Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters
Abstract Objective The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). Study Design In this prospective observational study, observed PA (main, right...
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| Veröffentlicht in: | Journal of pediatric surgery 2008-04, Vol.43 (4), p.606-611 |
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| creator | Ruano, Rodrigo Aubry, Marie-Cécile Barthe, Bruno Mitanchez, Delphine Dumez, Yves Benachi, Alexandra |
| description | Abstract Objective The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). Study Design In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH. Results The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls ( P < .001) and in fetuses with CDH who died ( P < .050). However, there was no significant association between PA diameters and PAH ( P ≥ .050). Conclusions The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia. |
| doi_str_mv | 10.1016/j.jpedsurg.2007.12.003 |
| format | Article |
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Study Design In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH. Results The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls ( P < .001) and in fetuses with CDH who died ( P < .050). However, there was no significant association between PA diameters and PAH ( P ≥ .050). Conclusions The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/j.jpedsurg.2007.12.003</identifier><identifier>PMID: 18405704</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Congenital diaphragmatic hernia ; Fetal lung ; Fetal malformation ; Hernia, Diaphragmatic - complications ; Hernia, Diaphragmatic - diagnosis ; Hernias, Diaphragmatic, Congenital ; Humans ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - etiology ; Pediatrics ; Predictors of mortality ; Prospective Studies ; Pulmonary arteries ; Pulmonary Artery - diagnostic imaging ; Pulmonary Artery - embryology ; Pulmonary hypoplasia ; Surgery ; Ultrasonography, Prenatal ; Weights and Measures</subject><ispartof>Journal of pediatric surgery, 2008-04, Vol.43 (4), p.606-611</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-f81a0ae9b8c4034da166b54490dc1be7c26b62d04693c385e9f1d3874598ce0a3</citedby><cites>FETCH-LOGICAL-c421t-f81a0ae9b8c4034da166b54490dc1be7c26b62d04693c385e9f1d3874598ce0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpedsurg.2007.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18405704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruano, Rodrigo</creatorcontrib><creatorcontrib>Aubry, Marie-Cécile</creatorcontrib><creatorcontrib>Barthe, Bruno</creatorcontrib><creatorcontrib>Mitanchez, Delphine</creatorcontrib><creatorcontrib>Dumez, Yves</creatorcontrib><creatorcontrib>Benachi, Alexandra</creatorcontrib><title>Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>Abstract Objective The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). Study Design In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH. Results The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls ( P < .001) and in fetuses with CDH who died ( P < .050). However, there was no significant association between PA diameters and PAH ( P ≥ .050). Conclusions The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia.</description><subject>Congenital diaphragmatic hernia</subject><subject>Fetal lung</subject><subject>Fetal malformation</subject><subject>Hernia, Diaphragmatic - complications</subject><subject>Hernia, Diaphragmatic - diagnosis</subject><subject>Hernias, Diaphragmatic, Congenital</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Pediatrics</subject><subject>Predictors of mortality</subject><subject>Prospective Studies</subject><subject>Pulmonary arteries</subject><subject>Pulmonary Artery - diagnostic imaging</subject><subject>Pulmonary Artery - embryology</subject><subject>Pulmonary hypoplasia</subject><subject>Surgery</subject><subject>Ultrasonography, Prenatal</subject><subject>Weights and Measures</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-L1TAQxYO4uNfVr7D0ybfWSZM27Ysoi_9gwYVdn0OaTO-mtklNUmG_vSn3iuCLTxPIOWdmfkPINYWKAm3fTtW0oolbOFY1gKhoXQGwZ-RAG0bLBph4Tg4AdV0y3naX5GWME2SFAPqCXNKOQyOAH4i_C2isTtYdixWDdSqpufBb0n7BwrrCRj-rhKbQ3h3R2f3bWLU-BnVcVLK6eMTgrCq2uGeMuAvWbV68U-GpUCFhLtmxYH7FV-RiVHPE1-d6Rb5_-vhw86W8_fb5682H21LzmqZy7KgChf3QaQ6MG0Xbdmg478FoOqDQdTu0tQHe9kyzrsF-pIZ1gjd9pxEUuyJvTrlr8D83jEkuNmqcZ-XQb1Hm5XshmMjC9iTUwccYcJRrsEseXVKQO2o5yT-o5Y5a0lpmkNl4fe6wDQuav7Yz2yx4fxJg3vOXxSCjtuh05h1QJ2m8_X-Pd_9E6Nk6q9X8A58wTn4LLlOUVMZskPf7wfd7gwDoO9az36nQqsY</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Ruano, Rodrigo</creator><creator>Aubry, Marie-Cécile</creator><creator>Barthe, Bruno</creator><creator>Mitanchez, Delphine</creator><creator>Dumez, Yves</creator><creator>Benachi, Alexandra</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters</title><author>Ruano, Rodrigo ; Aubry, Marie-Cécile ; Barthe, Bruno ; Mitanchez, Delphine ; Dumez, Yves ; Benachi, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-f81a0ae9b8c4034da166b54490dc1be7c26b62d04693c385e9f1d3874598ce0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Congenital diaphragmatic hernia</topic><topic>Fetal lung</topic><topic>Fetal malformation</topic><topic>Hernia, Diaphragmatic - complications</topic><topic>Hernia, Diaphragmatic - diagnosis</topic><topic>Hernias, Diaphragmatic, Congenital</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - diagnosis</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Pediatrics</topic><topic>Predictors of mortality</topic><topic>Prospective Studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary Artery - diagnostic imaging</topic><topic>Pulmonary Artery - embryology</topic><topic>Pulmonary hypoplasia</topic><topic>Surgery</topic><topic>Ultrasonography, Prenatal</topic><topic>Weights and Measures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruano, Rodrigo</creatorcontrib><creatorcontrib>Aubry, Marie-Cécile</creatorcontrib><creatorcontrib>Barthe, Bruno</creatorcontrib><creatorcontrib>Mitanchez, Delphine</creatorcontrib><creatorcontrib>Dumez, Yves</creatorcontrib><creatorcontrib>Benachi, Alexandra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruano, Rodrigo</au><au>Aubry, Marie-Cécile</au><au>Barthe, Bruno</au><au>Mitanchez, Delphine</au><au>Dumez, Yves</au><au>Benachi, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>43</volume><issue>4</issue><spage>606</spage><epage>611</epage><pages>606-611</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><abstract>Abstract Objective The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). Study Design In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH. Results The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls ( P < .001) and in fetuses with CDH who died ( P < .050). However, there was no significant association between PA diameters and PAH ( P ≥ .050). Conclusions The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18405704</pmid><doi>10.1016/j.jpedsurg.2007.12.003</doi><tpages>6</tpages></addata></record> |
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| subjects | Congenital diaphragmatic hernia Fetal lung Fetal malformation Hernia, Diaphragmatic - complications Hernia, Diaphragmatic - diagnosis Hernias, Diaphragmatic, Congenital Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - etiology Pediatrics Predictors of mortality Prospective Studies Pulmonary arteries Pulmonary Artery - diagnostic imaging Pulmonary Artery - embryology Pulmonary hypoplasia Surgery Ultrasonography, Prenatal Weights and Measures |
| title | Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters |
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