A new method of monitoring osteomyelitis
Abstract Chronic infections of bone such as osteomyelitis are frequent events, especially in immunocompromised or diabetic patients, and costly on a national level. Incorrect treatment or delayed diagnosis may lead to loss of the affected extremity or mandible. The aim of this study was to assess th...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2007-06, Vol.36 (6), p.527-532 |
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| container_title | International journal of oral and maxillofacial surgery |
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| creator | Springer, I.N.G Wiltfang, J Dunsche, A Lier, G.C Bartsch, M Warnke, P.H Barth, E.L Terheyden, H Russo, Paul A.J Czech, N Acil, Y |
| description | Abstract Chronic infections of bone such as osteomyelitis are frequent events, especially in immunocompromised or diabetic patients, and costly on a national level. Incorrect treatment or delayed diagnosis may lead to loss of the affected extremity or mandible. The aim of this study was to assess the possible value of urinary lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) concentrations in the monitoring of mandibular osteomyelitis. Patients were assigned to the following groups: group 1 ( n = 85), control; group 2a ( n = 38), patients with active disease; group 2b ( n = 25), patients of group 2a 6 months after successful treatment; group 2c ( n = 7), patients of group 2a with ongoing osteomyelitis 6 months after treatment. The range and upper limit of normal values (HPmax and LPmax ) were determined in group 1. Levels of LP and HP were measured by high-performance liquid chromatography and fluorescence detection. There was a significant decrease (mean 45.43% for HP and 32.12% for LP) in samples of group 2b compared to 2a ( P < 0.001 for HP and LP). There was a significant increase in HP values in samples from group 2c compared to 2a ( P = 0.018). The urinary concentrations of HP and LP appear to act as a marker of disease activity, with a decrease reflecting treatment success and an increase or stable values indicating persistent disease. An inexpensive tool (US$5 per analysis) for the monitoring of osteomyelitis is described. |
| doi_str_mv | 10.1016/j.ijom.2007.01.001 |
| format | Article |
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Incorrect treatment or delayed diagnosis may lead to loss of the affected extremity or mandible. The aim of this study was to assess the possible value of urinary lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) concentrations in the monitoring of mandibular osteomyelitis. Patients were assigned to the following groups: group 1 ( n = 85), control; group 2a ( n = 38), patients with active disease; group 2b ( n = 25), patients of group 2a 6 months after successful treatment; group 2c ( n = 7), patients of group 2a with ongoing osteomyelitis 6 months after treatment. The range and upper limit of normal values (HPmax and LPmax ) were determined in group 1. Levels of LP and HP were measured by high-performance liquid chromatography and fluorescence detection. There was a significant decrease (mean 45.43% for HP and 32.12% for LP) in samples of group 2b compared to 2a ( P < 0.001 for HP and LP). There was a significant increase in HP values in samples from group 2c compared to 2a ( P = 0.018). The urinary concentrations of HP and LP appear to act as a marker of disease activity, with a decrease reflecting treatment success and an increase or stable values indicating persistent disease. An inexpensive tool (US$5 per analysis) for the monitoring of osteomyelitis is described.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2007.01.001</identifier><identifier>PMID: 17418531</identifier><identifier>CODEN: IJOSE9</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amino Acids - urine ; Bacterial arthritis and osteitis ; Bacterial diseases ; Biological and medical sciences ; Biomarkers - urine ; bone ; Chromatography - methods ; Dentistry ; Epidemiologic Methods ; Female ; Fluorescence ; Human bacterial diseases ; Humans ; hydroxylysylpyridinoline ; Infectious diseases ; lysylpyridinoline ; Male ; Mandibular Diseases - diagnosis ; Mandibular Diseases - surgery ; Mandibular Diseases - urine ; marker ; Medical sciences ; Middle Aged ; monitoring ; osteomyelitis ; Osteomyelitis - diagnosis ; Osteomyelitis - surgery ; Osteomyelitis - urine ; Otorhinolaryngology. Stomatology ; Recurrence ; Sex Factors ; Surgery</subject><ispartof>International journal of oral and maxillofacial surgery, 2007-06, Vol.36 (6), p.527-532</ispartof><rights>International