Combination of a SAW-biosensor with MALDI mass spectrometric analysis

A S-sens® K5 surface acoustic wave biosensor was coupled with mass spectrometry (SAW-MS) for the analysis of a protein complex consisting of human blood clotting cascade factor α-thrombin and human antithrombin III, a specific blood plasma inhibitor of thrombin. Specific binding of antithrombin III...

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Veröffentlicht in:	Biosensors & bioelectronics 2008-05, Vol.23 (10), p.1496-1502
Hauptverfasser:	Treitz, G., Gronewold, T.M.A., Quandt, E., Zabe-Kühn, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustics - instrumentation Antithrombin III - analysis Antithrombin III - chemistry Aptamer Biological and medical sciences Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensors Biotechnology Blood Chemical Analysis - instrumentation Blood Chemical Analysis - methods Blood Proteins - analysis Complex Mixtures - analysis Complex Mixtures - chemistry Equipment Design Equipment Failure Analysis Fundamental and applied biological sciences. Psychology Humans MALDI-ToF MS Methods. Procedures. Technologies Peptide Hydrolases - analysis Peptide Hydrolases - chemistry Protein-complexes Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Surface acoustic wave sensor Thrombin Various methods and equipments
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