A noise model for mass spectrometry based proteomics

Motivation: Mass spectrometry data are subjected to considerable noise. Good noise models are required for proper detection and quantification of peptides. We have characterized noise in both quadrupole time-of-flight (Q-TOF) and ion trap data, and have constructed models for the noise. Results: We...

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Veröffentlicht in:	Bioinformatics 2008-04, Vol.24 (8), p.1070-1077
Hauptverfasser:	Du, Peicheng, Stolovitzky, Gustavo, Horvatovich, Peter, Bischoff, Rainer, Lim, Jihyeon, Suits, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Computer Simulation Fundamental and applied biological sciences. Psychology General aspects Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Models, Chemical Models, Statistical Proteins - analysis Proteins - chemistry Proteomics - methods Reproducibility of Results Sensitivity and Specificity Sequence Analysis, Protein - methods Spectrometry, Mass, Electrospray Ionization - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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