Wnt signals provide a timing mechanism for the FGF-retinoid differentiation switch during vertebrate body axis extension

Differentiation onset in the vertebrate body axis is controlled by a conserved switch from fibroblast growth factor (FGF) to retinoid signalling, which is also apparent in the extending limb and aberrant in many cancer cell lines. FGF protects tail-end stem zone cells from precocious differentiation...

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Veröffentlicht in:	Development (Cambridge) 2007-06, Vol.134 (11), p.2125-2135
Hauptverfasser:	Olivera-Martinez, Isabel, Storey, Kate G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning - physiology Cell Differentiation - physiology Chick Embryo Electroporation Fibroblast Growth Factors - metabolism Gene Expression Regulation, Developmental - physiology Immunohistochemistry In Situ Hybridization Neurons - cytology Neurons - metabolism Signal Transduction - physiology Tretinoin - metabolism Wnt Proteins - metabolism
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