Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted considerable attention as a novel anticancer agent. However, its efficiency may be diminished by occurring resistance in cancer cells. The mechanisms of TRAIL resistance in melanoma are still unsolved. Here we show for the...

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Veröffentlicht in:	Oncogene 2007-05, Vol.26 (23), p.3364-3377
Hauptverfasser:	Kurbanov, B M, Fecker, L F, Geilen, C C, Sterry, W, Eberle, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins - metabolism Caspases, Initiator - genetics Caspases, Initiator - metabolism Cell Line, Tumor Down-Regulation - drug effects Humans Melanoma - metabolism NF-kappa B - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism RNA, Small Interfering - genetics Sensitivity and Specificity TNF-Related Apoptosis-Inducing Ligand - pharmacology Up-Regulation - drug effects
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