Mice lacking cyclin-dependent kinase inhibitor p19Ink4d show strain-specific effects on male reproduction

p19Ink4d is a member of the INK4 family of cyclin‐dependent kinase inhibitors, which are important negative regulators of the G1‐phase cyclin‐dependent kinases CDK4 and CDK6. On a mixed C57BL/6 × 129P2/OlaHsd background, mice deficient for p19Ink4d exhibited defects in male reproductive function inc...

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Veröffentlicht in:	Molecular reproduction and development 2007-08, Vol.74 (8), p.1008-1020
Hauptverfasser:	Buchold, Gregory M., Magyar, Patricia L., O'Brien, Deborah A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Biomarkers - metabolism cell cycle Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase 6 - metabolism Cyclin-Dependent Kinase Inhibitor p19 - genetics Cyclin-Dependent Kinase Inhibitor p19 - metabolism Female Fertility - physiology Follicle Stimulating Hormone - blood Fundamental and applied biological sciences. Psychology gene targeting Germ Cells - physiology Hormone metabolism and regulation Litter Size Male Mammalian male genital system Meiosis Mice Mice, Inbred Strains Mice, Knockout Organ Size Reproduction Species Specificity spermatogenesis Testis - anatomy & histology Testis - metabolism Testis - pathology Testosterone - blood Vertebrates: reproduction
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