Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma
Summary Background Allergic conditions in different organs share many similarities in their inflammatory response. Vernal keratoconjunctivitis (VKC), asthma and nasal polyps exhibit several similar, but site‐specific mucosal structural changes. The aim of the study was to investigate whether matrix...
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| Veröffentlicht in: | Clinical and experimental allergy 2007-06, Vol.37 (6), p.872-879 |
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| creator | Leonardi, A. Brun, P. Di Stefano, A. Motterle, L. Abatangelo, G. |
| description | Summary
Background
Allergic conditions in different organs share many similarities in their inflammatory response. Vernal keratoconjunctivitis (VKC), asthma and nasal polyps exhibit several similar, but site‐specific mucosal structural changes. The aim of the study was to investigate whether matrix metalloproteases contribute to different tissue remodelling aspects in different organs.
Methods
Mucosal biopsies were obtained from conjunctiva of healthy donors, tarsal conjunctiva of vernal patients, bronchi of non‐asthmatic subjects, bronchi of mild stable asthmatic patients, nasal mucosa of non‐allergic donors and nasal polyps of allergic patients. Distribution of metalloprotease‐1, ‐3, ‐9, ‐13, tissue inhibitor of metalloproteases‐1, collagens I and III and the presence of eosinophils and CD4+ cells were evaluated by immunohistochemistry.
Results
Collagens were highly diffuse in the giant papillae of VKC and in nasal polyps, and yet less increased in the subepithelium of asthmatic patients. Immunostaining for metalloprotease‐1, ‐3, ‐9 and ‐13 was significantly higher in VKC compared with normal conjunctiva. Metalloprotease‐9 staining was higher in the stroma of polyps vs. normal nasal mucosa, and only metalloprotease‐13 was significantly more expressed in asthmatic vs. non‐asthmatic subjects. Metalloprotease‐9 immunostaining was more intense in vernal compared with other tissues. In all pathological tissues, metalloprotease‐9‐positive staining was in association with eosinophils and CD4+ cells.
Conclusions
Expression of metalloproteases may play an important role in inducing the structural changes seen in VKC, nasal polyps and asthma. Tissue remodelling and gelatinase immunoexpression was more dramatic in giant papillae of vernal patients compared with other tissue sites of chronic allergic inflammation. |
| doi_str_mv | 10.1111/j.1365-2222.2007.02732.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70514734</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20420480</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3812-4915e792f56805924af9f5ea347cc80db5cd0ad994a96ed1fdf550cbaeaf08ae3</originalsourceid><addsrcrecordid>eNqNkE1v1DAQhi0EokvhLyBf4ESCndhxfOBQRWVbqYBUgejNmnUm4G0-tra37P77OuyqPcLIki3N84xHLyGUs5yn-rjOeVnJrEiVF4ypnBWqLPLdM7J4bDwnC6alyFStxQl5FcKaMVZKXb8kJ1xJrjjjC3LzBaJ3OzpghL6fNn6KCAEDdSO9Rz9CT2_RQ5zsNK63o43u3kUXPtARQuptpn6_CRTGliYd_S9nKYT4e4DX5EUHfcA3x_uU_Ph8_r25yK6-LS-bs6vMljUvMqG5RKWLTlY1k7oQ0OlOIpRCWVuzdiVty6DVWoCusOVd20nJ7AoQOlYDlqfk_WFuWv1uiyGawQWLfQ8jTttgFJNcqFL8EyyYSKdmCawPoPVTCB47s_FuAL83nJk5frM2c8pmTtnM8Zu_8ZtdUt8e_9iuBmyfxGPeCXh3BCBY6DsPo3XhiauVqiqlEvfpwP1xPe7_ewHTnJ_Nr-RnB9-FiLtHH_ytqVSppPn5dWkurpvm-mZZmaZ8APbdsUU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20420480</pqid></control><display><type>article</type><title>Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Leonardi, A. ; Brun, P. ; Di Stefano, A. ; Motterle, L. ; Abatangelo, G.</creator><creatorcontrib>Leonardi, A. ; Brun, P. ; Di Stefano, A. ; Motterle, L. ; Abatangelo, G.</creatorcontrib><description>Summary
Background
Allergic conditions in different organs share many similarities in their inflammatory response. Vernal keratoconjunctivitis (VKC), asthma and nasal polyps exhibit several similar, but site‐specific mucosal structural changes. The aim of the study was to investigate whether matrix metalloproteases contribute to different tissue remodelling aspects in different organs.
