Effect of Exercise Training on Autonomic Derangement and Neurohumoral Activation in Chronic Heart Failure
Abstract Background In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at va...
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| Veröffentlicht in: | Journal of cardiac failure 2007-05, Vol.13 (4), p.294-303 |
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| creator | Gademan, Maaike G.J., MSc Swenne, Cees A., PhD Verwey, Harriette F., MD van der Laarse, Arnoud, PhD Maan, Arie C., PhD van de Vooren, Hedde, MSc van Pelt, Johannes, PhD van Exel, Henk J., MD Lucas, Caroline M.H.B., MD Cleuren, Ger V.J., RN Somer, Soeresh, MD Schalij, Martin J., MD van der Wall, Ernst E., MD |
| description | Abstract Background In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structural levels. However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect. Methods and Results After reviewing the available evidence we conclude that exercise training increases baroreflex sensitivity and heart rate variability, and reduces sympathetic outflow, plasma levels of catecholamines, angiotensin II, vasopressin, and brain natriuretic peptides at rest. Conclusions Exercise training has direct and reflex sympathoinhibitory beneficial effects in CHF. The mechanism by which exercise training normalizes autonomic derangement and neurohumoral activation is to elucidate for further development of CHF-related training programs aimed at maximizing efficacy while minimizing workload. |
| doi_str_mv | 10.1016/j.cardfail.2006.12.006 |
| format | Article |
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Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structural levels. However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect. Methods and Results After reviewing the available evidence we conclude that exercise training increases baroreflex sensitivity and heart rate variability, and reduces sympathetic outflow, plasma levels of catecholamines, angiotensin II, vasopressin, and brain natriuretic peptides at rest. Conclusions Exercise training has direct and reflex sympathoinhibitory beneficial effects in CHF. The mechanism by which exercise training normalizes autonomic derangement and neurohumoral activation is to elucidate for further development of CHF-related training programs aimed at maximizing efficacy while minimizing workload.</description><identifier>ISSN: 1071-9164</identifier><identifier>EISSN: 1532-8414</identifier><identifier>DOI: 10.1016/j.cardfail.2006.12.006</identifier><identifier>PMID: 17517350</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Arginine - metabolism ; Autonomic Nervous System Diseases - etiology ; Autonomic Nervous System Diseases - physiopathology ; Autonomic Nervous System Diseases - therapy ; Baroreflex ; baroreflex sensitivity ; BNP ; Cardiovascular ; Catecholamines - metabolism ; Chronic Disease ; Endothelins - metabolism ; Exercise Therapy ; exercise training ; Heart Failure - complications ; Heart Failure - metabolism ; Heart Failure - physiopathology ; Heart Failure - therapy ; Heart Rate ; Humans ; Natriuretic Peptide, Brain - metabolism ; neurohormones ; Neurotransmitter Agents - metabolism ; RAAS ; Rehabilitation ; Renin-Angiotensin System ; sympathetic outflow ; Treatment Outcome ; variability ; Vasopressins - metabolism</subject><ispartof>Journal of cardiac failure, 2007-05, Vol.13 (4), p.294-303</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-7ab03a03d9fe7c595e8841e9c46bc7859b81ed7f2242cbceb40bd17758bad2513</citedby><cites>FETCH-LOGICAL-c487t-7ab03a03d9fe7c595e8841e9c46bc7859b81ed7f2242cbceb40bd17758bad2513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S107191640601298X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17517350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gademan, Maaike G.J., MSc</creatorcontrib><creatorcontrib>Swenne, Cees A., PhD</creatorcontrib><creatorcontrib>Verwey, Harriette F., MD</creatorcontrib><creatorcontrib>van der Laarse, Arnoud, PhD</creatorcontrib><creatorcontrib>Maan, Arie C., PhD</creatorcontrib><creatorcontrib>van de Vooren, Hedde, MSc</creatorcontrib><creatorcontrib>van Pelt, Johannes, PhD</creatorcontrib><creatorcontrib>van Exel, Henk