEITzWyzrEGCiIM5MjpuUVGNW2w5ExCbrCFknPGrIFEasoJ5E5b0fGuYxDzBq_A66XumOKPYvOkBp-N7XsdbCxZcUgREUzcCRvIEBaNvBMiySmk-Ba-_AceYklhnlY1SEouYPNXfybFnJN1akx-0OmXQlDdLlIti5zh82O10g1294cdNzeDV0egs9G9SzoYn0-ugY1EiJPZvVhcLOP_H3u2mEOeYjopQgQl87-uQL2kfZ7sz1Nap--Kccypam--qZsr_qlpr6_UFv8GWyPEzg</recordid><startdate>20070615</startdate><enddate>20070615</enddate><creator>Eagan, Roger</creator><creator>Twigg, Homer L.</creator><creator>French, Neil</creator><creator>Musaya, Janelisa</creator><creator>Day, Richard B.</creator><creator>Zijlstra, Eduard E.</creator><creator>Tolmie, Helen</creator><creator>Wyler, David</creator><creator>Molyneux, Malcolm E.</creator><creator>Gordon, Stephen B.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>20070615</creationdate><title>Lung Fluid Immunoglobulin from HIV-Infected Subjects Has Impaired Opsonic Function against Pneumococci</title><author>Eagan, Roger ; Twigg, Homer L. ; French, Neil ; Musaya, Janelisa ; Day, Richard B. ; Zijlstra, Eduard E. ; Tolmie, Helen ; Wyler, David ; Molyneux, Malcolm E. ; Gordon, Stephen B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-1eff620848c071fa40965a523976907c3e097766ec049a57407fae8b7bb603723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>Bacteria</topic><topic>Bacterial Capsules - immunology</topic><topic>Biological and medical sciences</topic><topic>Body fluids</topic><topic>Bronchoalveolar Lavage Fluid - immunology</topic><topic>Case-Control Studies</topic><topic>Clinical outcomes</topic><topic>Female</topic><topic>Fluorescence</topic><topic>HIV</topic><topic>HIV infections</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - microbiology</topic><topic>HIV/AIDS</topic><topic>Human immunodeficiency virus</topic><topic>Human subjects</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulins</topic><topic>Immunopathology</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Opsonin Proteins - analysis</topic><topic>Opsonin Proteins - immunology</topic><topic>Phagocytosis - immunology</topic><topic>Pneumonia</topic><topic>Polysaccharides</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Vaccination</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eagan, Roger</creatorcontrib><creatorcontrib>Twigg, Homer L.</creatorcontrib><creatorcontrib>French, Neil</creatorcontrib><creatorcontrib>Musaya, Janelisa</creatorcontrib><creatorcontrib>Day, Richard B.</creatorcontrib><creatorcontrib>Zijlstra, Eduard E.</creatorcontrib><creatorcontrib>Tolmie, Helen</creatorcontrib><creatorcontrib>Wyler, David</creatorcontrib><creatorcontrib>Molyneux, Malcolm E.</creatorcontrib><creatorcontrib>Gordon, Stephen B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eagan, Roger</au><au>Twigg, Homer L.</au><au>French, Neil</au><au>Musaya, Janelisa</au><au>Day, Richard B.</au><au>Zijlstra, Eduard E.</au><au>Tolmie, Helen</au><au>Wyler, David</au><au>Molyneux, Malcolm E.</au><au>Gordon, Stephen B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung Fluid Immunoglobulin from HIV-Infected Subjects Has Impaired Opsonic Function against Pneumococci</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2007-06-15</date><risdate>2007</risdate><volume>44</volume><issue>12</issue><spage>1632</spage><epage>1638</epage><pages>1632-1638</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Background. The incidence of pneumococcal pneumonia is greatly increased among human immunodeficiency virus (HIV)-infected subjects, compared with among non-HIV-infected subjects. Lung fluid levels of immunoglobulin G (IgG) specific for pneumococcal capsular polysaccharide are not reduced in HIV-infected subjects; therefore, we examined immunoglobulin subtypes and compared lung fluid IgG opsonic function in HIV-infected subjects with that in healthy subjects. Methods. Bronchoalveolar lavage (BAL) fluid and serum samples were collected from 23 HIV-infected and 26 uninfected subjects. None of the subjects were receiving highly active antiretroviral therapy, and none had received pneumococcal vaccination. Pneumococcal capsule-specific IgG levels in serum and BAL fluid were measured by enzyme-linked immunosorbent assay, and IgG was concentrated from 40 mL of BAL fluid. Opsonization and opsonophagocytosis of pneumococci with serum, BAL fluid, and BAL IgG were compared between HIV-infected subjects and healthy subjects. Results. The effect of type 1 pneumococcal capsular polysaccharide-specific IgG in opsonizing of pneumococci was significantly less using both serum and BAL IgG from HIV-infected subjects, compared with serum and BAL IgG from healthy subjects (mean level, 8.9 fluorescence units [95% confidence interval, 8.1–9.7 fluorescence units] vs. 12.1 fluorescence units [95% confidence interval, 9.7–15.2 fluorescence units]; P = .002 for lung BAL IgG). The opsonophagocytosis of pneumococci observed using BAL IgG from HIV-infected subjects was significantly less than that observed using BAL IgG from healthy subjects (37 fluorescence units per ng of IgG [95% confidence interval, 25–53 fluorescence units per ng of IgG] vs. 127 fluorescence units per ng of IgG [95% confidence interval, 109–145 fluorescence units per ng of IgG]; P < .001). Conclusion. HIV infection is associated with decreased antipneumococcal opsonic function in BAL fluid and serum.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>17516409</pmid><doi>10.1086/518133</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult AIDS Bacteria Bacterial Capsules - immunology Biological and medical sciences Body fluids Bronchoalveolar Lavage Fluid - immunology Case-Control Studies Clinical outcomes Female Fluorescence HIV HIV infections HIV Infections - immunology HIV Infections - microbiology HIV/AIDS Human immunodeficiency virus Human subjects Human viral diseases Humans Immunoassay Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin G - analysis Immunoglobulin G - immunology Immunoglobulins Immunopathology Infections Infectious diseases Lungs Male Medical sciences Opsonin Proteins - analysis Opsonin Proteins - immunology Phagocytosis - immunology Pneumonia Polysaccharides Streptococcus pneumoniae Streptococcus pneumoniae - immunology Vaccination Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Lung Fluid Immunoglobulin from HIV-Infected Subjects Has Impaired Opsonic Function against Pneumococci |
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