Nuclear Transport: Target for Therapy
Drugs directed at plasma membrane receptors target environment–cell interactions and are the mainstay of clinical pharmacology. Decoding mechanisms that govern intracellular signaling has recently opened new therapeutic avenues for interventions at cytosol–organellar interfaces. The nuclear envelope...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2007-06, Vol.81 (6), p.880-886 |
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| container_title | Clinical pharmacology and therapeutics |
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| creator | Faustino, R S Nelson, T J Terzic, A Perez‐Terzic, C |
| description | Drugs directed at plasma membrane receptors target environment–cell interactions and are the mainstay of clinical pharmacology. Decoding mechanisms that govern intracellular signaling has recently opened new therapeutic avenues for interventions at cytosol–organellar interfaces. The nuclear envelope and nuclear transport machinery have emerged central in the discovery and development of experimental therapeutics capable of modulating cellular genetic programs. Insight into nucleocytoplasmic exchange has unmasked promising anticancer, antiviral, and anti‐inflammatory strategies.
Clinical Pharmacology & Therapeutics (2007) 81, 880–886. doi:10.1038/sj.clpt.6100141; published online 18 April 2007 |
| doi_str_mv | 10.1038/sj.clpt.6100141 |
| format | Article |
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Clinical Pharmacology & Therapeutics (2007) 81, 880–886. doi:10.1038/sj.clpt.6100141; published online 18 April 2007</description><subject>Active Transport, Cell Nucleus</subject><subject>Anti-HIV Agents - metabolism</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - metabolism</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleus - metabolism</subject><subject>Cytosol - metabolism</subject><subject>Genetic Therapy</subject><subject>Humans</subject><subject>Immunosuppressive Agents - metabolism</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Medical sciences</subject><subject>Nuclear Pore - metabolism</subject><subject>Organelles - metabolism</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Signal Transduction</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faustino, R S</creatorcontrib><creatorcontrib>Nelson, T J</creatorcontrib><creatorcontrib>Terzic, A</creatorcontrib><creatorcontrib>Perez‐Terzic, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faustino, R S</au><au>Nelson, T J</au><au>Terzic, A</au><au>Perez‐Terzic, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuclear Transport: Target for Therapy</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clin Pharmacol Ther</addtitle><date>2007-06</date><risdate>2007</risdate><volume>81</volume><issue>6</issue><spage>880</spage><epage>886</epage><pages>880-886</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><coden>CLPTAT</coden><abstract>Drugs directed at plasma membrane receptors target environment–cell interactions and are the mainstay of clinical pharmacology. Decoding mechanisms that govern intracellular signaling has recently opened new therapeutic avenues for interventions at cytosol–organellar interfaces. The nuclear envelope and nuclear transport machinery have emerged central in the discovery and development of experimental therapeutics capable of modulating cellular genetic programs. Insight into nucleocytoplasmic exchange has unmasked promising anticancer, antiviral, and anti‐inflammatory strategies.
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| ispartof | Clinical pharmacology and therapeutics, 2007-06, Vol.81 (6), p.880-886 |
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| language | eng |
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| subjects | Active Transport, Cell Nucleus Anti-HIV Agents - metabolism Anti-HIV Agents - pharmacology Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biological and medical sciences Cell Nucleus - metabolism Cytosol - metabolism Genetic Therapy Humans Immunosuppressive Agents - metabolism Immunosuppressive Agents - pharmacology Medical sciences Nuclear Pore - metabolism Organelles - metabolism Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism |
| title | Nuclear Transport: Target for Therapy |
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