Loss of interferon-γ inducibility of the MHC class II antigen processing pathway in head and neck cancer: evidence for post-transcriptional as well as epigenetic regulation

Summary Background Abnormalities of the major histocompatibility complex (MHC) antigens by tumour cells impair the cellular immune response and promote tumour evasion from immune surveillance. So far, studies analysing the MHC class II expression levels in head and neck cancer have been limited. Ob...

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Veröffentlicht in:	British journal of dermatology (1951) 2008-05, Vol.158 (5), p.930-940
Hauptverfasser:	Meissner, M., Whiteside, T.L., Van Kuik-Romein, P., Valesky, E.M., Van Den Elsen, P.J., Kaufmann, R., Seliger, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigen Presentation - immunology antigen processing Biological and medical sciences Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - metabolism CD4-Positive T-Lymphocytes - immunology Cell Line, Tumor Dermatology DNA methylation Female Flow Cytometry head and neck cancer Head and Neck Neoplasms - immunology Head and Neck Neoplasms - metabolism Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Humans IFN-γ Immunohistochemistry Interferon-gamma - pharmacology Male Medical sciences MHC class II Middle Aged Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Reverse Transcriptase Polymerase Chain Reaction RNA Processing, Post-Transcriptional Transcription, Genetic Tumors
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