Dysregulated growth factor gene expression is associated with tubulointerstitial apoptosis and renal dysfunction

Chronic renal disease is characterized by declining renal function, loss of intrinsic renal cells, and their replacement with fibrotic tissue. This study investigates apoptosis and its regulation in the context of chronic renal disease. RNA was extracted from renal biopsies from patients with variou...

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Veröffentlicht in:	Kidney international 2007-05, Vol.71 (10), p.1044-1053
Hauptverfasser:	Teteris, S.A., Menahem, S.A., Perry, G., Maguire, J.A., Dowling, J.P., Langham, R.G., Thomson, N.M., Stein, A.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over apoptosis Apoptosis - genetics Biological and medical sciences Biomarkers - blood Biopsy Chronic Disease chronic renal disease epidermal growth factor Epidermal Growth Factor - genetics Female Gene Expression Gene Expression Regulation Glomerular Filtration Rate Humans Intercellular Signaling Peptides and Proteins - genetics Kidney - pathology Kidney - physiopathology Kidney Diseases - complications Kidney Diseases - genetics Kidney Diseases - pathology Kidney Diseases - physiopathology Kidney Tubules - physiopathology Kidneys Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Proteinuria - etiology Renal failure RNA, Messenger - metabolism TGF beta TNF alpha Transforming Growth Factor beta1 - genetics Treatment Outcome Tumor Necrosis Factor-alpha - genetics Urinary system involvement in other diseases. Miscellaneous
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