Synthesis and GABA A receptor activity of oxygen-bridged neurosteroid analogs

Three analogs of neuroactive steroids were prepared ( 4– 6) in which 1,11- or 11,19-oxygen bridges give a constrained conformation. Their 3D structures were obtained by ab initio calculations and in the case of 3α-hydroxy-11,19-epoxypregn-4-ene-20-one ( 4), confirmed by X-ray analysis. Biological ac...

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