Clues from Alopecia Areata on the Role of Neuropeptides in the Initiation of Autoimmunity

A fascinating question regarding the pathogenesis of alopecia areata is the potential linkage with the brain. Siebenharr et al. demonstrate that substance P fibers are increased in early lesions, and that substance P treatment induces catagen follicles along with activated CD8+ T cells. Potentially,...

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