J., MD</creatorcontrib><creatorcontrib>Lucas, Caroline M.H.B., MD</creatorcontrib><creatorcontrib>Cleuren, Ger V.J., RN</creatorcontrib><creatorcontrib>Somer, Soeresh, MD</creatorcontrib><creatorcontrib>Schalij, Martin J., MD</creatorcontrib><creatorcontrib>van der Wall, Ernst E., MD</creatorcontrib><title>Effect of Exercise Training on Autonomic Derangement and Neurohumoral Activation in Chronic Heart Failure</title><title>Journal of cardiac failure</title><addtitle>J Card Fail</addtitle><description>Abstract Background In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structural levels. However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect. Methods and Results After reviewing the available evidence we conclude that exercise training increases baroreflex sensitivity and heart rate variability, and reduces sympathetic outflow, plasma levels of catecholamines, angiotensin II, vasopressin, and brain natriuretic peptides at rest. Conclusions Exercise training has direct and reflex sympathoinhibitory beneficial effects in CHF. The mechanism by which exercise training normalizes autonomic derangement and neurohumoral activation is to elucidate for further development of CHF-related training programs aimed at maximizing efficacy while minimizing workload.</description><subject>Arginine - metabolism</subject><subject>Autonomic Nervous System Diseases - etiology</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Autonomic Nervous System Diseases - therapy</subject><subject>Baroreflex</subject><subject>baroreflex sensitivity</subject><subject>BNP</subject><subject>Cardiovascular</subject><subject>Catecholamines - metabolism</subject><subject>Chronic Disease</subject><subject>Endothelins - metabolism</subject><subject>Exercise Therapy</subject><subject>exercise training</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - metabolism</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Natriuretic Peptide, Brain - metabolism</subject><subject>neurohormones</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>RAAS</subject><subject>Rehabilitation</subject><subject>Renin-Angiotensin System</subject><subject>sympathetic outflow</subject><subject>Treatment Outcome</subject><subject>variability</subject><subject>Vasopressins - metabolism</subject><issn>1071-9164</issn><issn>1532-8414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EoqXwFyqfuCWMnThOLojVdksrVXCgSNwsx560XhK72ElF_z2OdiskLpyeD-_NeL5HyDmDkgFrPuxLo6MdtBtLDtCUjJdZXpBTJipetDWrX-Y3SFZ0rKlPyJuU9gDQ1iBfkxMmBZOVgFPidsOAZqZhoLvfGI1LSG-jdt75Oxo83Sxz8GFyhl5g1P4OJ_Qz1d7SL7jEcL9MIeqRbszsHvXscsJ5ur2PwefIFeo408v8ySXiW_Jq0GPCd0c9I98vd7fbq-Lm6-fr7eamMHUr50LqHioNle0GlEZ0Att8DXambnojW9H1LUMrB85rbnqDfQ29ZVKKtteWC1adkfeHuQ8x_FowzWpyyeA4ao9hSUqCgA5gNTYHo4khpYiDeohu0vFJMVArZLVXz5DVClkxrrLk4Plxw9JPaP_GjlSz4dPBgPnOR4dRJePQG7QuZtjKBvf_HR__GWHGXIrR4098wrQPS_SZomIq5YD6tla9Ng0NMN61P6o_ZVKm-w</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Gademan, Maaike G.J., MSc</creator><creator>Swenne, Cees A., PhD</creator><creator>Verwey, Harriette F., MD</creator><creator>van der Laarse, Arnoud, PhD</creator><creator>Maan, Arie C., PhD</creator><creator>van de Vooren, Hedde, MSc</creator><creator>van Pelt, Johannes, PhD</creator><creator>van Exel, Henk J., MD</creator><creator>Lucas, Caroline M.H.B., MD</creator><creator>Cleuren, Ger V.J., RN</creator><creator>Somer, Soeresh, MD</creator><creator>Schalij, Martin J., MD</creator><creator>van der Wall, Ernst E., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Effect of Exercise Training on Autonomic Derangement and Neurohumoral Activation in Chronic Heart Failure</title><author>Gademan, Maaike G.J., MSc ; Swenne, Cees A., PhD ; Verwey, Harriette F., MD ; van der Laarse, Arnoud, PhD ; Maan, Arie C., PhD ; van de Vooren, Hedde, MSc ; van Pelt, Johannes, PhD ; van Exel, Henk J., MD ; Lucas, Caroline M.H.B., MD ; Cleuren, Ger V.J., RN ; Somer, Soeresh, MD ; Schalij, Martin J., MD ; van der Wall, Ernst E., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-7ab03a03d9fe7c595e8841e9c46bc7859b81ed7f2242cbceb40bd17758bad2513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Arginine - metabolism</topic><topic>Autonomic Nervous System Diseases - etiology</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Autonomic