Does Endothelin Play a Role in Chemoreception During Acute Hypoxia in Normal Men?

The peripheral chemoreceptors are the dominant reflex mechanism responsible for the rise in ventilation and muscle sympathetic nerve activity (MSNA) in response to hypoxia. Animal studies have suggested that endothelin (ET) plays an important role in chemosensitivity. Moreover, several human clinica...

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Veröffentlicht in:	Chest 2007-05, Vol.131 (5), p.1467-1472
Hauptverfasser:	Gujic, Marko, Houssière, Anne, Xhaët, Olivier, Argacha, Jean-François, Denewet, Nathalie, Noseda, André, Jespers, Pascale, Melot, Christian, Naeije, Robert, van de Borne, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Apnea - physiopathology Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Chemoreceptor Cells - physiology Cross-Over Studies Double-Blind Method endothelin Endothelin Receptor Antagonists Endothelins - physiology Heart Rate - drug effects Heart Rate - physiology human chemoreceptor Humans hypoxia Hypoxia - physiopathology Male Medical sciences Muscles - innervation Pneumology Pulmonary Ventilation - drug effects Pulmonary Ventilation - physiology Receptors, Endothelin - physiology Sulfonamides - pharmacology sympathetic nervous system Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology
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