Methods
Mucosal biopsies were obtained from conjunctiva of healthy donors, tarsal conjunctiva of vernal patients, bronchi of non‐asthmatic subjects, bronchi of mild stable asthmatic patients, nasal mucosa of non‐allergic donors and nasal polyps of allergic patients. Distribution of metalloprotease‐1, ‐3, ‐9, ‐13, tissue inhibitor of metalloproteases‐1, collagens I and III and the presence of eosinophils and CD4+ cells were evaluated by immunohistochemistry.
Results
Collagens were highly diffuse in the giant papillae of VKC and in nasal polyps, and yet less increased in the subepithelium of asthmatic patients. Immunostaining for metalloprotease‐1, ‐3, ‐9 and ‐13 was significantly higher in VKC compared with normal conjunctiva. Metalloprotease‐9 staining was higher in the stroma of polyps vs. normal nasal mucosa, and only metalloprotease‐13 was significantly more expressed in asthmatic vs. non‐asthmatic subjects. Metalloprotease‐9 immunostaining was more intense in vernal compared with other tissues. In all pathological tissues, metalloprotease‐9‐positive staining was in association with eosinophils and CD4+ cells.
Conclusions
Expression of metalloproteases may play an important role in inducing the structural changes seen in VKC, nasal polyps and asthma. Tissue remodelling and gelatinase immunoexpression was more dramatic in giant papillae of vernal patients compared with other tissue sites of chronic allergic inflammation.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.2007.02732.x</identifier><identifier>PMID: 17517101</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Allergic diseases ; Asthma - enzymology ; Asthma - immunology ; Asthma - pathology ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - enzymology ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - pathology ; Child ; collagen ; Collagen Type I - immunology ; Collagen Type I - metabolism ; Collagen Type III - immunology ; Collagen Type III - metabolism ; Conjunctivitis, Allergic - enzymology ; Conjunctivitis, Allergic - immunology ; Conjunctivitis, Allergic - pathology ; Eosinophils - enzymology ; Eosinophils - immunology ; Eosinophils - pathology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunohistochemistry ; Immunopathology ; Male ; Matrix Metalloproteinases - immunology ; Matrix Metalloproteinases - metabolism ; Medical sciences ; Middle Aged ; MMP ; Mucous Membrane - enzymology ; Mucous Membrane - immunology ; Mucous Membrane - pathology ; nasal polyps ; Nasal Polyps - enzymology ; Nasal Polyps - immunology ; Nasal Polyps - pathology ; Organ Specificity - immunology ; Tissue Inhibitor of Metalloproteinase-1 - immunology ; Tissue Inhibitor of Metalloproteinase-1 - metabolism ; tissue remodelling ; vernal keratoconjunctivitis</subject><ispartof>Clinical and experimental allergy, 2007-06, Vol.37 (6), p.872-879</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3812-4915e792f56805924af9f5ea347cc80db5cd0ad994a96ed1fdf550cbaeaf08ae3</citedby><cites>FETCH-LOGICAL-c3812-4915e792f56805924af9f5ea347cc80db5cd0ad994a96ed1fdf550cbaeaf08ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.2007.02732.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.2007.02732.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18776677$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17517101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leonardi, A.</creatorcontrib><creatorcontrib>Brun, P.</creatorcontrib><creatorcontrib>Di Stefano, A.</creatorcontrib><creatorcontrib>Motterle, L.</creatorcontrib><creatorcontrib>Abatangelo, G.</creatorcontrib><title>Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Background
Allergic conditions in different organs share many similarities in their inflammatory response. Vernal keratoconjunctivitis (VKC), asthma and nasal polyps exhibit several similar, but site‐specific mucosal structural changes. The aim of the study was to investigate whether matrix metalloproteases contribute to different tissue remodelling aspects in different organs.
Methods
Mucosal biopsies were obtained from conjunctiva of healthy donors, tarsal conjunctiva of vernal patients, bronchi of non‐asthmatic subjects, bronchi of mild stable asthmatic patients, nasal mucosa of non‐allergic donors and nasal polyps of allergic patients. Distribution of metalloprotease‐1, ‐3, ‐9, ‐13, tissue inhibitor of metalloproteases‐1, collagens I and III and the presence of eosinophils and CD4+ cells were evaluated by immunohistochemistry.
