Cytokine-secreting herpes viral mutants effectively treat tumor in a murine metastatic colorectal liver model by oncolytic and T-cell-dependent mechanisms

In this model of hepatic micrometastases, the antitumor efficacy and role of the T-cell and natural killer (NK) cell populations were studied for oncolytic herpes simplex virus type-1 (HSV-1) viral mutants containing the granulocyte-monocyte colony stimulating factor (GM-CSF (NV1034)) or interluken-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer gene therapy 2007-06, Vol.14 (6), p.590-597
Hauptverfasser:	DeRubertis, B G, Stiles, B M, Bhargava, A, Gusani, N J, Hezel, M, D'Angelica, M, Fong, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antitumor activity Biomedical and Life Sciences Biomedicine Care and treatment Cell Culture Techniques Colony-stimulating factor Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Cytokines Cytokines - genetics Cytokines - immunology Cytokines - secretion Cytotoxicity Effector cells Gene Expression Gene Therapy Genetic aspects Genetic Therapy Genetic Vectors - genetics Granulocyte-macrophage colony-stimulating factor Health aspects Herpes simplex Herpes simplex virus Herpes simplex virus 1 Herpes viruses Interleukin 12 Leukocytes (granulocytic) Liver Liver cancer Lymphocytes T Metastases Metastasis Methods Mice Models, Animal Monocytes Multiplicity of infection Mutants Natural killer cells Oncolysis Oncolytic Virotherapy original-article Population studies Replication Risk factors Simplexvirus - genetics T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes, Regulatory - immunology Tumors Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!