Number of children and coronary heart disease risk factors in men and women from a British birth cohort
Objective To examine the association between number of children and coronary heart disease (CHD) risk factors in women and men. Design Prospective cohort study. Setting Britain. Sample A total of 2977 individuals (51% women) from the Medical Research Council National Survey of Health and Develop...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2007-06, Vol.114 (6), p.721-730 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Hardy, R Lawlor, DA Black, S Wadsworth, MEJ Kuh, D |
| description | Objective To examine the association between number of children and coronary heart disease (CHD) risk factors in women and men.
Design Prospective cohort study.
Setting Britain.
Sample A total of 2977 individuals (51% women) from the Medical Research Council National Survey of Health and Development, a birth cohort study of individuals born in Britain in 1946 and followed up regularly throughout life.
Main outcome measures Blood pressure, body mass index (BMI), waist to hip ratio (WHR), total, high‐density lipoprotein and low‐density lipoprotein cholesterol and triglyceride levels, and glycated haemoglobin (HbA1C) measured at age of 53 years.
Results Number of children showed no consistent relationship with CHD risk factors at age 53 years in either men or women, and no obvious and consistent sex differences were observed. Mean BMI (95% CI) increased with increasing numbers of children (P = 0.01) in women from 27.4 kg/m2 (26.6–28.2) in those with one child to 28.6 kg/m2 (27.6–29.6) in those with four or more children. WHR and type II diabetes in women and HbA1C in men were the only other risk factors exhibiting a linearly increasing trend with increasing number of children. These associations were largely explained by adjustment for behavioural and lifestyle variables.
Conclusion Our findings suggest that any association between number of children and CHD risk factors is a result of lifestyle and behaviours associated with family life rather than being as result of the biological impact of pregnancy in women. |
| doi_str_mv | 10.1111/j.1471-0528.2007.01324.x |
| format | Article |
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Design Prospective cohort study.
Setting Britain.
Sample A total of 2977 individuals (51% women) from the Medical Research Council National Survey of Health and Development, a birth cohort study of individuals born in Britain in 1946 and followed up regularly throughout life.
Main outcome measures Blood pressure, body mass index (BMI), waist to hip ratio (WHR), total, high‐density lipoprotein and low‐density lipoprotein cholesterol and triglyceride levels, and glycated haemoglobin (HbA1C) measured at age of 53 years.
Results Number of children showed no consistent relationship with CHD risk factors at age 53 years in either men or women, and no obvious and consistent sex differences were observed. Mean BMI (95% CI) increased with increasing numbers of children (P = 0.01) in women from 27.4 kg/m2 (26.6–28.2) in those with one child to 28.6 kg/m2 (27.6–29.6) in those with four or more children. WHR and type II diabetes in women and HbA1C in men were the only other risk factors exhibiting a linearly increasing trend with increasing number of children. These associations were largely explained by adjustment for behavioural and lifestyle variables.
Conclusion Our findings suggest that any association between number of children and CHD risk factors is a result of lifestyle and behaviours associated with family life rather than being as result of the biological impact of pregnancy in women.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2007.01324.x</identifier><identifier>PMID: 17516964</identifier><identifier>CODEN: BIOGFQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Body Mass Index ; Cardiology. Vascular system ; CHD risk factors ; Children & youth ; Cohort Studies ; Coronary Disease - epidemiology ; Coronary Disease - etiology ; Coronary heart disease ; epidemiology ; Families & family life ; Family Characteristics ; Female ; Gynecology. Andrology. Obstetrics ; Health behavior ; Heart ; Humans ; Male ; Medical sciences ; Men ; Middle Aged ; Parity ; Pregnancy ; Prospective Studies ; Risk Factors ; Socioeconomic Factors ; United Kingdom - epidemiology ; Women</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2007-06, Vol.114 (6), p.721-730</ispartof><rights>RCOG 2007 BJOG An International Journal of Obstetrics and Gynaecology</rights><rights>2007 INIST-CNRS</rights><rights>2007 The Authors Journal compilation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4904-f4b7a6b6e827139b102f8ae23fa4bc44d96c2ad2c32571c678863eab088020083</citedby><cites>FETCH-LOGICAL-c4904-f4b7a6b6e827139b102f8ae23fa4bc44d96c2ad2c32571c678863eab088020083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2007.01324.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2007.01324.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18772179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17516964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hardy, R</creatorcontrib><creatorcontrib>Lawlor, DA</creatorcontrib><creatorcontrib>Black, S</creatorcontrib><creatorcontrib>Wadsworth, MEJ</creatorcontrib><creatorcontrib>Kuh, D</creatorcontrib><title>Number of children and coronary heart disease risk factors in men and women from a British birth cohort</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective To examine the association between number of children and coronary heart disease (CHD) risk factors in women and men.
Design Prospective cohort study.
Setting Britain.
Sample A total of 2977 individuals (51% women) from the Medical Research Council National Survey of Health and Development, a birth cohort study of individuals born in Britain in 1946 and followed up regularly throughout life.
Main outcome measures Blood pressure, body mass index (BMI), waist to hip ratio (WHR), total, high‐density lipoprotein and low‐density lipoprotein cholesterol and triglyceride levels, and glycated haemoglobin (HbA1C) measured at age of 53 years.
