Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans
Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles. BAL fluid was obtained from 12 children with BO who had a histor...
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| Veröffentlicht in: | Chest 2007-05, Vol.131 (5), p.1454-1460 |
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| creator | Koh, Young Yull Jung, Da Eun Koh, Ji Yeon Kim, Jung Yeon Yoo, Young Kim, Chang Keun |
| description | Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles.
BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8.
BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean ± SD, 418.6 ± 286.0 pg/mL) compared to the control group (92.8 ± 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens.
These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection. |
| doi_str_mv | 10.1378/chest.06-0188 |
| format | Article |
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BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8.
BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean ± SD, 418.6 ± 286.0 pg/mL) compared to the control group (92.8 ± 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens.
These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.06-0188</identifier><identifier>PMID: 17494793</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biopsy ; bronchiolitis obliterans ; Bronchiolitis Obliterans - etiology ; Bronchiolitis Obliterans - pathology ; Bronchoalveolar Lavage Fluid - chemistry ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoscopy ; Cardiology. Vascular system ; Case-Control Studies ; CD3 Complex - metabolism ; CD8 ; CD8 Antigens - metabolism ; Cell Count ; Child, Preschool ; Chronic obstructive pulmonary disease, asthma ; Female ; Human viral diseases ; Humans ; Infant ; Infectious diseases ; interleukin-8 ; Interleukin-8 - analysis ; Lung - diagnostic imaging ; Lung - immunology ; Lung - pathology ; Male ; measles ; Measles - complications ; Measles - pathology ; Medical sciences ; neutrophils ; Neutrophils - pathology ; Pneumology ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology ; Tomography, X-Ray Computed ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>Chest, 2007-05, Vol.131 (5), p.1454-1460</ispartof><rights>2007 The American College of Chest Physicians</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-ec63bd133d14e76385fefee801b5e1cb4af70b59aee5f72e8bce2750e20e20b53</citedby><cites>FETCH-LOGICAL-c410t-ec63bd133d14e76385fefee801b5e1cb4af70b59aee5f72e8bce2750e20e20b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18748282$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17494793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koh, Young Yull</creatorcontrib><creatorcontrib>Jung, Da Eun</creatorcontrib><creatorcontrib>Koh, Ji Yeon</creatorcontrib><creatorcontrib>Kim, Jung Yeon</creatorcontrib><creatorcontrib>Yoo, Young</creatorcontrib><creatorcontrib>Kim, Chang Keun</creatorcontrib><title>Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans</title><title>Chest</title><addtitle>Chest</addtitle><description>Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles.
BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8.
BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean ± SD, 418.6 ± 286.0 pg/mL) compared to the control group (92.8 ± 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens.
These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>bronchiolitis obliterans</subject><subject>Bronchiolitis Obliterans - etiology</subject><subject>Bronchiolitis Obliterans - pathology</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchoscopy</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>CD3 Complex - metabolism</subject><subject>CD8</subject><subject>CD8 Antigens - metabolism</subject><subject>Cell Count</subject><subject>Child, Preschool</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Female</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>interleukin-8</subject><subject>Interleukin-8 - analysis</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - immunology</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>measles</subject><subject>Measles - complications</subject><subject>Measles - pathology</subject><subject>Medical sciences</subject><subject>neutrophils</subject><subject>Neutrophils - pathology</subject><subject>Pneumology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><subject>Tomography, X-Ray Computed</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFvFCEUh4nRtOvao1czF71N5Q3MAEfdVNtkTS828UYY5o1LZaHCzJr-92U7m_RkQvIg-X4P3gch74FeAhPys91hni5pV1OQ8hVZgWJQs5az12RFKTQ161RzTt7mfE_LGVR3Rs5BcMWFYivy62uKwe6i8QeM3qRqg97PZeOmx8qEoboJEyaP8x8Xallt8YA-Vy5UP9Bkj7la8i56N7lc3falYjIhvyNvRuMzXpzqmtx9u_q5ua63t99vNl-2teVApxptx_oBGBuAo-iYbEccESWFvkWwPTejoH2rDGI7igZlb7ERLcXmuPqWrcmnpe9Din_n4kLvXbZlCBMwzlkLypWSShSwXkCbYs4JR_2Q3N6kRw1UH1XqZ5WadvqosvAfTo3nfo_DC31yV4CPJ8Bka_xYprYuv3BScNnIpnB04Xbu9-6fS6jz3nhf2rLlyvs4p2A8MNCtBl7-bk3EEimy8eAw6WwdBotDidtJD9H959VPnEei_g</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Koh, Young Yull</creator><creator>Jung, Da Eun</creator><creator>Koh, Ji Yeon</creator><creator>Kim, Jung Yeon</creator><creator>Yoo, Young</creator><creator>Kim, Chang Keun</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans</title><author>Koh, Young Yull ; Jung, Da Eun ; Koh, Ji Yeon ; Kim, Jung Yeon ; Yoo, Young ; Kim, Chang Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-ec63bd133d14e76385fefee801b5e1cb4af70b59aee5f72e8bce2750e20e20b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>bronchiolitis obliterans</topic><topic>Bronchiolitis Obliterans - etiology</topic><topic>Bronchiolitis Obliterans - pathology</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Bronchoscopy</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>CD3 Complex - metabolism</topic><topic>CD8</topic><topic>CD8 Antigens - metabolism</topic><topic>Cell Count</topic><topic>Child, Preschool</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Female</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>interleukin-8</topic><topic>Interleukin-8 - analysis</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - immunology</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>measles</topic><topic>Measles - complications</topic><topic>Measles - pathology</topic><topic>Medical sciences</topic><topic>neutrophils</topic><topic>Neutrophils - pathology</topic><topic>Pneumology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><topic>Tomography, X-Ray Computed</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koh, Young Yull</creatorcontrib><creatorcontrib>Jung, Da Eun</creatorcontrib><creatorcontrib>Koh, Ji Yeon</creatorcontrib><creatorcontrib>Kim, Jung Yeon</creatorcontrib><creatorcontrib>Yoo, Young</creatorcontrib><creatorcontrib>Kim, Chang Keun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koh, Young Yull</au><au>Jung, Da Eun</au><au>Koh, Ji Yeon</au><au>Kim, Jung Yeon</au><au>Yoo, Young</au><au>Kim, Chang Keun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>131</volume><issue>5</issue><spage>1454</spage><epage>1460</epage><pages>1454-1460</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles.
BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8.
BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean ± SD, 418.6 ± 286.0 pg/mL) compared to the control group (92.8 ± 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens.
These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>17494793</pmid><doi>10.1378/chest.06-0188</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Biopsy bronchiolitis obliterans Bronchiolitis Obliterans - etiology Bronchiolitis Obliterans - pathology Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoscopy Cardiology. Vascular system Case-Control Studies CD3 Complex - metabolism CD8 CD8 Antigens - metabolism Cell Count Child, Preschool Chronic obstructive pulmonary disease, asthma Female Human viral diseases Humans Infant Infectious diseases interleukin-8 Interleukin-8 - analysis Lung - diagnostic imaging Lung - immunology Lung - pathology Male measles Measles - complications Measles - pathology Medical sciences neutrophils Neutrophils - pathology Pneumology T-Lymphocytes - immunology T-Lymphocytes - pathology Tomography, X-Ray Computed Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | Bronchoalveolar Cellularity and Interleukin-8 Levels in Measles Bronchiolitis Obliterans |
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