Identifying the Minimal Copper- and Zinc-binding Site Sequence in Amyloid-β Peptides

With a combination of complementary experimental techniques, namely sedimentation assay, Fourier transform infrared spectroscopy, and x-ray absorption spectroscopy, we are able to determine the atomic structure around the metal-binding site in samples where amyloid-β (Aβ) peptides are complexed with...

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Veröffentlicht in:	The Journal of biological chemistry 2008-04, Vol.283 (16), p.10784-10792
Hauptverfasser:	Minicozzi, Velia, Stellato, Francesco, Comai, Massimiliano, Serra, Mauro Dalla, Potrich, Cristina, Meyer-Klaucke, Wolfram, Morante, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid beta-Peptides - chemistry Binding Sites Copper - chemistry Histidine - chemistry Humans Metals - chemistry Models, Biological Molecular Conformation Molecular Sequence Data Peptides - chemistry Protein Binding Spectrometry, X-Ray Emission Spectroscopy, Fourier Transform Infrared Zinc - chemistry
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