Conditional Overexpression of the Wild-Type Gsα as the gsp Oncogene Initiates Chronic Extracellularly Regulated Kinase 1/2 Activation and Hormone Hypersecretion in Pituitary Cell Lines

In pituitary cells, activation of the cAMP pathway by specific G protein-coupled receptors controls differentiative functions and proliferation. Constitutively active forms of the α subunit of the heterotrimeric Gs protein resulting from mutations at codon 201 or 227 (gsp oncogene) were first identi...

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