Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: Patterns of linkage disequilibrium and disease/marker association

The ε 4 allele of APOE confers a two- to fourfold increased risk for late-onset Alzheimer’s disease (LOAD), but LOAD pathology does not all fit neatly around APOE. It is conceivable that genetic variation proximate to APOE contributes to LOAD risk. Therefore, we investigated the degree of linkage di...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2007-06, Vol.89 (6), p.655-665
Hauptverfasser:	Yu, Chang-En, Seltman, Howard, Peskind, Elaine R., Galloway, Nichole, Zhou, Peter X., Rosenthal, Elisabeth, Wijsman, Ellen M., Tsuang, Debby W., Devlin, Bernie, Schellenberg, Gerard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Alleles Alzheimer disease Alzheimer Disease - genetics Apolipoprotein E Apolipoprotein E4 - genetics Apolipoproteins E - genetics Biological and medical sciences Case-Control Studies Chromosome Mapping Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases European Continental Ancestry Group - genetics Female Fundamental and applied biological sciences. Psychology Genes. Genome Genetic association Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Haplotypes Humans Linkage Disequilibrium Male Medical sciences Membrane Transport Proteins - genetics Molecular and cellular biology Molecular genetics Molecular haplotyping Neurology Polymorphism, Single Nucleotide Risk Factors Selection
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