Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin–haptoglobin complex
This study examined the relationship between steroid treatment and CD163-mediated downstream pathways linked to inflammatory resolution. Twelve patients referred for congenital heart disease surgery were divided into two groups based on the severity of intravascular hemolysis during cardiopulmonary...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2007-06, Vol.358 (2), p.506-512 |
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| creator | Yamazaki, Haruyuki Ohta, Kunio Tsukiji, Hidenori Toma, Tomoko Hashida, Yoko Ishizaki, Akiko Saito, Takekatsu Arai, Sadahiko Koizumi, Shoichi Yachie, Akihiro |
| description | This study examined the relationship between steroid treatment and CD163-mediated downstream pathways linked to inflammatory resolution. Twelve patients referred for congenital heart disease surgery were divided into two groups based on the severity of intravascular hemolysis during cardiopulmonary bypass surgery. Patients with severe intravascular hemolysis were administered haptoglobin during the procedure. Flow cytometry indicated a peak in monocyte CD163 expression on post-operative day 1 in both groups. Enhanced and prolonged heme oxygenase-1 (HO-1) mRNA expression levels were observed in patients who received haptoglobin. Binding of hemoglobin–haptoglobin complex (Hb/Hp) to CD163 resulted in significant induction of HO-1 by peripheral blood mononuclear cells after exposure to dexamethasone prior to culture. This effect was significantly inhibited by anti-CD163 antibody. Our results demonstrated up-regulation of CD163 expression on the monocyte surface by steroid treatment. Steroid treatment was suggested to facilitate CD163-mediated endocytosis of hemoglobin to monocytes/macrophages and thereby induce acceleration of HO-1 synthesis. |
| doi_str_mv | 10.1016/j.bbrc.2007.04.136 |
| format | Article |
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Twelve patients referred for congenital heart disease surgery were divided into two groups based on the severity of intravascular hemolysis during cardiopulmonary bypass surgery. Patients with severe intravascular hemolysis were administered haptoglobin during the procedure. Flow cytometry indicated a peak in monocyte CD163 expression on post-operative day 1 in both groups. Enhanced and prolonged heme oxygenase-1 (HO-1) mRNA expression levels were observed in patients who received haptoglobin. Binding of hemoglobin–haptoglobin complex (Hb/Hp) to CD163 resulted in significant induction of HO-1 by peripheral blood mononuclear cells after exposure to dexamethasone prior to culture. This effect was significantly inhibited by anti-CD163 antibody. Our results demonstrated up-regulation of CD163 expression on the monocyte surface by steroid treatment. Steroid treatment was suggested to facilitate CD163-mediated endocytosis of hemoglobin to monocytes/macrophages and thereby induce acceleration of HO-1 synthesis.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2007.04.136</identifier><identifier>PMID: 17490617</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenal Cortex Hormones - administration & dosage ; Antigens, CD - metabolism ; Antigens, Differentiation, Myelomonocytic - metabolism ; Cardiopulmonary bypass ; CD163 ; Cells, Cultured ; Congenital heart disease ; Enzyme Activation - drug effects ; Haptoglobins - metabolism ; Heart Defects, Congenital - drug therapy ; Heart Defects, Congenital - metabolism ; Heme oxygenase-1 ; Heme Oxygenase-1 - metabolism ; Hemoglobins - metabolism ; Hemoglobin–haptoglobin complex ; Humans ; Monocytes - drug effects ; Monocytes - metabolism ; Receptors, Cell Surface - metabolism ; Steroid ; Up-Regulation - drug effects</subject><ispartof>Biochemical and biophysical research communications, 2007-06, Vol.358 (2), p.506-512</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-8f5444c6d700855ec7d90b9a92dd8c8620bf5ec9491aecf72eb0f6576de1926b3</citedby><cites>FETCH-LOGICAL-c451t-8f5444c6d700855ec7d90b9a92dd8c8620bf5ec9491aecf72eb0f6576de1926b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X07008856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17490617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamazaki, Haruyuki</creatorcontrib><creatorcontrib>Ohta, Kunio</creatorcontrib><creatorcontrib>Tsukiji, Hidenori</creatorcontrib><creatorcontrib>Toma, Tomoko</creatorcontrib><creatorcontrib>Hashida, Yoko</creatorcontrib><creatorcontrib>Ishizaki, Akiko</creatorcontrib><creatorcontrib>Saito, Takekatsu</creatorcontrib><creatorcontrib>Arai, Sadahiko</creatorcontrib><creatorcontrib>Koizumi, Shoichi</creatorcontrib><creatorcontrib>Yachie, Akihiro</creatorcontrib><title>Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin–haptoglobin complex</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>This study examined the relationship between steroid treatment and CD163-mediated downstream pathways linked to inflammatory resolution. Twelve patients referred for congenital heart disease surgery were divided into two groups based on the severity of intravascular hemolysis during cardiopulmonary bypass surgery. Patients with severe intravascular hemolysis were administered haptoglobin during the procedure. Flow cytometry indicated a peak in monocyte CD163 expression on post-operative day 1 in both groups. Enhanced and prolonged heme oxygenase-1 (HO-1) mRNA expression levels were observed in patients who received haptoglobin. Binding of hemoglobin–haptoglobin complex (Hb/Hp) to CD163 resulted in significant induction of HO-1 by peripheral blood mononuclear cells after exposure to dexamethasone prior to culture. This effect was significantly inhibited by anti-CD163 antibody. Our results demonstrated up-regulation of CD163 expression on the monocyte surface by steroid treatment. Steroid treatment was suggested to facilitate CD163-mediated endocytosis of hemoglobin to monocytes/macrophages and thereby induce acceleration of HO-1 synthesis.</description><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Antigens, CD - metabolism</subject><subject>Antigens, Differentiation, Myelomonocytic - metabolism</subject><subject>Cardiopulmonary bypass</subject><subject>CD163</subject><subject>Cells, Cultured</subject><subject>Congenital heart disease</subject><subject>Enzyme Activation - drug effects</subject><subject>Haptoglobins - metabolism</subject><subject>Heart Defects, Congenital - drug therapy</subject><subject>Heart Defects, Congenital - metabolism</subject><subject>Heme oxygenase-1</subject><subject>Heme Oxygenase-1 - metabolism</subject><subject>Hemoglobins - metabolism</subject><subject>Hemoglobin–haptoglobin complex</subject><subject>Humans</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - metabolism</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Steroid</subject><subject>Up-Regulation - drug effects</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2O1DAQRiMEYpqBC7BAXrFLKKcdO5HYoNYwII3EBiR2lmNX0m6SONjOaLLjDnMsbsFJcKubnxWsLFW9erK-L8ueUygoUP7qULSt10UJIApgBd3yB9mGQgN5SYE9zDYAwPOyoZ8vsichHAAoZbx5nF1QwRrgVGyy7zvno9UuRPTOGoLTXk0aA9njiMTdrT1OKmBOyeydWXS0biLtSrT1ehlUtFNPRjc5vcZ0lBbLnHvsf62SxfWDa-1Egla3OPXoiUeNc3SeqMkQNc6D7dYjHPf4e5ePaKyKaJIwqi_pK91fsh_f7vcqYWe1dkmCd0-zR50aAj47v5fZp7dXH3fv8psP1-93b25yzSoa87qrGGOaGwFQVxVqYRpoG9WUxtS65iW0XZo2rKEKdSdKbKHjleAGaVPydnuZvTx5UyRfFwxRjjZoHAY1oVuCFFDBlm_r_4IlCCoEKxNYnkDtXQgeOzl7Oyq_Sgry2LU8yGPX8ti1BCZT1-noxdm-tCmtPyfnchPw-gRgCuPWopdBW0ztGptijtI4-y__T79-wxo</recordid><startdate>20070629</startdate><enddate>20070629</enddate><creator>Yamazaki, Haruyuki</creator><creator>Ohta, Kunio</creator><creator>Tsukiji, Hidenori</creator><creator>Toma, Tomoko</creator><creator>Hashida, Yoko</creator><creator>Ishizaki, Akiko</creator><creator>Saito, Takekatsu</creator><creator>Arai, Sadahiko</creator><creator>Koizumi, Shoichi</creator><creator>Yachie, Akihiro</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070629</creationdate><title>Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin–haptoglobin