HPTLC Determination of Rabeprazole and Domperidone in Capsules and its Validation
This paper describes a validated high-performance thin-layer chromatography (HPTLC) method for simultaneous estimation of rabeprazole (RA) and domperidone (DO) in pure powder and in capsule formulations. An HPTLC method separation is achieved on an aluminum sheet of silica gel 60F254 using ethyl ace...
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| Veröffentlicht in: | Journal of chromatographic science 2008-04, Vol.46 (4), p.304-307 |
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| container_title | Journal of chromatographic science |
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| creator | Patel, Bhavesh H. Suhagia, Bhanubhai N. Patel, Madhabhai M. Patel, Jignesh R. |
| description | This paper describes a validated high-performance thin-layer chromatography (HPTLC) method for simultaneous estimation of rabeprazole (RA) and domperidone (DO) in pure powder and in capsule formulations. An HPTLC method separation is achieved on an aluminum sheet of silica gel 60F254 using ethyl acetate-methanol-benzene-acetonitrile (30:20:30:20 v/v) as mobile phase. Quantitation is achieved with UV detection at 287 nm over a concentration range of 400-1200 ng/spot and 600-1800 ng/spot with mean recovery of 99.82 ± 0.74 and 99.43 ± 0.68 for RA and DO, respectively, in the HPTLC method. This method is simple, precise, and sensitive, and it is applicable for the simultaneous determination of RA and DO in pure powder and in capsule formulation. |
| doi_str_mv | 10.1093/chromsci/46.4.304 |
| format | Article |
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An HPTLC method separation is achieved on an aluminum sheet of silica gel 60F254 using ethyl acetate-methanol-benzene-acetonitrile (30:20:30:20 v/v) as mobile phase. Quantitation is achieved with UV detection at 287 nm over a concentration range of 400-1200 ng/spot and 600-1800 ng/spot with mean recovery of 99.82 ± 0.74 and 99.43 ± 0.68 for RA and DO, respectively, in the HPTLC method. This method is simple, precise, and sensitive, and it is applicable for the simultaneous determination of RA and DO in pure powder and in capsule formulation.</description><identifier>ISSN: 0021-9665</identifier><identifier>EISSN: 1945-239X</identifier><identifier>DOI: 10.1093/chromsci/46.4.304</identifier><identifier>PMID: 18402720</identifier><identifier>CODEN: JCHSBZ</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>2-Pyridinylmethylsulfinylbenzimidazoles - isolation & purification ; Analysis ; Biological and medical sciences ; Capsules - chemistry ; Chromatography, High Pressure Liquid - methods ; Chromatography, Thin Layer - methods ; Domperidone - isolation & purification ; General pharmacology ; Medical sciences ; Pharmacology. Drug treatments ; Rabeprazole ; Reproducibility of Results ; Uncertainty</subject><ispartof>Journal of chromatographic science, 2008-04, Vol.46 (4), p.304-307</ispartof><rights>2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-784334b48f18e11354521d9f26ca9e96627ec85af73ee1f0d9aa6c0da6b13d013</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20193414$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18402720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Bhavesh H.</creatorcontrib><creatorcontrib>Suhagia, Bhanubhai N.</creatorcontrib><creatorcontrib>Patel, Madhabhai M.</creatorcontrib><creatorcontrib>Patel, Jignesh R.</creatorcontrib><title>HPTLC Determination of Rabeprazole and Domperidone in Capsules and its Validation</title><title>Journal of chromatographic science</title><addtitle>Journal of Chromatographic Science</addtitle><addtitle>Journal of Chromatographic Science</addtitle><description>This paper describes a validated high-performance thin-layer chromatography (HPTLC) method for simultaneous estimation of rabeprazole (RA) and domperidone (DO) in pure powder and in capsule formulations. An HPTLC method separation is achieved on an aluminum sheet of silica gel 60F254 using ethyl acetate-methanol-benzene-acetonitrile (30:20:30:20 v/v) as mobile phase. Quantitation is achieved with UV detection at 287 nm over a concentration range of 400-1200 ng/spot and 600-1800 ng/spot with mean recovery of 99.82 ± 0.74 and 99.43 ± 0.68 for RA and DO, respectively, in the HPTLC method. This method is simple, precise, and sensitive, and it is applicable for the simultaneous determination of RA and DO in pure powder and in capsule formulation.