Peroxisome Proliferator-activated Receptor γ 2 and Acyl-CoA Synthetase 5 Polymorphisms Influence Diet Response
Peroxisome proliferator-activated receptor γ (PPARγ) and its response gene, Acyl CoA synthetase 5 (ACSL5), which has an important role in fatty acid metabolism, may affect weight loss in response to caloric restriction. Therefore, we aimed to determine whether these genes were involved in the interi...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2007-05, Vol.15 (5), p.1068-1075 |
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| creator | Adamo, Kristi B Dent, Robert Langefeld, Carl D Cox, Miranda Williams, Kathryn Carrick, Kevin M Stuart, Joan S Sundseth, Scott S Harper, Mary-Ellen McPherson, Ruth Tesson, Frédérique |
| description | Peroxisome proliferator-activated receptor γ (PPARγ) and its response gene, Acyl CoA synthetase 5 (ACSL5), which has an important role in fatty acid metabolism, may affect weight loss in response to caloric restriction. Therefore, we aimed to determine whether these genes were involved in the interindividual response to dietary treatment. Genotypic/phenotypic comparisons were made between selected obese women from the quintiles losing the most (diet responsive, n = 74) and the quintiles losing the least (diet-resistant, n = 67) weight in the first 6 weeks of a 900-kcal formula diet. Two common PPARγ single nucleotide polymorphisms, Pro¹²Ala and C1431T, and eight polymorphisms across the ACSL5 gene were selected for single locus and haplotypic association analyses. The PPARγ Pro¹²Ala single nucleotide polymorphism was associated with diet resistance (odds ratio = 3.48, 95% confidence interval = 1.41 to 8.56, p = 0.03), and the rs2419621, located in the 5'untranslated region of the ACSL5 gene, displayed the strongest association with diet response (odds ratio = 3.45, 95% confidence interval = 1.61 to 7.69, p = 0.001). Skeletal muscle ACSL5 mRNA expression was significantly lower in carriers of the wildtype compared with the variant rs2419621 allele (p = 0.03). Our results suggest a link between PPARγ2 and ACSL5 genotype and diet responsiveness. |
| doi_str_mv | 10.1038/oby.2007.630 |
| format | Article |
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Therefore, we aimed to determine whether these genes were involved in the interindividual response to dietary treatment. Genotypic/phenotypic comparisons were made between selected obese women from the quintiles losing the most (diet responsive, n = 74) and the quintiles losing the least (diet-resistant, n = 67) weight in the first 6 weeks of a 900-kcal formula diet. Two common PPARγ single nucleotide polymorphisms, Pro¹²Ala and C1431T, and eight polymorphisms across the ACSL5 gene were selected for single locus and haplotypic association analyses. The PPARγ Pro¹²Ala single nucleotide polymorphism was associated with diet resistance (odds ratio = 3.48, 95% confidence interval = 1.41 to 8.56, p = 0.03), and the rs2419621, located in the 5'untranslated region of the ACSL5 gene, displayed the strongest association with diet response (odds ratio = 3.45, 95% confidence interval = 1.61 to 7.69, p = 0.001). Skeletal muscle ACSL5 mRNA expression was significantly lower in carriers of the wildtype compared with the variant rs2419621 allele (p = 0.03). Our results suggest a link between PPARγ2 and ACSL5 genotype and diet responsiveness.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1038/oby.2007.630</identifier><identifier>PMID: 17495181</identifier><language>eng</language><publisher>Oxford, UK: The North American Association for the Study of Obesity</publisher><subject>Acyl CoA synthetase ; acyl-CoA synthetase 5 ; Analysis of Variance ; Coenzyme A Ligases - genetics ; Diet ; diet response ; DNA Primers ; Exons ; genetic polymorphism ; Genetic Variation ; genotype ; haplotype ; Humans ; low calorie diet ; messenger RNA ; obese women ; obesity ; peroxisome proliferator-activated receptor gamma2 ; peroxisome proliferator‐activated receptor γ ; phenotype ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; PPAR gamma - genetics ; receptors ; RNA, Messenger - genetics ; skeletal muscle ; transcription factors ; weight control ; weight loss ; women</subject><ispartof>Obesity (Silver Spring, Md.), 2007-05, Vol.15 (5), p.1068-1075</ispartof><rights>2007 North American Association for the Study of Obesity (NAASO)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3540-ac2cbbe0a7bdef55e142dd1a9835da98989d112b2253bcd8ca34b4b5d108b0b63</citedby><cites>FETCH-LOGICAL-c3540-ac2cbbe0a7bdef55e142dd1a9835da98989d112b2253bcd8ca34b4b5d108b0b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2007.630$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2007.630$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17495181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adamo, Kristi