Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein–protein interaction with tumor suppressor p53

Pathways adopted by developing cancer cells for evasion of cellular surveillance mechanism deserve attention for therapeutic exploitation as well as for better prognosis. A novel mitotic kinase, PDZ-binding kinase or PBK, which is upregulated in a variety of neoplasms including hematological maligna...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-06, Vol.358 (1), p.181-188
Hauptverfasser:	Nandi, Asit K., Ford, Tamara, Fleksher, Daniel, Neuman, Brian, Rapoport, Aaron P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Cell Cycle Cell Cycle Proteins - metabolism Cell Line, Tumor DNA Damage DNA damage checkpoint Down-Regulation Doxorubicin - pharmacology Humans Mitogen-Activated Protein Kinase Kinases Mitotic kinase Mutation PDZ-binding kinase Protein Binding Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Protein–protein interaction Tumor suppressor p53 Tumor Suppressor Protein p53 - metabolism
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