Metabolism in rats of NC100692, an RGD-peptide for imaging of angiogenesis

The 99mTc complex of NC100692 is being evaluated as a diagnostic agent for imaging of angiogenesis. We here report in vivo studies performed with NC100692 and 14C-labelled NC100692 using liquid chromatography coupled to either an ion-trap mass spectrometer or a radiochemical detector. Following inje...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2008-05, Vol.47 (1), p.164-169
Hauptverfasser:	Roed, L., Oulie, I., Knüttel, T., Toft, K.G., Hustvedt, S.O., Skotland, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Angiogenesis Animals Autoradiography Biological and medical sciences Carbon Radioisotopes Fundamental and applied biological sciences. Psychology General pharmacology LC–MS Male Medical sciences Metabolism NC100692 Neovascularization, Pathologic - diagnosis Oligopeptides - metabolism Peptides, Cyclic - metabolism Pharmacology. Drug treatments Rat Rats Rats, Sprague-Dawley
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