The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

Forkhead-associated (FHA) domains are a class of ubiquitous signaling modules that appear to function through interactions with phosphorylated target molecules. We have used oriented peptide library screening to determine the optimal phosphopeptide binding motifs recognized by several FHA domains, i...

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Veröffentlicht in:	Molecular cell 2000-11, Vol.6 (5), p.1169-1182
Hauptverfasser:	Durocher, D, Taylor, I A, Sarbassova, D, Haire, L F, Westcott, S L, Jackson, S P, Smerdon, S J, Yaffe, M B
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins Amino Acid Motifs Amino Acid Sequence Arginine - genetics Arginine - metabolism Binding Sites Cell Cycle Proteins Checkpoint Kinase 2 Crystallization Crystallography, X-Ray FHA1 protein Forkhead Transcription Factors Humans Models, Molecular Molecular Sequence Data Mutation - genetics Nuclear Proteins - chemistry Peptide Library Phosphopeptides - chemistry Phosphopeptides - genetics Phosphopeptides - metabolism Phosphothreonine - chemistry Phosphothreonine - metabolism Protein Binding Protein Interaction Mapping Protein Kinases - chemistry Protein Kinases - genetics Protein Kinases - metabolism Protein Structure, Secondary Protein Structure, Tertiary Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Rad53 protein Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal Transduction src Homology Domains Substrate Specificity Transcription Factors - chemistry Tyrosine 3-Monooxygenase - chemistry Tyrosine 3-Monooxygenase - metabolism
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