AZD2171 Shows Potent Antitumor Activity Against Gastric Cancer Over-Expressing Fibroblast Growth Factor Receptor 2/Keratinocyte Growth Factor Receptor

Purpose: AZD2171 is an oral, highly potent, and selective vascular endothelial growth factor signaling inhibitor that inhibits all vascular endothelial growth factor receptor tyrosine kinases. The purpose of this study was to investigate the activity of AZD2171 in gastric cancer. Experimental Design...

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Veröffentlicht in:	Clinical cancer research 2007-05, Vol.13 (10), p.3051-3057
Hauptverfasser:	TAKEDA, Masayuki, ARAO, Tokuzo, SAIJO, Nagahiro, NISHIOL, Kazuto, YOKOTE, Hideyuki, KOMATSU, Teruo, YANAGIHARA, Kazuyoshi, SASAKI, Hiroki, YAMADA, Yasuhide, TAMURA, Tomohide, FUKUOKA, Kazuya, KIMURA, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use AZD2171 Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Dimerization FGFR2 gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Mice Mice, Inbred Strains Pharmacology. Drug treatments Quinazolines - administration & dosage Quinazolines - pharmacology Quinazolines - therapeutic use Receptor, Fibroblast Growth Factor, Type 2 - analysis Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 2 - metabolism RNA, Small Interfering - pharmacology Stomach Neoplasms - drug therapy Stomach Neoplasms - enzymology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Up-Regulation - drug effects VEGF VEGFR-2 Xenograft Model Antitumor Assays
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