Islet autoimmunity status in Asians with young-onset diabetes (12–40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors
Abstract In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singa...
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| Veröffentlicht in: | Diabetes research and clinical practice 2008-05, Vol.80 (2), p.224-230 |
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| container_title | Diabetes research and clinical practice |
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| creator | Thai, A.C Mohan, V Khalid, B.A.K Cockram, C.S Pan, C.Y Zimmet, P Yeo, J.P |
| description | Abstract In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12–40 years and diabetes duration |
| doi_str_mv | 10.1016/j.diabres.2007.12.003 |
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The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12–40 years and diabetes duration <12 months. Autoantibodies to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta cell function and cardio-metabolic risk parameters were assessed. Among our young patient cohort, 105 (11.5%) patients were GADA and/or IA-2A positives (Ab +ve). Ab +ve patients were younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to Ab −ve patients (54%). However, a substantial proportion of patients in both groups of patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet autoimmunity. At least 60% of Ab +ve and 50% of Ab −ve patients demonstrated classical features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, the cardio-metabolic risk factors, in particular atherogenic dyslipidaemia, hypertension and albuminuria were common in our patients with young-onset diabetes.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2007.12.003</identifier><identifier>PMID: 18207602</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Age of Onset ; Asian Continental Ancestry Group - ethnology ; Australia ; Autoimmunity ; Beta cell function ; Child ; Diabetes Mellitus, Type 2 - immunology ; Endocrinology & Metabolism ; Female ; GADA ; Glutamate Decarboxylase - immunology ; Humans ; IA-2A ; Islets of Langerhans - enzymology ; Islets of Langerhans - immunology ; Male ; Metabolic syndrome ; Protein Tyrosine Phosphatases - immunology ; Risk Factors ; Young Asians</subject><ispartof>Diabetes research and clinical practice, 2008-05, Vol.80 (2), p.224-230</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-858c7d877caa71cd487a0a727a4444ebfeca74c4138c7e105c9213f6199218b23</citedby><cites>FETCH-LOGICAL-c418t-858c7d877caa71cd487a0a727a4444ebfeca74c4138c7e105c9213f6199218b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2007.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18207602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thai, A.C</creatorcontrib><creatorcontrib>Mohan, V</creatorcontrib><creatorcontrib>Khalid, B.A.K</creatorcontrib><creatorcontrib>Cockram, C.S</creatorcontrib><creatorcontrib>Pan, C.Y</creatorcontrib><creatorcontrib>Zimmet, P</creatorcontrib><creatorcontrib>Yeo, J.P</creatorcontrib><creatorcontrib>the ASDIAB Study Group</creatorcontrib><creatorcontrib>ASDIAB Study Group</creatorcontrib><title>Islet autoimmunity status in Asians with young-onset diabetes (12–40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12–40 years and diabetes duration <12 months. Autoantibodies to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta cell function and cardio-metabolic risk parameters were assessed. Among our young patient cohort, 105 (11.5%) patients were GADA and/or IA-2A positives (Ab +ve). Ab +ve patients were younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to Ab −ve patients (54%). However, a substantial proportion of patients in both groups of patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet autoimmunity. At least 60% of Ab +ve and 50% of Ab −ve patients demonstrated classical features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, the cardio-metabolic risk factors, in particular atherogenic dyslipidaemia, hypertension and albuminuria were common in our patients with young-onset diabetes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Asian Continental Ancestry Group - ethnology</subject><subject>Australia</subject><subject>Autoimmunity</subject><subject>Beta cell function</subject><subject>Child</subject><subject>Diabetes Mellitus, Type 2 - immunology</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>GADA</subject><subject>Glutamate Decarboxylase - immunology</subject><subject>Humans</subject><subject>IA-2A</subject><subject>Islets of Langerhans - enzymology</subject><subject>Islets of Langerhans - immunology</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Protein Tyrosine