Homologue of the Aspergillus velvet Gene Regulates both Cephalosporin C Biosynthesis and Hyphal Fragmentation in Acremonium chrysogenum

The Aspergillus nidulans velvet (veA) gene encodes a global regulator of gene expression controlling sexual development as well as secondary metabolism. We have identified the veA homologue AcveA from Acremonium chrysogenum, the major producer of the β-lactam antibiotic cephalosporin C. Two differen...

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Veröffentlicht in:	Applied and Environmental Microbiology 2007-05, Vol.73 (10), p.3412-3422
Hauptverfasser:	Dreyer, Jacqueline, Eichhorn, Heiko, Friedlin, Ernst, Kürnsteiner, Hubert, Kück, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Acremonium - cytology Acremonium - genetics Acremonium - physiology Acremonium chrysogenum Aspergillus Aspergillus nidulans Aspergillus nidulans - genetics Bacteria Bacteriology Biological and medical sciences Blotting, Northern Cephalosporins - biosynthesis DNA, Fungal - chemistry DNA, Fungal - genetics Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression Gene Expression Regulation, Fungal Genes Genes, Regulator Genetic Complementation Test Hyphae - physiology Microbiology Molecular Sequence Data Morphogenesis Mycology Oxygenases - biosynthesis Reverse Transcriptase Polymerase Chain Reaction RNA, Bacterial - biosynthesis RNA, Bacterial - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Sequence Analysis, DNA Spores, Fungal
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