ESAT-6 and CFP-10 can be combined to reduce the cost of testing for Mycobacterium tuberculosis infection, but CFP-10 responses associate with active disease

Commercial tests measuring IFN-γ responses to ESAT-6 and CFP-10 are available for diagnosing Mycobacterium tuberculosis infection. Measures that minimize cost and complexity will facilitate their application in less-developed countries. We investigated whether overlapping peptides representing both...

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Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 2007-07, Vol.101 (7), p.691-698
Hauptverfasser:	Fox, Annette, Jeffries, David J., Hill, Philip C., Hammond, Abdulrahman S., Lugos, Moses D., Jackson-Sillah, Dolly, Donkor, Simon A., Owiafe, Patrick K., McAdam, Keith P.W.J., Brookes, Roger H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antigens, Bacterial - analysis Bacterial diseases Bacterial Proteins - analysis Biological and medical sciences CFP-10 Child Disease ELISPOT Enzyme-Linked Immunosorbent Assay - methods ESAT-6 Female Gambia Human bacterial diseases Humans Infection Infectious diseases Male Medical sciences Mycobacterium tuberculosis - immunology Sensitivity and Specificity Tuberculin Test Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - transmission
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