Design of potent PPARalpha agonists

Computational analysis of the ligand binding pocket of the three PPAR receptor subtypes was utilized in the design of potent PPARalpha agonists. Optimum PPARalpha potency and selectivity were obtained with substituents having van der Waals volume around 260. Compound 6 had a PPARalpha potency of 0.0...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-06, Vol.17 (11), p.3198-3202
Hauptverfasser:	Sauerberg, Per, Mogensen, John P, Jeppesen, Lone, Bury, Paul S, Fleckner, Jan, Olsen, Grith S, Jeppesen, Claus B, Wulff, Erik M, Pihera, Pavel, Havranek, Miroslav, Polivka, Zdenek, Pettersson, Ingrid
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Computers Crystallography Drug Design Ligands Phenylpropionates - chemical synthesis Phenylpropionates - chemistry Phenylpropionates - pharmacology PPAR alpha - agonists PPAR alpha - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!