B</creatorcontrib><creatorcontrib>Dent, Robert</creatorcontrib><creatorcontrib>Langefeld, Carl D</creatorcontrib><creatorcontrib>Cox, Miranda</creatorcontrib><creatorcontrib>Williams, Kathryn</creatorcontrib><creatorcontrib>Carrick, Kevin M</creatorcontrib><creatorcontrib>Stuart, Joan S</creatorcontrib><creatorcontrib>Sundseth, Scott S</creatorcontrib><creatorcontrib>Harper, Mary-Ellen</creatorcontrib><creatorcontrib>McPherson, Ruth</creatorcontrib><creatorcontrib>Tesson, Frédérique</creatorcontrib><title>Peroxisome Proliferator-activated Receptor γ 2 and Acyl-CoA Synthetase 5 Polymorphisms Influence Diet Response</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Peroxisome proliferator-activated receptor γ (PPARγ) and its response gene, Acyl CoA synthetase 5 (ACSL5), which has an important role in fatty acid metabolism, may affect weight loss in response to caloric restriction. Therefore, we aimed to determine whether these genes were involved in the interindividual response to dietary treatment. Genotypic/phenotypic comparisons were made between selected obese women from the quintiles losing the most (diet responsive, n = 74) and the quintiles losing the least (diet-resistant, n = 67) weight in the first 6 weeks of a 900-kcal formula diet. Two common PPARγ single nucleotide polymorphisms, Pro¹²Ala and C1431T, and eight polymorphisms across the ACSL5 gene were selected for single locus and haplotypic association analyses. The PPARγ Pro¹²Ala single nucleotide polymorphism was associated with diet resistance (odds ratio = 3.48, 95% confidence interval = 1.41 to 8.56, p = 0.03), and the rs2419621, located in the 5'untranslated region of the ACSL5 gene, displayed the strongest association with diet response (odds ratio = 3.45, 95% confidence interval = 1.61 to 7.69, p = 0.001). Skeletal muscle ACSL5 mRNA expression was significantly lower in carriers of the wildtype compared with the variant rs2419621 allele (p = 0.03). Our results suggest a link between PPARγ2 and ACSL5 genotype and diet responsiveness.</description><subject>Acyl CoA synthetase</subject><subject>acyl-CoA synthetase 5</subject><subject>Analysis of Variance</subject><subject>Coenzyme A Ligases - genetics</subject><subject>Diet</subject><subject>diet response</subject><subject>DNA Primers</subject><subject>Exons</subject><subject>genetic polymorphism</subject><subject>Genetic Variation</subject><subject>genotype</subject><subject>haplotype</subject><subject>Humans</subject><subject>low calorie diet</subject><subject>messenger RNA</subject><subject>obese women</subject><subject>obesity</subject><subject>peroxisome proliferator-activated receptor gamma2</subject><subject>peroxisome proliferator‐activated receptor γ</subject><subject>phenotype</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>PPAR gamma - genetics</subject><subject>receptors</subject><subject>RNA, Messenger - genetics</subject><subject>skeletal muscle</subject><subject>transcription factors</subject><subject>weight control</subject><subject>weight loss</subject><subject>women</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhq0K1JbCrWfwqSeyHdvxJjlul69KlbpqqURPlj8m1CiJUzsL5HfxP_hNuNoV3JClsTV65h35IeSUwYKBqM-DmRccoFosBRyQY9YIKCrRfHn2912zI_IipW8A5RIkOyRHrCobyWp2TMIGY_jpU-iRbmLofItRTyEW2k7-u57Q0Ru0OOYW_f2LcqoHR1d27op1WNHbeZgecNIJqaSb0M19iOODT32il0PbbXGwSN95nHJIGsOQ8CV53uou4av9fULuPrz_vP5UXF1_vFyvrgorZAl5O7fGIOjKOGylRFZy55huaiFdrvk4xrjhXApjXW21KE1ppGNQGzBLcULOdrljDI9bTJPqfbLYdXrAsE2qgrKpl7zO4NsdaGNIKWKrxuh7HWfFQD0JVlmwehKssuCMv97nbk2P7h-8N5oB2AE_fIfzf8PU9cV9_mweebMbaXVQ-mv0Sd3dcmAic1XFm0b8ARDjkUc</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Adamo, Kristi B</creator><creator>Dent, Robert</creator><creator>Langefeld, Carl D</creator><creator>Cox, Miranda</creator><creator>Williams, Kathryn</creator><creator>Carrick, Kevin M</creator><creator>Stuart, Joan S</creator><creator>Sundseth, Scott S</creator><creator>Harper, Mary-Ellen</creator><creator>McPherson, Ruth</creator><creator>Tesson, Frédérique</creator><general>The North American Association for the Study of Obesity</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>Peroxisome Proliferator-activated Receptor γ 2 and Acyl-CoA Synthetase 5 Polymorphisms Influence Diet Response</title><author>Adamo, Kristi B ; Dent, Robert ; Langefeld, Carl D ; Cox, Miranda ; Williams, Kathryn ; Carrick, Kevin M ; Stuart, Joan S ; Sundseth, Scott S ; Harper, Mary-Ellen ; McPherson, Ruth ; Tesson, Frédérique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3540-ac2cbbe0a7bdef55e142dd1a9835da98989d112b2253bcd8ca34b4b5d108b0b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acyl CoA synthetase</topic><topic>acyl-CoA synthetase 5</topic><topic>Analysis of Variance</topic><topic>Coenzyme A Ligases - genetics</topic><topic>Diet</topic><topic>diet response</topic><topic>DNA Primers</topic><topic>Exons</topic><topic>genetic polymorphism</topic><topic>Genetic Variation</topic><topic>genotype</topic><topic>haplotype</topic><topic>Humans</topic><topic>low calorie diet</topic><topic>messenger RNA</topic><topic>obese women</topic><topic>obesity</topic><topic>peroxisome proliferator-activated receptor gamma2</topic><topic>peroxisome proliferator‐activated receptor γ</topic><topic>phenotype</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>PPAR gamma - genetics</topic><topic>receptors</topic><topic>RNA, Messenger - genetics</topic><topic>skeletal muscle</topic><topic>transcription factors</topic><topic>weight control</topic><topic>weight loss</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adamo, Kristi B</creatorcontrib><creatorcontrib>Dent, Robert</creatorcontrib><creatorcontrib>Langefeld, Carl D</creatorcontrib><creatorcontrib>Cox, Miranda</creatorcontrib><creatorcontrib>Williams, Kathryn</creatorcontrib><creatorcontrib>Carrick, Kevin M</creatorcontrib><creatorcontrib>Stuart, Joan S</creatorcontrib><creatorcontrib>Sundseth, Scott S</creatorcontrib><creatorcontrib>Harper, Mary-Ellen</creatorcontrib><creatorcontrib>McPherson, Ruth</creatorcontrib><creatorcontrib>Tesson, Frédérique</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adamo, Kristi B</au><au>Dent, Robert</au><au>Langefeld, Carl D</au><au>Cox, Miranda</au><au>Williams, Kathryn</au><au>Carrick, Kevin M</au><au>Stuart, Joan S</au><au>Sundseth, Scott S</au><au>Harper, Mary-Ellen</au><au>McPherson, Ruth</au><au>Tesson, Frédérique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peroxisome Proliferator-activated Receptor γ 2 and Acyl-CoA Synthetase 5 Polymorphisms Influence Diet Response</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2007-05</date><risdate>2007</risdate><volume>15</volume><issue>5</issue><spage>1068</spage><epage>1075</epage><pages>1068-1075</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Peroxisome proliferator-activated receptor γ (PPARγ) and its response gene, Acyl CoA synthetase 5 (ACSL5), which has an important role in fatty acid metabolism, may affect weight loss in response to caloric restriction. Therefore, we aimed to determine whether these genes were involved in the interindividual response to dietary treatment. Genotypic/phenotypic comparisons were made between selected obese women from the quintiles losing the most (diet responsive, n = 74) and the quintiles losing the least (diet-resistant, n = 67) weight in the first 6 weeks of a 900-kcal formula diet. Two common PPARγ single nucleotide polymorphisms, Pro¹²Ala and C1431T, and eight polymorphisms across the ACSL5 gene were selected for single locus and haplotypic association analyses. The PPARγ Pro¹²Ala single nucleotide polymorphism was associated with diet resistance (odds ratio = 3.48, 95% confidence interval = 1.41 to 8.56, p = 0.03), and the rs2419621, located in the 5'untranslated region of the ACSL5 gene, displayed the strongest association with diet response (odds ratio = 3.45, 95% confidence interval = 1.61 to 7.69, p = 0.001). Skeletal muscle ACSL5 mRNA expression was significantly lower in carriers of the wildtype compared with the variant rs2419621 allele (p = 0.03). Our results suggest a link between PPARγ2 and ACSL5 genotype and diet responsiveness.</abstract><cop>Oxford, UK</cop><pub>The North American Association for the Study of Obesity</pub><pmid>17495181</pmid><doi>10.1038/oby.2007.630</doi><tpages>8</tpages></addata></record> |
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| subjects | Acyl CoA synthetase acyl-CoA synthetase 5 Analysis of Variance Coenzyme A Ligases - genetics Diet diet response DNA Primers Exons genetic polymorphism Genetic Variation genotype haplotype Humans low calorie diet messenger RNA obese women obesity peroxisome proliferator-activated receptor gamma2 peroxisome proliferator‐activated receptor γ phenotype Polymorphism, Genetic Polymorphism, Single Nucleotide PPAR gamma - genetics receptors RNA, Messenger - genetics skeletal muscle transcription factors weight control weight loss women |
| title | Peroxisome Proliferator-activated Receptor γ 2 and Acyl-CoA Synthetase 5 Polymorphisms Influence Diet Response |
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