The Role of Disulfide Bonds and α-Helical Coiled-coils in the Biosynthesis of Type XIII Collagen and Other Collagenous Transmembrane Proteins

Type XIII collagen is a type II transmembrane protein with three collagenous (COL1–3) and four noncollagenous domains (NC1–4). The human α1(XIII) chain contains altogether eight cysteine residues. We introduced point mutations to six of the most N-terminal cysteine residues, and we show here that th...

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