Results Number of children showed no consistent relationship with CHD risk factors at age 53 years in either men or women, and no obvious and consistent sex differences were observed. Mean BMI (95% CI) increased with increasing numbers of children (P = 0.01) in women from 27.4 kg/m2 (26.6–28.2) in those with one child to 28.6 kg/m2 (27.6–29.6) in those with four or more children. WHR and type II diabetes in women and HbA1C in men were the only other risk factors exhibiting a linearly increasing trend with increasing number of children. These associations were largely explained by adjustment for behavioural and lifestyle variables.
Conclusion Our findings suggest that any association between number of children and CHD risk factors is a result of lifestyle and behaviours associated with family life rather than being as result of the biological impact of pregnancy in women.</description><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>CHD risk factors</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - etiology</subject><subject>Coronary heart disease</subject><subject>epidemiology</subject><subject>Families & family life</subject><subject>Family Characteristics</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health behavior</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Socioeconomic Factors</subject><subject>United Kingdom - epidemiology</subject><subject>Women</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1jAQhS0EoqXwCshCgl2Cb7GdBQtacVVFN7C2HMcm_kniMk7U9u1x-kdUYoU3PtJ8czQ6ByFMSU3Le3uoqVC0Ig3TNSNE1YRyJurbR-j07-DxvSYV4UyfoGc5HwihkhH-FJ1Q1VDZSnGKfn5bp84DTgG7IY49-BnbuccuQZot3OHBW1hwH7O32WOI-RcO1i0JMo4znnb8Jm0qQJqwxecQl5gH3EVYhuI0JFieoyfBjtm_2P8z9OPjh-8Xn6vLq09fLt5fVk60RFRBdMrKTnrNFOVtRwkL2nrGgxWdE6JvpWO2Z46zRlEnldaSe9sRrUkJQvMz9Oboew3p9-rzYqaYnR9HO_u0ZqNIQ4TkG_jqH_CQVpjLbYaxRtJGSlUgfYQcpJzBB3MNcSqxGErM1oQ5mC1wswVutibMfRPmtqy-3P3XbvL9w-IefQFe74DNzo4B7OxifuC0UoyqtnDvjtxNHP3dfx9gzr9ebYr_AfPVot4</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Hardy, R</creator><creator>Lawlor, DA</creator><creator>Black, S</creator><creator>Wadsworth, MEJ</creator><creator>Kuh, D</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200706</creationdate><title>Number of children and coronary heart disease risk factors in men and women from a British birth cohort</title><author>Hardy, R ; Lawlor, DA ; Black, S ; Wadsworth, MEJ ; Kuh, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4904-f4b7a6b6e827139b102f8ae23fa4bc44d96c2ad2c32571c678863eab088020083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>CHD risk factors</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - etiology</topic><topic>Coronary heart disease</topic><topic>epidemiology</topic><topic>Families & family life</topic><topic>Family Characteristics</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health behavior</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Socioeconomic Factors</topic><topic>United Kingdom - epidemiology</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hardy, R</creatorcontrib><creatorcontrib>Lawlor, DA</creatorcontrib><creatorcontrib>Black, S</creatorcontrib><creatorcontrib>Wadsworth, MEJ</creatorcontrib><creatorcontrib>Kuh, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hardy, R</au><au>Lawlor, DA</au><au>Black, S</au><au>Wadsworth, MEJ</au><au>Kuh, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Number of children and coronary heart disease risk factors in men and women from a British birth cohort</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2007-06</date><risdate>2007</risdate><volume>114</volume><issue>6</issue><spage>721</spage><epage>730</epage><pages>721-730</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><coden>BIOGFQ</coden><abstract>Objective To examine the association between number of children and coronary heart disease (CHD) risk factors in women and men.
Design Prospective cohort study.
Setting Britain.
Sample A total of 2977 individuals (51% women) from the Medical Research Council National Survey of Health and Development, a birth cohort study of individuals born in Britain in 1946 and followed up regularly throughout life.
Main outcome measures Blood pressure, body mass index (BMI), waist to hip ratio (WHR), total, high‐density lipoprotein and low‐density lipoprotein cholesterol and triglyceride levels, and glycated haemoglobin (HbA1C) measured at age of 53 years.
Results Number of children showed no consistent relationship with CHD risk factors at age 53 years in either men or women, and no obvious and consistent sex differences were observed. Mean BMI (95% CI) increased with increasing numbers of children (P = 0.01) in women from 27.4 kg/m2 (26.6–28.2) in those with one child to 28.6 kg/m2 (27.6–29.6) in those with four or more children. WHR and type II diabetes in women and HbA1C in men were the only other risk factors exhibiting a linearly increasing trend with increasing number of children. These associations were largely explained by adjustment for behavioural and lifestyle variables.
Conclusion Our findings suggest that any association between number of children and CHD risk factors is a result of lifestyle and behaviours associated with family life rather than being as result of the biological impact of pregnancy in women.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17516964</pmid><doi>10.1111/j.1471-0528.2007.01324.x</doi><tpages>10</tpages></addata></record> |
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| subjects | Biological and medical sciences Body Mass Index Cardiology. Vascular system CHD risk factors Children & youth Cohort Studies Coronary Disease - epidemiology Coronary Disease - etiology Coronary heart disease epidemiology Families & family life Family Characteristics Female Gynecology. Andrology. Obstetrics Health behavior Heart Humans Male Medical sciences Men Middle Aged Parity Pregnancy Prospective Studies Risk Factors Socioeconomic Factors United Kingdom - epidemiology Women |
| title | Number of children and coronary heart disease risk factors in men and women from a British birth cohort |
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