Results
Collagens were highly diffuse in the giant papillae of VKC and in nasal polyps, and yet less increased in the subepithelium of asthmatic patients. Immunostaining for metalloprotease‐1, ‐3, ‐9 and ‐13 was significantly higher in VKC compared with normal conjunctiva. Metalloprotease‐9 staining was higher in the stroma of polyps vs. normal nasal mucosa, and only metalloprotease‐13 was significantly more expressed in asthmatic vs. non‐asthmatic subjects. Metalloprotease‐9 immunostaining was more intense in vernal compared with other tissues. In all pathological tissues, metalloprotease‐9‐positive staining was in association with eosinophils and CD4+ cells.
Conclusions
Expression of metalloproteases may play an important role in inducing the structural changes seen in VKC, nasal polyps and asthma. Tissue remodelling and gelatinase immunoexpression was more dramatic in giant papillae of vernal patients compared with other tissue sites of chronic allergic inflammation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergic diseases</subject><subject>Asthma - enzymology</subject><subject>Asthma - immunology</subject><subject>Asthma - pathology</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - enzymology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>Child</subject><subject>collagen</subject><subject>Collagen Type I - immunology</subject><subject>Collagen Type I - metabolism</subject><subject>Collagen Type III - immunology</subject><subject>Collagen Type III - metabolism</subject><subject>Conjunctivitis, Allergic - enzymology</subject><subject>Conjunctivitis, Allergic - immunology</subject><subject>Conjunctivitis, Allergic - pathology</subject><subject>Eosinophils - enzymology</subject><subject>Eosinophils - immunology</subject><subject>Eosinophils - pathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Matrix Metalloproteinases - immunology</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MMP</subject><subject>Mucous Membrane - enzymology</subject><subject>Mucous Membrane - immunology</subject><subject>Mucous Membrane - pathology</subject><subject>nasal polyps</subject><subject>Nasal Polyps - enzymology</subject><subject>Nasal Polyps - immunology</subject><subject>Nasal Polyps - pathology</subject><subject>Organ Specificity - immunology</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - immunology</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - metabolism</subject><subject>tissue remodelling</subject><subject>vernal keratoconjunctivitis</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyBf4ESCndhxfOBQRWVbqYBUgejNmnUm4G0-tra37P77OuyqPcLIki3N84xHLyGUs5yn-rjOeVnJrEiVF4ypnBWqLPLdM7J4bDwnC6alyFStxQl5FcKaMVZKXb8kJ1xJrjjjC3LzBaJ3OzpghL6fNn6KCAEDdSO9Rz9CT2_RQ5zsNK63o43u3kUXPtARQuptpn6_CRTGliYd_S9nKYT4e4DX5EUHfcA3x_uU_Ph8_r25yK6-LS-bs6vMljUvMqG5RKWLTlY1k7oQ0OlOIpRCWVuzdiVty6DVWoCusOVd20nJ7AoQOlYDlqfk_WFuWv1uiyGawQWLfQ8jTttgFJNcqFL8EyyYSKdmCawPoPVTCB47s_FuAL83nJk5frM2c8pmTtnM8Zu_8ZtdUt8e_9iuBmyfxGPeCXh3BCBY6DsPo3XhiauVqiqlEvfpwP1xPe7_ewHTnJ_Nr-RnB9-FiLtHH_ytqVSppPn5dWkurpvm-mZZmaZ8APbdsUU</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Leonardi, A.</creator><creator>Brun, P.</creator><creator>Di Stefano, A.</creator><creator>Motterle, L.</creator><creator>Abatangelo, G.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma</title><author>Leonardi, A. ; Brun, P. ; Di Stefano, A. ; Motterle, L. ; Abatangelo, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3812-4915e792f56805924af9f5ea347cc80db5cd0ad994a96ed1fdf550cbaeaf08ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergic diseases</topic><topic>Asthma - enzymology</topic><topic>Asthma - immunology</topic><topic>Asthma - pathology</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - enzymology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>Child</topic><topic>collagen</topic><topic>Collagen Type I - immunology</topic><topic>Collagen Type I - metabolism</topic><topic>Collagen Type III - immunology</topic><topic>Collagen Type III - metabolism</topic><topic>Conjunctivitis, Allergic - enzymology</topic><topic>Conjunctivitis, Allergic - immunology</topic><topic>Conjunctivitis, Allergic - pathology</topic><topic>Eosinophils - enzymology</topic><topic>Eosinophils - immunology</topic><topic>Eosinophils - pathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Matrix Metalloproteinases - immunology</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MMP</topic><topic>Mucous Membrane - enzymology</topic><topic>Mucous Membrane - immunology</topic><topic>Mucous Membrane - pathology</topic><topic>nasal polyps</topic><topic>Nasal Polyps - enzymology</topic><topic>Nasal Polyps - immunology</topic><topic>Nasal Polyps - pathology</topic><topic>Organ Specificity - immunology</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - immunology</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - metabolism</topic><topic>tissue remodelling</topic><topic>vernal keratoconjunctivitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leonardi, A.