The silver locus product (Silv/gp100/Pmel17) as a new tool for the analysis of melanosome transfer in human melanocyte-keratinocyte co-culture

: Melanosomes are melanocyte‐specific lysosome‐related organelles that are transferred to keratinocytes of the epidermis and anagen hair bulb. Transferred melanin forms supra‐nuclear caps that protect epidermal keratinocytes against UV irradiation. The mechanism(s) responsible for melanosome transf...

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Veröffentlicht in:	Experimental dermatology 2008-05, Vol.17 (5), p.418-426
Hauptverfasser:	Singh, Suman K., Nizard, Carine, Kurfurst, Robin, Bonte, Frederic, Schnebert, Sylvianne, Tobin, Desmond J.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology Analysis of Variance Antibodies, Monoclonal Biological and medical sciences Cells, Cultured Coculture Techniques Dermatology filopodia Fluorescent Antibody Technique gp100 gp100 Melanoma Antigen Humans keratinocyte Keratinocytes - drug effects Keratinocytes - physiology Keratins - analysis Medical sciences Melanins - analysis melanocyte Melanocytes - drug effects Melanocytes - physiology melanosome transfer Melanosomes - drug effects Melanosomes - metabolism Melanosomes - physiology Membrane Glycoproteins - analysis Membrane Glycoproteins - metabolism Microscopy - methods phagocytosis Phagocytosis - physiology Pmel17 Pseudopodia - physiology Trypsin Inhibitors - pharmacology
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