Phosphatases - immunology</subject><subject>Risk Factors</subject><subject>Young Asians</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQhy0EokvhEUA-IZBIsJ1snOUAqir-VKrEAZC4WbPOhHqb2K3HAeXGO_AePBRPgtNdhMSFXCaSv2_GyW8YeyhFKYVsnu_KzsE2IpVKCF1KVQpR3WIr2WpVtErp22yVufbm_YjdI9oJIZqqXt9lR7JVQjdCrdjPMxowcZhScOM4eZdmTgnSRNx5fkIOPPFvLl3wOUz-SxE8ZXwZjQmJP5Hq1_cfteAzQqSnL7JBwTpILvi9ZgfnnYWB2wuIYBNGR8lZesZzB-AWh4H3k7c3BviOW4idC8WYT7dhcJZn4ZL3WQ2R7rM7PQyEDw71mH168_rj6bvi_P3bs9OT88LWsk1Fu26t7lqtLYCWtqtbDQK00lDnB7c9WtB1ZqvMoRRru1Gy6hu5ybXdquqYPd73vYrhekJKZnS03BU8homMFvWmUs0CrvegjYEoYm-uohshzkYKswRlduYQlFmCMlKZHFT2Hh0GTNsRu7_WIZkMvNoDmD_zq8NoyDr0FjsX0SbTBfffES__6fAni0uckXZhij7_QyMNZcF8WLZlWRah857I5nP1G1tGv9I</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Thai, A.C</creator><creator>Mohan, V</creator><creator>Khalid, B.A.K</creator><creator>Cockram, C.S</creator><creator>Pan, C.Y</creator><creator>Zimmet, P</creator><creator>Yeo, J.P</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Islet autoimmunity status in Asians with young-onset diabetes (12–40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors</title><author>Thai, A.C ; Mohan, V ; Khalid, B.A.K ; Cockram, C.S ; Pan, C.Y ; Zimmet, P ; Yeo, J.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-858c7d877caa71cd487a0a727a4444ebfeca74c4138c7e105c9213f6199218b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Asian Continental Ancestry Group - ethnology</topic><topic>Australia</topic><topic>Autoimmunity</topic><topic>Beta cell function</topic><topic>Child</topic><topic>Diabetes Mellitus, Type 2 - immunology</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>GADA</topic><topic>Glutamate Decarboxylase - immunology</topic><topic>Humans</topic><topic>IA-2A</topic><topic>Islets of Langerhans - enzymology</topic><topic>Islets of Langerhans - immunology</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Protein Tyrosine Phosphatases - immunology</topic><topic>Risk Factors</topic><topic>Young Asians</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thai, A.C</creatorcontrib><creatorcontrib>Mohan, V</creatorcontrib><creatorcontrib>Khalid, B.A.K</creatorcontrib><creatorcontrib>Cockram, C.S</creatorcontrib><creatorcontrib>Pan, C.Y</creatorcontrib><creatorcontrib>Zimmet, P</creatorcontrib><creatorcontrib>Yeo, J.P</creatorcontrib><creatorcontrib>the ASDIAB Study Group</creatorcontrib><creatorcontrib>ASDIAB Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thai, A.C</au><au>Mohan, V</au><au>Khalid, B.A.K</au><au>Cockram, C.S</au><au>Pan, C.Y</au><au>Zimmet, P</au><au>Yeo, J.P</au><aucorp>the ASDIAB Study Group</aucorp><aucorp>ASDIAB Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Islet autoimmunity status in Asians with young-onset diabetes (12–40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>80</volume><issue>2</issue><spage>224</spage><epage>230</epage><pages>224-230</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12–40 years and diabetes duration <12 months. Autoantibodies to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta cell function and cardio-metabolic risk parameters were assessed. Among our young patient cohort, 105 (11.5%) patients were GADA and/or IA-2A positives (Ab +ve). Ab +ve patients were younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to Ab −ve patients (54%). However, a substantial proportion of patients in both groups of patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet autoimmunity. At least 60% of Ab +ve and 50% of Ab −ve patients demonstrated classical features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, the cardio-metabolic risk factors, in particular atherogenic dyslipidaemia, hypertension and albuminuria were common in our patients with young-onset diabetes.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>18207602</pmid><doi>10.1016/j.diabres.2007.12.003</doi><tpages>7</tpages></addata></record> |
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| ispartof | Diabetes research and clinical practice, 2008-05, Vol.80 (2), p.224-230 |
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| subjects | Adolescent Adult Age of Onset Asian Continental Ancestry Group - ethnology Australia Autoimmunity Beta cell function Child Diabetes Mellitus, Type 2 - immunology Endocrinology & Metabolism Female GADA Glutamate Decarboxylase - immunology Humans IA-2A Islets of Langerhans - enzymology Islets of Langerhans - immunology Male Metabolic syndrome Protein Tyrosine Phosphatases - immunology Risk Factors Young Asians |
| title | Islet autoimmunity status in Asians with young-onset diabetes (12–40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors |
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