Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years
The neurofibroma occurs as isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF-1). The aim of this study was to analyze the clinical and histopathological features of neurofibromas, particularly the plexiform variant, in the skin and oral mucosa, discussing their pat...
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Veröffentlicht in: | Clinical oral investigations 2007-06, Vol.11 (2), p.165-169 |
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description | The neurofibroma occurs as isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF-1). The aim of this study was to analyze the clinical and histopathological features of neurofibromas, particularly the plexiform variant, in the skin and oral mucosa, discussing their pathogenesis as well as clinical management of isolated lesion unassociated with NF1. The clinicopathologic features of 66 neurofibromas in the head and neck region diagnosed at the pathology laboratories of the Bauru Dentistry School and Lauro de Souza Lima Research Institute from 1970 to 2003 were reviewed. The clinical data, therapy, and follow-up information were obtained from the medical records. The results showed a high frequency of cutaneous lesions (81.8%) occurring mainly in females older than 40 years. Isolated neurofibromas were found in 51.2% of patients, and multiple lesions were often associated with the NF-1. The histopathological analysis demonstrated that diffused neurofibromas occur more frequently than the plexiform type. However, one case of plexiform neurofibroma was detected in the oral mucosa as an isolated lesion non-associated with the NF-1. The indolent clinical behavior of isolated neurofibromas in the head and neck region and the absence of NF-1 association reinforce that sporadic lesion could be hyperplastic or hamartomatous rather than neoplastic in nature. |
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The aim of this study was to analyze the clinical and histopathological features of neurofibromas, particularly the plexiform variant, in the skin and oral mucosa, discussing their pathogenesis as well as clinical management of isolated lesion unassociated with NF1. The clinicopathologic features of 66 neurofibromas in the head and neck region diagnosed at the pathology laboratories of the Bauru Dentistry School and Lauro de Souza Lima Research Institute from 1970 to 2003 were reviewed. The clinical data, therapy, and follow-up information were obtained from the medical records. The results showed a high frequency of cutaneous lesions (81.8%) occurring mainly in females older than 40 years. Isolated neurofibromas were found in 51.2% of patients, and multiple lesions were often associated with the NF-1. The histopathological analysis demonstrated that diffused neurofibromas occur more frequently than the plexiform type. However, one case of plexiform neurofibroma was detected in the oral mucosa as an isolated lesion non-associated with the NF-1. The indolent clinical behavior of isolated neurofibromas in the head and neck region and the absence of NF-1 association reinforce that sporadic lesion could be hyperplastic or hamartomatous rather than neoplastic in nature.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-006-0096-6</identifier><identifier>PMID: 17285268</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Dentistry ; Female ; Genetic disorders ; Head and neck ; Head and Neck Neoplasms - pathology ; Humans ; Lesions ; Male ; Medical records ; Mouth Mucosa - pathology ; Mucosa ; Neurofibroma - pathology ; Neurofibroma, Plexiform - pathology ; Neurofibromatosis ; Neurofibromatosis 1 - pathology ; Neurological disorders ; Plexiform neurofibroma ; Recklinghausen's disease ; Retrospective Studies ; Skin Neoplasms - pathology ; Tumors</subject><ispartof>Clinical oral investigations, 2007-06, Vol.11 (2), p.165-169</ispartof><rights>Springer-Verlag 2007</rights><rights>Springer-Verlag 2007.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-7754911cd71e92e0f4ae1e7b0913103d4fb77dd095d1bf4c576c166698a034d33</citedby><cites>FETCH-LOGICAL-c354t-7754911cd71e92e0f4ae1e7b0913103d4fb77dd095d1bf4c576c166698a034d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17285268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marocchio, Luciana Sassa</creatorcontrib><creatorcontrib>Oliveira, Denise Tostes</creatorcontrib><creatorcontrib>Pereira, Michele Conceição</creatorcontrib><creatorcontrib>Soares, Cléverson Teixeira</creatorcontrib><creatorcontrib>Fleury, Raul Negrão</creatorcontrib><title>Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years</title><title>Clinical oral investigations</title><addtitle>Clin Oral Investig</addtitle><description>The neurofibroma occurs as isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF-1). The aim of this study was to analyze the clinical and histopathological features of neurofibromas, particularly the plexiform variant, in the skin and oral mucosa, discussing their pathogenesis as well as clinical management of isolated lesion unassociated with NF1. The clinicopathologic features of 66 neurofibromas in the head and neck region diagnosed at the pathology laboratories of the Bauru Dentistry School and Lauro de Souza Lima Research Institute from 1970 to 2003 were reviewed. The clinical data, therapy, and follow-up information were obtained from the medical records. The results showed a high frequency of cutaneous lesions (81.8%) occurring mainly in females older than 40 years. Isolated neurofibromas were found in 51.2% of patients, and multiple lesions were often associated with the NF-1. The histopathological analysis demonstrated that diffused neurofibromas occur more frequently than the plexiform type. However, one case of plexiform neurofibroma was detected in the oral mucosa as an isolated lesion non-associated with the NF-1. The indolent clinical behavior of isolated neurofibromas in the head and neck region and the absence of NF-1 association reinforce that sporadic lesion could be hyperplastic or hamartomatous rather than neoplastic in nature.