</description><subject>2-Pyridinylmethylsulfinylbenzimidazoles - isolation & purification</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Capsules - chemistry</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Thin Layer - methods</subject><subject>Domperidone - isolation & purification</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabeprazole</subject><subject>Reproducibility of Results</subject><subject>Uncertainty</subject><issn>0021-9665</issn><issn>1945-239X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhq0K1C6lP4BLlQucyNYTO3F8RNuPRWz56ocqLtasM1ENSRzsRAJ-Pdnutlw5WSM_zzujl7FXwOfAtTix98G30boTWczlXHC5x2agZZ5mQt89YzPOM0h1UeQH7EWM3zcjlPk-O4BS8kxlfMa-LD9frxbJKQ0UWtfh4HyX-Dr5imvqA_7xDSXYVcmpb3sKrvIdJa5LFtjHsaH48OeGmNxi46oH-yV7XmMT6Wj3HrKb87PrxTJdfbp4v3i3Sq3kckhVKYWQa1nWUBKAyGWeQaXrrLCoaTo6U2TLHGsliKDmlUYsLK-wWIOoOIhD9mab2wf_c6Q4mNZFS02DHfkxGsWl1pKrCYQtaIOPMVBt-uBaDL8NcLPp0Tz2aGRhpJl6nJzjXfi4bqn6Z-yKm4DXOwCjxaYO2FkXn7iMgxYSNkFvt5wf-__am25xFwf69SRg-GEKJVRulnffzAdxlcNHdWEuxV8aPJrA</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Patel, Bhavesh H.</creator><creator>Suhagia, Bhanubhai N.</creator><creator>Patel, Madhabhai M.</creator><creator>Patel, Jignesh R.</creator><general>Oxford University Press</general><general>Preston Publications</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>HPTLC Determination of Rabeprazole and Domperidone in Capsules and its Validation</title><author>Patel, Bhavesh H. ; Suhagia, Bhanubhai N. ; Patel, Madhabhai M. ; Patel, Jignesh R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-784334b48f18e11354521d9f26ca9e96627ec85af73ee1f0d9aa6c0da6b13d013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>2-Pyridinylmethylsulfinylbenzimidazoles - isolation & purification</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Capsules - chemistry</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, Thin Layer - methods</topic><topic>Domperidone - isolation & purification</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabeprazole</topic><topic>Reproducibility of Results</topic><topic>Uncertainty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Bhavesh H.</creatorcontrib><creatorcontrib>Suhagia, Bhanubhai N.</creatorcontrib><creatorcontrib>Patel, Madhabhai M.</creatorcontrib><creatorcontrib>Patel, Jignesh R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatographic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Bhavesh H.</au><au>Suhagia, Bhanubhai N.</au><au>Patel, Madhabhai M.</au><au>Patel, Jignesh R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HPTLC Determination of Rabeprazole and Domperidone in Capsules and its Validation</atitle><jtitle>Journal of chromatographic science</jtitle><stitle>Journal of Chromatographic Science</stitle><addtitle>Journal of Chromatographic Science</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>46</volume><issue>4</issue><spage>304</spage><epage>307</epage><pages>304-307</pages><issn>0021-9665</issn><eissn>1945-239X</eissn><coden>JCHSBZ</coden><abstract>This paper describes a validated high-performance thin-layer chromatography (HPTLC) method for simultaneous estimation of rabeprazole (RA) and domperidone (DO) in pure powder and in capsule formulations. An HPTLC method separation is achieved on an aluminum sheet of silica gel 60F254 using ethyl acetate-methanol-benzene-acetonitrile (30:20:30:20 v/v) as mobile phase. Quantitation is achieved with UV detection at 287 nm over a concentration range of 400-1200 ng/spot and 600-1800 ng/spot with mean recovery of 99.82 ± 0.74 and 99.43 ± 0.68 for RA and DO, respectively, in the HPTLC method. This method is simple, precise, and sensitive, and it is applicable for the simultaneous determination of RA and DO in pure powder and in capsule formulation.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>18402720</pmid><doi>10.1093/chromsci/46.4.304</doi><tpages>4</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | 2-Pyridinylmethylsulfinylbenzimidazoles - isolation & purification Analysis Biological and medical sciences Capsules - chemistry Chromatography, High Pressure Liquid - methods Chromatography, Thin Layer - methods Domperidone - isolation & purification General pharmacology Medical sciences Pharmacology. Drug treatments Rabeprazole Reproducibility of Results Uncertainty |
| title | HPTLC Determination of Rabeprazole and Domperidone in Capsules and its Validation |
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