Blockade of CD11a by Efalizumab in Psoriasis Patients Induces a Unique State of T-Cell Hyporesponsiveness

Efalizumab (anti-CD11a) interferes with LFA-1/ICAM-1 binding and inhibits several key steps in psoriasis pathogenesis. This study characterizes the effects of efalizumab on T-cell activation responses and expression of surface markers on human circulating psoriatic T cells during a therapeutic trial...

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Veröffentlicht in:	Journal of investigative dermatology 2008-05, Vol.128 (5), p.1182-1191
Hauptverfasser:	Guttman-Yassky, Emma, Vugmeyster, Yulia, Lowes, Michelle A., Chamian, Francesca, Kikuchi, Toyoko, Kagen, Mark, Gilleaudeau, Patricia, Lee, Edmund, Hunte, Brisdell, Howell, Kathy, Dummer, Wolfgang, Bodary, Sarah C., Krueger, James G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anergy Animal models Antibodies, Monoclonal - administration & dosage Biological and medical sciences CD11 antigen CD11a antigen CD11a Antigen - immunology CD2 antigen CD2 Antigens - metabolism CD28 Antigens - metabolism CD3 antigen CD3 Complex - metabolism CD4 Antigens - metabolism CD8 Antigens - metabolism Cell activation Clinical trials Data processing Dermatology Down-Regulation - drug effects Down-Regulation - immunology Drugs Female Humans Integrin alpha4beta1 - metabolism Integrins intercellular adhesion molecule 1 Interleukin 2 Interleukin-2 - pharmacology Internet LFA-1 antigen Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocytes T Male Medical sciences Middle Aged Monoclonal antibodies Psoriasis Psoriasis - drug therapy Psoriasis - immunology Psoriasis. Parapsoriasis. Lichen Receptors, Antigen, T-Cell - metabolism Skin diseases Surface markers T-cell receptor T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism
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