complex</title><author>Yamazaki, Haruyuki ; Ohta, Kunio ; Tsukiji, Hidenori ; Toma, Tomoko ; Hashida, Yoko ; Ishizaki, Akiko ; Saito, Takekatsu ; Arai, Sadahiko ; Koizumi, Shoichi ; Yachie, Akihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-8f5444c6d700855ec7d90b9a92dd8c8620bf5ec9491aecf72eb0f6576de1926b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Antigens, CD - metabolism</topic><topic>Antigens, Differentiation, Myelomonocytic - metabolism</topic><topic>Cardiopulmonary bypass</topic><topic>CD163</topic><topic>Cells, Cultured</topic><topic>Congenital heart disease</topic><topic>Enzyme Activation - drug effects</topic><topic>Haptoglobins - metabolism</topic><topic>Heart Defects, Congenital - drug therapy</topic><topic>Heart Defects, Congenital - metabolism</topic><topic>Heme oxygenase-1</topic><topic>Heme Oxygenase-1 - metabolism</topic><topic>Hemoglobins - metabolism</topic><topic>Hemoglobin–haptoglobin complex</topic><topic>Humans</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - metabolism</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Steroid</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamazaki, Haruyuki</creatorcontrib><creatorcontrib>Ohta, Kunio</creatorcontrib><creatorcontrib>Tsukiji, Hidenori</creatorcontrib><creatorcontrib>Toma, Tomoko</creatorcontrib><creatorcontrib>Hashida, Yoko</creatorcontrib><creatorcontrib>Ishizaki, Akiko</creatorcontrib><creatorcontrib>Saito, Takekatsu</creatorcontrib><creatorcontrib>Arai, Sadahiko</creatorcontrib><creatorcontrib>Koizumi, Shoichi</creatorcontrib><creatorcontrib>Yachie, Akihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamazaki, Haruyuki</au><au>Ohta, Kunio</au><au>Tsukiji, Hidenori</au><au>Toma, Tomoko</au><au>Hashida, Yoko</au><au>Ishizaki, Akiko</au><au>Saito, Takekatsu</au><au>Arai, Sadahiko</au><au>Koizumi, Shoichi</au><au>Yachie, Akihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin–haptoglobin complex</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2007-06-29</date><risdate>2007</risdate><volume>358</volume><issue>2</issue><spage>506</spage><epage>512</epage><pages>506-512</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>This study examined the relationship between steroid treatment and CD163-mediated downstream pathways linked to inflammatory resolution. Twelve patients referred for congenital heart disease surgery were divided into two groups based on the severity of intravascular hemolysis during cardiopulmonary bypass surgery. Patients with severe intravascular hemolysis were administered haptoglobin during the procedure. Flow cytometry indicated a peak in monocyte CD163 expression on post-operative day 1 in both groups. Enhanced and prolonged heme oxygenase-1 (HO-1) mRNA expression levels were observed in patients who received haptoglobin. Binding of hemoglobin–haptoglobin complex (Hb/Hp) to CD163 resulted in significant induction of HO-1 by peripheral blood mononuclear cells after exposure to dexamethasone prior to culture. This effect was significantly inhibited by anti-CD163 antibody. Our results demonstrated up-regulation of CD163 expression on the monocyte surface by steroid treatment. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenal Cortex Hormones - administration & dosage Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Cardiopulmonary bypass CD163 Cells, Cultured Congenital heart disease Enzyme Activation - drug effects Haptoglobins - metabolism Heart Defects, Congenital - drug therapy Heart Defects, Congenital - metabolism Heme oxygenase-1 Heme Oxygenase-1 - metabolism Hemoglobins - metabolism Hemoglobin–haptoglobin complex Humans Monocytes - drug effects Monocytes - metabolism Receptors, Cell Surface - metabolism Steroid Up-Regulation - drug effects |
| title | Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin–haptoglobin complex |
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