A novel approach for analysis of oligonucleotide-cisplatin interactions by continuous elution gel electrophoresis coupled to isotope dilution inductively coupled plasma mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry

In this work we present a novel approach for in vitro studies of cisplatin interactions with 8‐mer oligonucleotides. The approach is based on the recently developed coupling of continuous elution gel electrophoresis (GE) to an inductively coupled plasma‐sector field mass spectrometer (ICP‐SFMS) with...

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Veröffentlicht in:	Electrophoresis 2008-04, Vol.29 (7), p.1451-1459
Hauptverfasser:	Brüchert, Wolfram, Krüger, Ralf, Tholey, Andreas, Montes-Bayón, María, Bettmer, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Cisplatin Cisplatin - chemistry Electrophoresis - methods Gel electrophoresis Inductively coupled plasma mass spectrometry Isotope dilution analysis Kinetics Matrix-assisted laser desorption/ionization mass spectrometry Oligonucleotides Oligonucleotides - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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