</description><subject>Adult</subject><subject>Dentistry</subject><subject>Female</subject><subject>Genetic disorders</subject><subject>Head and neck</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Lesions</subject><subject>Male</subject><subject>Medical records</subject><subject>Mouth Mucosa - pathology</subject><subject>Mucosa</subject><subject>Neurofibroma - pathology</subject><subject>Neurofibroma, Plexiform - pathology</subject><subject>Neurofibromatosis</subject><subject>Neurofibromatosis 1 - pathology</subject><subject>Neurological disorders</subject><subject>Plexiform neurofibroma</subject><subject>Recklinghausen's disease</subject><subject>Retrospective Studies</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctKxTAQQIMovj_AjQQFd9VMkyatOxFfILhQ1yFNplptm5q0wv17o_eCILiYzCzODJM5hBwAOwXG1FlMTykyxmSKSmZyjWyD4DLjSsH6T51nsiphi-zE-MYYCKn4JtkClZdFLsttUj-OPhjXWmoGR_u5m9qxQzrgHHzT1sH3JtJ2oNMr0lc07gcb0L7TgC-tH86pSdUUfBzRTu0n0jjNbkF9QzmnCzQh7pGNxnQR91d5lzxfXz1d3mb3Dzd3lxf3meWFmDKlClEBWKcAqxxZIwwCqppVwIFxJ5paKedYVTioG2ELJS1Imb5nGBeO811yspw7Bv8xY5x030aLXWcG9HPUihXAKlUm8PgP-ObnMKTddC5lwaVM50nU0b9UXkmRA4MEwRKy6QIxYKPH0PYmLDQw_e1ILx3p5Eh_O9Iy9RyuBs91j-63YyWFfwFxh4qG</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Marocchio, Luciana Sassa</creator><creator>Oliveira, Denise Tostes</creator><creator>Pereira, Michele Conceição</creator><creator>Soares, Cléverson Teixeira</creator><creator>Fleury, Raul Negrão</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years</title><author>Marocchio, Luciana Sassa ; Oliveira, Denise Tostes ; Pereira, Michele Conceição ; Soares, Cléverson Teixeira ; Fleury, Raul Negrão</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-7754911cd71e92e0f4ae1e7b0913103d4fb77dd095d1bf4c576c166698a034d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Dentistry</topic><topic>Female</topic><topic>Genetic disorders</topic><topic>Head and neck</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Lesions</topic><topic>Male</topic><topic>Medical records</topic><topic>Mouth Mucosa - pathology</topic><topic>Mucosa</topic><topic>Neurofibroma - pathology</topic><topic>Neurofibroma, Plexiform - pathology</topic><topic>Neurofibromatosis</topic><topic>Neurofibromatosis 1 - pathology</topic><topic>Neurological disorders</topic><topic>Plexiform neurofibroma</topic><topic>Recklinghausen's disease</topic><topic>Retrospective Studies</topic><topic>Skin Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marocchio, Luciana Sassa</creatorcontrib><creatorcontrib>Oliveira, Denise Tostes</creatorcontrib><creatorcontrib>Pereira, Michele Conceição</creatorcontrib><creatorcontrib>Soares, Cléverson Teixeira</creatorcontrib><creatorcontrib>Fleury, Raul Negrão</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marocchio, Luciana Sassa</au><au>Oliveira, Denise Tostes</au><au>Pereira, Michele Conceição</au><au>Soares, Cléverson Teixeira</au><au>Fleury, Raul Negrão</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years</atitle><jtitle>Clinical oral investigations</jtitle><addtitle>Clin Oral Investig</addtitle><date>2007-06</date><risdate>2007</risdate><volume>11</volume><issue>2</issue><spage>165</spage><epage>169</epage><pages>165-169</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>The neurofibroma occurs as isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF-1). The aim of this study was to analyze the clinical and histopathological features of neurofibromas, particularly the plexiform variant, in the skin and oral mucosa, discussing their pathogenesis as well as clinical management of isolated lesion unassociated with NF1. The clinicopathologic features of 66 neurofibromas in the head and neck region diagnosed at the pathology laboratories of the Bauru Dentistry School and Lauro de Souza Lima Research Institute from 1970 to 2003 were reviewed. The clinical data, therapy, and follow-up information were obtained from the medical records. The results showed a high frequency of cutaneous lesions (81.8%) occurring mainly in females older than 40 years. Isolated neurofibromas were found in 51.2% of patients, and multiple lesions were often associated with the NF-1. The histopathological analysis demonstrated that diffused neurofibromas occur more frequently than the plexiform type. However, one case of plexiform neurofibroma was detected in the oral mucosa as an isolated lesion non-associated with the NF-1. The indolent clinical behavior of isolated neurofibromas in the head and neck region and the absence of NF-1 association reinforce that sporadic lesion could be hyperplastic or hamartomatous rather than neoplastic in nature.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>17285268</pmid><doi>10.1007/s00784-006-0096-6</doi><tpages>5</tpages></addata></record> |
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subjects | Adult Dentistry Female Genetic disorders Head and neck Head and Neck Neoplasms - pathology Humans Lesions Male Medical records Mouth Mucosa - pathology Mucosa Neurofibroma - pathology Neurofibroma, Plexiform - pathology Neurofibromatosis Neurofibromatosis 1 - pathology Neurological disorders Plexiform neurofibroma Recklinghausen's disease Retrospective Studies Skin Neoplasms - pathology Tumors |
title | Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years |
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