Association of Oral and Maxillofacial Surgeons</rights><rights>2007 International Association of Oral and Maxillofacial Surgeons</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-7fb83ef97ea7f647f06e2755a740e68a6d6d202c03869083660946015b639d493</citedby><cites>FETCH-LOGICAL-c439t-7fb83ef97ea7f647f06e2755a740e68a6d6d202c03869083660946015b639d493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0901502707000276$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18804449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17418531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Springer, I.N.G</creatorcontrib><creatorcontrib>Wiltfang, J</creatorcontrib><creatorcontrib>Dunsche, A</creatorcontrib><creatorcontrib>Lier, G.C</creatorcontrib><creatorcontrib>Bartsch, M</creatorcontrib><creatorcontrib>Warnke, P.H</creatorcontrib><creatorcontrib>Barth, E.L</creatorcontrib><creatorcontrib>Terheyden, H</creatorcontrib><creatorcontrib>Russo, Paul A.J</creatorcontrib><creatorcontrib>Czech, N</creatorcontrib><creatorcontrib>Acil, Y</creatorcontrib><title>A new method of monitoring osteomyelitis</title><title>International journal of oral and maxillofacial surgery</title><addtitle>Int J Oral Maxillofac Surg</addtitle><description>Abstract Chronic infections of bone such as osteomyelitis are frequent events, especially in immunocompromised or diabetic patients, and costly on a national level. Incorrect treatment or delayed diagnosis may lead to loss of the affected extremity or mandible. The aim of this study was to assess the possible value of urinary lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) concentrations in the monitoring of mandibular osteomyelitis. Patients were assigned to the following groups: group 1 ( n = 85), control; group 2a ( n = 38), patients with active disease; group 2b ( n = 25), patients of group 2a 6 months after successful treatment; group 2c ( n = 7), patients of group 2a with ongoing osteomyelitis 6 months after treatment. The range and upper limit of normal values (HPmax and LPmax ) were determined in group 1. Levels of LP and HP were measured by high-performance liquid chromatography and fluorescence detection. There was a significant decrease (mean 45.43% for HP and 32.12% for LP) in samples of group 2b compared to 2a ( P < 0.001 for HP and LP). There was a significant increase in HP values in samples from group 2c compared to 2a ( P = 0.018). The urinary concentrations of HP and LP appear to act as a marker of disease activity, with a decrease reflecting treatment success and an increase or stable values indicating persistent disease. An inexpensive tool (US$5 per analysis) for the monitoring of osteomyelitis is described.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino Acids - urine</subject><subject>Bacterial arthritis and osteitis</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - urine</subject><subject>bone</subject><subject>Chromatography - methods</subject><subject>Dentistry</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>hydroxylysylpyridinoline</subject><subject>Infectious diseases</subject><subject>lysylpyridinoline</subject><subject>Male</subject><subject>Mandibular Diseases - diagnosis</subject><subject>Mandibular Diseases - surgery</subject><subject>Mandibular Diseases - urine</subject><subject>marker</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>monitoring</subject><subject>osteomyelitis</subject><subject>Osteomyelitis - diagnosis</subject><subject>Osteomyelitis - surgery</subject><subject>Osteomyelitis - urine</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Recurrence</subject><subject>Sex Factors</subject><subject>Surgery</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFO3DAQhi3UqrtAX4ADyqWIS8LYTuxYqiohBC3SSj1QzpbXmYBDEoOdLdq3r8OuhNQDJ1--f2b8_YScUCgoUHHRFa7zQ8EAZAG0AKAHZEm5UjkAg09kCQpoXgGTC3IYYwcAitfyC1lQWdK64nRJzi-zEV-zAadH32S-zQY_uskHNz5kPk7ohy32bnLxmHxuTR_x6_49Ivc313-ufuWr3z9vry5XuS25mnLZrmuOrZJoZCtK2YJAJqvKyBJQ1EY0omHALPBaKKi5EKBKAbRaC66aUvEjcrab-xz8ywbjpAcXLfa9GdFvopZQAedSJJDtQBt8jAFb_RzcYMJWU9CzH93p2Y-e_WigOvlJodP99M16wOY9sheSgG97wERr-jaY0br4ztU1lOXbmd93HCYXfx0GHa3D0WLjAtpJN959fMeP_-K2d6NLG59wi7HzmzAmy5rqyDTou7nJuUiQqUSWfv8PffqVmg</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Springer, I.N.G</creator><creator>Wiltfang, J</creator><creator>Dunsche, A</creator><creator>Lier, G.C</creator><creator>Bartsch, M</creator><creator>Warnke, P.H</creator><creator>Barth, E.L</creator><creator>Terheyden, H</creator><creator>Russo, Paul A.J</creator><creator>Czech, N</creator><creator>Acil, Y</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>A