Clues from Alopecia Areata on the Role of Neuropeptides in the Initiation of Autoimmunity
A fascinating question regarding the pathogenesis of alopecia areata is the potential linkage with the brain. Siebenharr et al. demonstrate that substance P fibers are increased in early lesions, and that substance P treatment induces catagen follicles along with activated CD8+ T cells. Potentially,...
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| Veröffentlicht in: | Journal of investigative dermatology 2007-06, Vol.127 (6), p.1289-1291 |
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| container_title | Journal of investigative dermatology |
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| creator | Kalish, Richard S. |
| description | A fascinating question regarding the pathogenesis of alopecia areata is the potential linkage with the brain. Siebenharr et al. demonstrate that substance P fibers are increased in early lesions, and that substance P treatment induces catagen follicles along with activated CD8+ T cells. Potentially, neuropeptides serve as the initial insult resulting in loss of tolerance and autoimmune disease. |
| doi_str_mv | 10.1038/sj.jid.5700655 |
| format | Article |
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| identifier | ISSN: 0022-202X |
| ispartof | Journal of investigative dermatology, 2007-06, Vol.127 (6), p.1289-1291 |
| issn | 0022-202X 1523-1747 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Alopecia Alopecia Areata - etiology Alopecia Areata - immunology Animals Autoimmunity - physiology Brain CD8 antigen CD8-Positive T-Lymphocytes - immunology Dermatology Fibers Follicles Humans Immunological tolerance Lymphocytes T Neuropeptides Substance P Substance P - immunology |
| title | Clues from Alopecia Areata on the Role of Neuropeptides in the Initiation of Autoimmunity |
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