G-quadruplexes as therapeutic targets

The ends of chromosomes (telomeres) consist of tandem repeats of guanine‐rich sequences. In eukaryotics, telomeric DNA is single stranded for the final few hundred bases. These single‐stranded sequences can fold into a variety of four‐stranded structures (quadruplexes) held together by quartets of h...

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Veröffentlicht in:	Biopolymers 2000, Vol.56 (3), p.195-208
Hauptverfasser:	Neidle, Stephen, Read, Martin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthraquinones - chemistry Anthraquinones - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology DNA - chemistry DNA - drug effects DNA quadruplex G-Quadruplexes Guanine - chemistry Humans ligand binding Ligands Nucleic Acid Conformation - drug effects quadruplexes rational design telomerase Telomerase - antagonists & inhibitors telomere Telomere - chemistry Telomere - drug effects
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