Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas
Background: The aim was to assess the clinical relevance of the World Health Organization and tumour node metastasis (TNM) classifications in patients with pancreatic neuroendocrine tumours (pNETs). Methods: Prospectively collected data from 118 consecutive patients with a pNET receiving surgical in...
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| Veröffentlicht in: | British journal of surgery 2008-05, Vol.95 (5), p.627-635 |
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| container_title | British journal of surgery |
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| creator | Fischer, L. Kleeff, J. Esposito, I. Hinz, U. Zimmermann, A. Friess, H. Büchler, M. W. |
| description | Background:
The aim was to assess the clinical relevance of the World Health Organization and tumour node metastasis (TNM) classifications in patients with pancreatic neuroendocrine tumours (pNETs).
Methods:
Prospectively collected data from 118 consecutive patients with a pNET receiving surgical intervention were analysed.
Results:
Forty‐one patients had well differentiated neuroendocrine tumours, 64 had well differentiated neuroendocrine carcinomas and 13 had poorly differentiated neuroendocrine carcinomas. Five‐year survival rates were 95, 44 and 0 per cent respectively (P < 0·001). There was no difference in survival after R0 and R1/R2 resections in patients with neuroendocrine carcinomas (P = 0·905). In those with well differentiated neuroendocrine carcinomas, any resection and having a clinically non‐functional tumour significantly increased survival (P = 0·003 and P = 0·037 respectively). The TNM stage was I in 37 patients, II in 15 patients, III in 32 patients and IV in 34 patients. There were significant differences in 5‐year survival between stage I and II (88 and 85 per cent respectively) and stage III and IV (31 and 42 per cent respectively) (P = 0·010).
Conclusion:
Both classifications accurately reflect the clinical outcome of patients with pNET. The resection status may not be critical for long‐term survival in patients with pNET. Copyright © 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Resection status not critical |
| doi_str_mv | 10.1002/bjs.6051 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70505316</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70505316</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3881-46a12087d4eb545bc6ee3ccfa934e73ee3c7fa4310a842581b8148fe19908a783</originalsourceid><addsrcrecordid>eNpF0cFu1DAQBmALgei2IPEEyBd6S_HEduw9QkQLpWoPgMrNcrwT6pLYi-1s6duTqEt7Go3m00gzPyFvgJ0AY_X77jafNEzCM7IC3siqhkY_JyvGmKqA1_yAHOZ8yxhwJuuX5AA0Zw3IekViO_jgnR1onIqLI1IbNnSI4VdVMI00T2nnd_PYBwqgqYsho5uK3yHd2uIxlEzvfLmhAacUMWyiSz4gLdMYp5Rp7Gm5WWxwCW1-RV70dsj4el-PyI_TT9_bz9XF1dmX9sNF5bjWUInGQs202gjspJCdaxC5c71dc4GKL43qreDArBa11NBpELpHWK-ZtkrzI3L8sHeb4p8JczGjzw6HwQaMUzaKSSY5NDN8u4dTN-LGbJMfbbo3_180g3d7YPP8pz7Nl_j86GpWKwVCzK56cHd-wPunPcwsEZk5IrNEZD6ef1vqk_e54N9Hb9Nv0yiupLm-PDM_2_b8qzgV5pr_A0z8kn0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70505316</pqid></control><display><type>article</type><title>Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Fischer, L. ; Kleeff, J. ; Esposito, I. ; Hinz, U. ; Zimmermann, A. ; Friess, H. ; Büchler, M. W.</creator><creatorcontrib>Fischer, L. ; Kleeff, J. ; Esposito, I. ; Hinz, U. ; Zimmermann, A. ; Friess, H. ; Büchler, M. W.</creatorcontrib><description>Background:
The aim was to assess the clinical relevance of the World Health Organization and tumour node metastasis (TNM) classifications in patients with pancreatic neuroendocrine tumours (pNETs).
Methods:
Prospectively collected data from 118 consecutive patients with a pNET receiving surgical intervention were analysed.