</creatorcontrib><creatorcontrib>Brun, P.</creatorcontrib><creatorcontrib>Di Stefano, A.</creatorcontrib><creatorcontrib>Motterle, L.</creatorcontrib><creatorcontrib>Abatangelo, G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leonardi, A.</au><au>Brun, P.</au><au>Di Stefano, A.</au><au>Motterle, L.</au><au>Abatangelo, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2007-06</date><risdate>2007</risdate><volume>37</volume><issue>6</issue><spage>872</spage><epage>879</epage><pages>872-879</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Background
Allergic conditions in different organs share many similarities in their inflammatory response. Vernal keratoconjunctivitis (VKC), asthma and nasal polyps exhibit several similar, but site‐specific mucosal structural changes. The aim of the study was to investigate whether matrix metalloproteases contribute to different tissue remodelling aspects in different organs.
Methods
Mucosal biopsies were obtained from conjunctiva of healthy donors, tarsal conjunctiva of vernal patients, bronchi of non‐asthmatic subjects, bronchi of mild stable asthmatic patients, nasal mucosa of non‐allergic donors and nasal polyps of allergic patients. Distribution of metalloprotease‐1, ‐3, ‐9, ‐13, tissue inhibitor of metalloproteases‐1, collagens I and III and the presence of eosinophils and CD4+ cells were evaluated by immunohistochemistry.
Results
Collagens were highly diffuse in the giant papillae of VKC and in nasal polyps, and yet less increased in the subepithelium of asthmatic patients. Immunostaining for metalloprotease‐1, ‐3, ‐9 and ‐13 was significantly higher in VKC compared with normal conjunctiva. Metalloprotease‐9 staining was higher in the stroma of polyps vs. normal nasal mucosa, and only metalloprotease‐13 was significantly more expressed in asthmatic vs. non‐asthmatic subjects. Metalloprotease‐9 immunostaining was more intense in vernal compared with other tissues. In all pathological tissues, metalloprotease‐9‐positive staining was in association with eosinophils and CD4+ cells.
Conclusions
Expression of metalloproteases may play an important role in inducing the structural changes seen in VKC, nasal polyps and asthma. Tissue remodelling and gelatinase immunoexpression was more dramatic in giant papillae of vernal patients compared with other tissue sites of chronic allergic inflammation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17517101</pmid><doi>10.1111/j.1365-2222.2007.02732.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical and experimental allergy, 2007-06, Vol.37 (6), p.872-879 |
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| subjects | Adolescent Adult Allergic diseases Asthma - enzymology Asthma - immunology Asthma - pathology Biological and medical sciences CD4-Positive T-Lymphocytes - enzymology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Child collagen Collagen Type I - immunology Collagen Type I - metabolism Collagen Type III - immunology Collagen Type III - metabolism Conjunctivitis, Allergic - enzymology Conjunctivitis, Allergic - immunology Conjunctivitis, Allergic - pathology Eosinophils - enzymology Eosinophils - immunology Eosinophils - pathology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunohistochemistry Immunopathology Male Matrix Metalloproteinases - immunology Matrix Metalloproteinases - metabolism Medical sciences Middle Aged MMP Mucous Membrane - enzymology Mucous Membrane - immunology Mucous Membrane - pathology nasal polyps Nasal Polyps - enzymology Nasal Polyps - immunology Nasal Polyps - pathology Organ Specificity - immunology Tissue Inhibitor of Metalloproteinase-1 - immunology Tissue Inhibitor of Metalloproteinase-1 - metabolism tissue remodelling vernal keratoconjunctivitis |
| title | Matrix metalloproteases in vernal keratoconjunctivitis, nasal polyps and allergic asthma |
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