new method of monitoring osteomyelitis</title><author>Springer, I.N.G ; Wiltfang, J ; Dunsche, A ; Lier, G.C ; Bartsch, M ; Warnke, P.H ; Barth, E.L ; Terheyden, H ; Russo, Paul A.J ; Czech, N ; Acil, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-7fb83ef97ea7f647f06e2755a740e68a6d6d202c03869083660946015b639d493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino Acids - urine</topic><topic>Bacterial arthritis and osteitis</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - urine</topic><topic>bone</topic><topic>Chromatography - methods</topic><topic>Dentistry</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>hydroxylysylpyridinoline</topic><topic>Infectious diseases</topic><topic>lysylpyridinoline</topic><topic>Male</topic><topic>Mandibular Diseases - diagnosis</topic><topic>Mandibular Diseases - surgery</topic><topic>Mandibular Diseases - urine</topic><topic>marker</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>monitoring</topic><topic>osteomyelitis</topic><topic>Osteomyelitis - diagnosis</topic><topic>Osteomyelitis - surgery</topic><topic>Osteomyelitis - urine</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Recurrence</topic><topic>Sex Factors</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Springer, I.N.G</creatorcontrib><creatorcontrib>Wiltfang, J</creatorcontrib><creatorcontrib>Dunsche, A</creatorcontrib><creatorcontrib>Lier, G.C</creatorcontrib><creatorcontrib>Bartsch, M</creatorcontrib><creatorcontrib>Warnke, P.H</creatorcontrib><creatorcontrib>Barth, E.L</creatorcontrib><creatorcontrib>Terheyden, H</creatorcontrib><creatorcontrib>Russo, Paul A.J</creatorcontrib><creatorcontrib>Czech, N</creatorcontrib><creatorcontrib>Acil, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Springer, I.N.G</au><au>Wiltfang, J</au><au>Dunsche, A</au><au>Lier, G.C</au><au>Bartsch, M</au><au>Warnke, P.H</au><au>Barth, E.L</au><au>Terheyden, H</au><au>Russo, Paul A.J</au><au>Czech, N</au><au>Acil, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new method of monitoring osteomyelitis</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>36</volume><issue>6</issue><spage>527</spage><epage>532</epage><pages>527-532</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><coden>IJOSE9</coden><abstract>Abstract Chronic infections of bone such as osteomyelitis are frequent events, especially in immunocompromised or diabetic patients, and costly on a national level. Incorrect treatment or delayed diagnosis may lead to loss of the affected extremity or mandible. The aim of this study was to assess the possible value of urinary lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) concentrations in the monitoring of mandibular osteomyelitis. Patients were assigned to the following groups: group 1 ( n = 85), control; group 2a ( n = 38), patients with active disease; group 2b ( n = 25), patients of group 2a 6 months after successful treatment; group 2c ( n = 7), patients of group 2a with ongoing osteomyelitis 6 months after treatment. The range and upper limit of normal values (HPmax and LPmax ) were determined in group 1. Levels of LP and HP were measured by high-performance liquid chromatography and fluorescence detection. There was a significant decrease (mean 45.43% for HP and 32.12% for LP) in samples of group 2b compared to 2a ( P < 0.001 for HP and LP). There was a significant increase in HP values in samples from group 2c compared to 2a ( P = 0.018). The urinary concentrations of HP and LP appear to act as a marker of disease activity, with a decrease reflecting treatment success and an increase or stable values indicating persistent disease. An inexpensive tool (US$5 per analysis) for the monitoring of osteomyelitis is described.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>17418531</pmid><doi>10.1016/j.ijom.2007.01.001</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Amino Acids - urine Bacterial arthritis and osteitis Bacterial diseases Biological and medical sciences Biomarkers - urine bone Chromatography - methods Dentistry Epidemiologic Methods Female Fluorescence Human bacterial diseases Humans hydroxylysylpyridinoline Infectious diseases lysylpyridinoline Male Mandibular Diseases - diagnosis Mandibular Diseases - surgery Mandibular Diseases - urine marker Medical sciences Middle Aged monitoring osteomyelitis Osteomyelitis - diagnosis Osteomyelitis - surgery Osteomyelitis - urine Otorhinolaryngology. Stomatology Recurrence Sex Factors Surgery |
| title | A new method of monitoring osteomyelitis |
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