Results:
Forty‐one patients had well differentiated neuroendocrine tumours, 64 had well differentiated neuroendocrine carcinomas and 13 had poorly differentiated neuroendocrine carcinomas. Five‐year survival rates were 95, 44 and 0 per cent respectively (P < 0·001). There was no difference in survival after R0 and R1/R2 resections in patients with neuroendocrine carcinomas (P = 0·905). In those with well differentiated neuroendocrine carcinomas, any resection and having a clinically non‐functional tumour significantly increased survival (P = 0·003 and P = 0·037 respectively). The TNM stage was I in 37 patients, II in 15 patients, III in 32 patients and IV in 34 patients. There were significant differences in 5‐year survival between stage I and II (88 and 85 per cent respectively) and stage III and IV (31 and 42 per cent respectively) (P = 0·010).
Conclusion:
Both classifications accurately reflect the clinical outcome of patients with pNET. The resection status may not be critical for long‐term survival in patients with pNET. Copyright © 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Resection status not critical</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.6051</identifier><identifier>PMID: 18306152</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Epidemiologic Methods ; Female ; General aspects ; Humans ; Length of Stay ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Neuroendocrine Tumors - classification ; Neuroendocrine Tumors - mortality ; Neuroendocrine Tumors - surgery ; Pancreatectomy - mortality ; Pancreatectomy - statistics & numerical data ; Pancreatic Neoplasms - classification ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - surgery ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Reoperation - statistics & numerical data ; Treatment Outcome</subject><ispartof>British journal of surgery, 2008-05, Vol.95 (5), p.627-635</ispartof><rights>Copyright © 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><rights>2008 INIST-CNRS</rights><rights>2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-46a12087d4eb545bc6ee3ccfa934e73ee3c7fa4310a842581b8148fe19908a783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.6051$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.6051$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20277144$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18306152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fischer, L.</creatorcontrib><creatorcontrib>Kleeff, J.</creatorcontrib><creatorcontrib>Esposito, I.</creatorcontrib><creatorcontrib>Hinz, U.</creatorcontrib><creatorcontrib>Zimmermann, A.</creatorcontrib><creatorcontrib>Friess, H.</creatorcontrib><creatorcontrib>Büchler, M. W.</creatorcontrib><title>Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background:
The aim was to assess the clinical relevance of the World Health Organization and tumour node metastasis (TNM) classifications in patients with pancreatic neuroendocrine tumours (pNETs).
Methods:
Prospectively collected data from 118 consecutive patients with a pNET receiving surgical intervention were analysed.
Results:
Forty‐one patients had well differentiated neuroendocrine tumours, 64 had well differentiated neuroendocrine carcinomas and 13 had poorly differentiated neuroendocrine carcinomas. Five‐year survival rates were 95, 44 and 0 per cent respectively (P < 0·001). There was no difference in survival after R0 and R1/R2 resections in patients with neuroendocrine carcinomas (P = 0·905). In those with well differentiated neuroendocrine carcinomas, any resection and having a clinically non‐functional tumour significantly increased survival (P = 0·003 and P = 0·037 respectively). The TNM stage was I in 37 patients, II in 15 patients, III in 32 patients and IV in 34 patients. There were significant differences in 5‐year survival between stage I and II (88 and 85 per cent respectively) and stage III and IV (31 and 42 per cent respectively) (P = 0·010).
