M129V variation in the prion protein gene and psychotic disorders: Relationship to neuropsychological and psychopathological measures

Abstract The methionine/valine polymorphism at position 129 in the prion protein gene, PRNP M129V, is a known risk factor for Creutzfeldt-Jakob disease (CJD). Psychiatric manifestations including psychosis are common in the early phase of CJD and it has therefore been hypothesized that the prion pro...

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