A Novel Functional CTL Avidity/Activity Compartmentalization to the Site of Mucosal Immunization Contributes to Protection of Macaques against Simian/Human Immunodeficiency Viral Depletion of Mucosal CD4+ T Cells

The presence of high-avidity CTLs in the right compartment can greatly affect clearance of a virus infection (for example, AIDS viral infection of and dissemination from mucosa). Comparing mucosal vs systemic immunization, we observed a novel compartmentalization of CTL avidity and proportion of fun...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2007-06, Vol.178 (11), p.7211-7221
Hauptverfasser:	Belyakov, Igor M, Isakov, Dmitry, Zhu, Qing, Dzutsev, Amiran, Berzofsky, Jay A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Rectal AIDS Vaccines - administration & dosage AIDS Vaccines - immunology Amino Acid Sequence Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Cell Adhesion - immunology Cytotoxicity, Immunologic Female Humans Immunity, Mucosal Injections, Subcutaneous Interferon-gamma - metabolism Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Lymphocyte Activation - immunology Lymphocyte Depletion Macaca mulatta Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Sequence Data SAIDS Vaccines - administration & dosage SAIDS Vaccines - immunology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Cytotoxic - virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!