Conclusion:
Both classifications accurately reflect the clinical outcome of patients with pNET. The resection status may not be critical for long‐term survival in patients with pNET. Copyright © 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Resection status not critical</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuroendocrine Tumors - classification</subject><subject>Neuroendocrine Tumors - mortality</subject><subject>Neuroendocrine Tumors - surgery</subject><subject>Pancreatectomy - mortality</subject><subject>Pancreatectomy - statistics & numerical data</subject><subject>Pancreatic Neoplasms - classification</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - mortality</subject><subject>Reoperation - statistics & numerical data</subject><subject>Treatment Outcome</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0cFu1DAQBmALgei2IPEEyBd6S_HEduw9QkQLpWoPgMrNcrwT6pLYi-1s6duTqEt7Go3m00gzPyFvgJ0AY_X77jafNEzCM7IC3siqhkY_JyvGmKqA1_yAHOZ8yxhwJuuX5AA0Zw3IekViO_jgnR1onIqLI1IbNnSI4VdVMI00T2nnd_PYBwqgqYsho5uK3yHd2uIxlEzvfLmhAacUMWyiSz4gLdMYp5Rp7Gm5WWxwCW1-RV70dsj4el-PyI_TT9_bz9XF1dmX9sNF5bjWUInGQs202gjspJCdaxC5c71dc4GKL43qreDArBa11NBpELpHWK-ZtkrzI3L8sHeb4p8JczGjzw6HwQaMUzaKSSY5NDN8u4dTN-LGbJMfbbo3_180g3d7YPP8pz7Nl_j86GpWKwVCzK56cHd-wPunPcwsEZk5IrNEZD6ef1vqk_e54N9Hb9Nv0yiupLm-PDM_2_b8qzgV5pr_A0z8kn0</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Fischer, L.</creator><creator>Kleeff, J.</creator><creator>Esposito, I.</creator><creator>Hinz, U.</creator><creator>Zimmermann, A.</creator><creator>Friess, H.</creator><creator>Büchler, M. W.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas</title><author>Fischer, L. ; Kleeff, J. ; Esposito, I. ; Hinz, U. ; Zimmermann, A. ; Friess, H. ; Büchler, M. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-46a12087d4eb545bc6ee3ccfa934e73ee3c7fa4310a842581b8148fe19908a783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuroendocrine Tumors - classification</topic><topic>Neuroendocrine Tumors - mortality</topic><topic>Neuroendocrine Tumors - surgery</topic><topic>Pancreatectomy - mortality</topic><topic>Pancreatectomy - statistics & numerical data</topic><topic>Pancreatic Neoplasms - classification</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - mortality</topic><topic>Reoperation - statistics & numerical data</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fischer, L.</creatorcontrib><creatorcontrib>Kleeff, J.</creatorcontrib><creatorcontrib>Esposito, I.</creatorcontrib><creatorcontrib>Hinz, U.</creatorcontrib><creatorcontrib>Zimmermann, A.</creatorcontrib><creatorcontrib>Friess, H.</creatorcontrib><creatorcontrib>Büchler, M. W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fischer, L.</au><au>Kleeff, J.</au><au>Esposito, I.</au><au>Hinz, U.</au><au>Zimmermann, A.</au><au>Friess, H.</au><au>Büchler, M. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2008-05</date><risdate>2008</risdate><volume>95</volume><issue>5</issue><spage>627</spage><epage>635</epage><pages>627-635</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background:
The aim was to assess the clinical relevance of the World Health Organization and tumour node metastasis (TNM) classifications in patients with pancreatic neuroendocrine tumours (pNETs).
Methods:
Prospectively collected data from 118 consecutive patients with a pNET receiving surgical intervention were analysed.
Results:
Forty‐one patients had well differentiated neuroendocrine tumours, 64 had well differentiated neuroendocrine carcinomas and 13 had poorly differentiated neuroendocrine carcinomas. Five‐year survival rates were 95, 44 and 0 per cent respectively (P < 0·001). There was no difference in survival after R0 and R1/R2 resections in patients with neuroendocrine carcinomas (P = 0·905). In those with well differentiated neuroendocrine carcinomas, any resection and having a clinically non‐functional tumour significantly increased survival (P = 0·003 and P = 0·037 respectively). The TNM stage was I in 37 patients, II in 15 patients, III in 32 patients and IV in 34 patients. There were significant differences in 5‐year survival between stage I and II (88 and 85 per cent respectively) and stage III and IV (31 and 42 per cent respectively) (P = 0·010).
Conclusion:
Both classifications accurately reflect the clinical outcome of patients with pNET. The resection status may not be critical for long‐term survival in patients with pNET. Copyright © 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Resection status not critical</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18306152</pmid><doi>10.1002/bjs.6051</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of surgery, 2008-05, Vol.95 (5), p.627-635 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aged Biological and medical sciences Epidemiologic Methods Female General aspects Humans Length of Stay Liver Neoplasms - mortality Liver Neoplasms - secondary Lymphatic Metastasis Male Medical sciences Middle Aged Neuroendocrine Tumors - classification Neuroendocrine Tumors - mortality Neuroendocrine Tumors - surgery Pancreatectomy - mortality Pancreatectomy - statistics & numerical data Pancreatic Neoplasms - classification Pancreatic Neoplasms - mortality Pancreatic Neoplasms - surgery Postoperative Complications - etiology Postoperative Complications - mortality Reoperation - statistics & numerical data Treatment Outcome |
| title | Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas |
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