Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants

In this large cross-sectional study, we investigated the relationship between phytoestrogen exposure and circulating sex hormones and sex hormone-binding globulin (SHBG) levels in 1988 healthy postmenopausal women and their interactions with polymorphisms in genes involved in estrogen signaling. Pla...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2007-05, Vol.16 (5), p.1009-1016
Hauptverfasser:	LOW, Yen-Ling, DUNNING, Alison M, BINGHAML, Sheila A, DOWSETT, Mitch, FOLKERD, Elizabeth, DOODY, Deborah, TAYLOR, James, BHANIANI, Amit, LUBEN, Robert, KHAW, Kay-Tee, WAREHAM, Nick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Biological and medical sciences Biomarkers, Tumor - blood cross-sectional Cross-Sectional Studies Diet EPIC-Norfolk ESR1 ESR2 Female Fundamental and applied biological sciences. Psychology Genotype Glycine max Gonadal Steroid Hormones - blood Humans Medical sciences Middle Aged NR1I2 phytoestrogens Phytoestrogens - administration & dosage Phytoestrogens - metabolism Phytoestrogens - urine polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Postmenopause - blood Postmenopause - metabolism Pregnane X Receptor Prospective Studies Proteins Receptors, Estrogen - genetics Receptors, Steroid - genetics Sex Hormone-Binding Globulin - analysis Sex Hormone-Binding Globulin - metabolism sex hormones SHBG Tumors
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