Nervous System Diseases - therapy</topic><topic>Baroreflex</topic><topic>baroreflex sensitivity</topic><topic>BNP</topic><topic>Cardiovascular</topic><topic>Catecholamines - metabolism</topic><topic>Chronic Disease</topic><topic>Endothelins - metabolism</topic><topic>Exercise Therapy</topic><topic>exercise training</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - metabolism</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Natriuretic Peptide, Brain - metabolism</topic><topic>neurohormones</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>RAAS</topic><topic>Rehabilitation</topic><topic>Renin-Angiotensin System</topic><topic>sympathetic outflow</topic><topic>Treatment Outcome</topic><topic>variability</topic><topic>Vasopressins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gademan, Maaike G.J., MSc</creatorcontrib><creatorcontrib>Swenne, Cees A., PhD</creatorcontrib><creatorcontrib>Verwey, Harriette F., MD</creatorcontrib><creatorcontrib>van der Laarse, Arnoud, PhD</creatorcontrib><creatorcontrib>Maan, Arie C., PhD</creatorcontrib><creatorcontrib>van de Vooren, Hedde, MSc</creatorcontrib><creatorcontrib>van Pelt, Johannes, PhD</creatorcontrib><creatorcontrib>van Exel, Henk J., MD</creatorcontrib><creatorcontrib>Lucas, Caroline M.H.B., MD</creatorcontrib><creatorcontrib>Cleuren, Ger V.J., RN</creatorcontrib><creatorcontrib>Somer, Soeresh, MD</creatorcontrib><creatorcontrib>Schalij, Martin J., MD</creatorcontrib><creatorcontrib>van der Wall, Ernst E., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiac failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gademan, Maaike G.J., MSc</au><au>Swenne, Cees A., PhD</au><au>Verwey, Harriette F., MD</au><au>van der Laarse, Arnoud, PhD</au><au>Maan, Arie C., PhD</au><au>van de Vooren, Hedde, MSc</au><au>van Pelt, Johannes, PhD</au><au>van Exel, Henk J., MD</au><au>Lucas, Caroline M.H.B., MD</au><au>Cleuren, Ger V.J., RN</au><au>Somer, Soeresh, MD</au><au>Schalij, Martin J., MD</au><au>van der Wall, Ernst E., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Exercise Training on Autonomic Derangement and Neurohumoral Activation in Chronic Heart Failure</atitle><jtitle>Journal of cardiac failure</jtitle><addtitle>J Card Fail</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>13</volume><issue>4</issue><spage>294</spage><epage>303</epage><pages>294-303</pages><issn>1071-9164</issn><eissn>1532-8414</eissn><abstract>Abstract Background In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structural levels. However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect. Methods and Results After reviewing the available evidence we conclude that exercise training increases baroreflex sensitivity and heart rate variability, and reduces sympathetic outflow, plasma levels of catecholamines, angiotensin II, vasopressin, and brain natriuretic peptides at rest. Conclusions Exercise training has direct and reflex sympathoinhibitory beneficial effects in CHF. The mechanism by which exercise training normalizes autonomic derangement and neurohumoral activation is to elucidate for further development of CHF-related training programs aimed at maximizing efficacy while minimizing workload.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17517350</pmid><doi>10.1016/j.cardfail.2006.12.006</doi><tpages>10</tpages></addata></record> |
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| subjects | Arginine - metabolism Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - physiopathology Autonomic Nervous System Diseases - therapy Baroreflex baroreflex sensitivity BNP Cardiovascular Catecholamines - metabolism Chronic Disease Endothelins - metabolism Exercise Therapy exercise training Heart Failure - complications Heart Failure - metabolism Heart Failure - physiopathology Heart Failure - therapy Heart Rate Humans Natriuretic Peptide, Brain - metabolism neurohormones Neurotransmitter Agents - metabolism RAAS Rehabilitation Renin-Angiotensin System sympathetic outflow Treatment Outcome variability Vasopressins - metabolism |
| title | Effect of Exercise Training on Autonomic Derangement and Neurohumoral Activation in Chronic Heart Failure |
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