Biphasic effects of haloperidol on sodium currents in guinea pig ventricular myocytes

Aim: To study the effects of haloperidol on sodium currents (INa) in guinea pig ventricular myocytes. Method: Whole‐cell patch clamp technique was employed to evaluate the effects of haloperidol on INa in individual ventricular myocytes. Results: Haloperidol (0.1‐3 μmol/L) inhibited INa in a concent...

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Veröffentlicht in:	Acta pharmacologica Sinica 2007-06, Vol.28 (6), p.783-788
Hauptverfasser:	CHENG, Lu‐feng, YAN, Dong, TURDI, Subat, KERRAM, Parhat
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Guinea Pigs haloperidol Haloperidol - pharmacology Heart Ventricles - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Patch-Clamp Techniques Sodium Channels - metabolism sodium current ventricular myocytes
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